دورية أكاديمية
Longitudinal Analysis of Neutralizing Potency against SARS-CoV-2 in the Recovered Patients after Treatment with or without Favipiravir
| العنوان: | Longitudinal Analysis of Neutralizing Potency against SARS-CoV-2 in the Recovered Patients after Treatment with or without Favipiravir |
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| المؤلفون: | Kanako Shinada, Takashi Sato, Saya Moriyama, Yu Adachi, Masahiro Shinoda, Shinichiro Ota, Miwa Morikawa, Masamichi Mineshita, Takayuki Matsumura, Yoshimasa Takahashi, Masaharu Shinkai |
| المصدر: | Viruses, Vol 14, Iss 670, p 670 (2022) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | favipiravir, COVID-19, SARS-CoV-2, neutralizing antibody, neutralizing potency index, neutralization breadth index, Microbiology, QR1-502 |
| الوصف: | The effect of treatment with favipiravir, an antiviral purine nucleoside analog, for coronavirus disease 2019 (COVID-19) on the production and duration of neutralizing antibodies for SARS-CoV-2 was explored. There were 17 age-, gender-, and body mass index-matched pairs of favipiravir treated versus control selected from a total of 99 patients recovered from moderate COVID-19. These subjects participated in the longitudinal (>6 months) analysis of (i) SARS-CoV-2 spike protein’s receptor-binding domain IgG, (ii) virus neutralization assay using authentic virus, and (iii) neutralization potency against original (WT) SARS-CoV-2 and cross-neutralization against B.1.351 (beta) variant carrying triple mutations of K417N, E484K, and N501Y. The results demonstrate that the use of favipiravir: (1) significantly accelerated the elimination of SARS-CoV-2 in the case vs. control groups ( p = 0.027), (2) preserved the generation and persistence of neutralizing antibodies in the host, and (3) did not interfere the maturation of neutralizing potency of anti-SARS-CoV-2 and neutralizing breadth against SARS-CoV-2 variants. In conclusion, treatment of COVID-19 with favipiravir accelerates viral clearance and does not interfere the generation or maturation of neutralizing potency against both WT SARS-CoV-2 and its variants. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1999-4915 |
| العلاقة: | https://www.mdpi.com/1999-4915/14/4/670Test; https://doaj.org/toc/1999-4915Test; https://doaj.org/article/d8a4a05eefcf44759a2fcd3a846f8c62Test |
| DOI: | 10.3390/v14040670 |
| الإتاحة: | https://doi.org/10.3390/v14040670Test https://doaj.org/article/d8a4a05eefcf44759a2fcd3a846f8c62Test |
| رقم الانضمام: | edsbas.4FAF0D08 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19994915 |
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| DOI: | 10.3390/v14040670 |