دورية أكاديمية
Cardiac conduction system anomalies and sudden cardiac death: insights from murine models
| العنوان: | Cardiac conduction system anomalies and sudden cardiac death: insights from murine models |
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| المؤلفون: | Amelia Eva Aranega, Angel Jose de la Rosa, Diego eFranco |
| المصدر: | Frontiers in Physiology, Vol 3 (2012) |
| بيانات النشر: | Frontiers Media S.A. |
| سنة النشر: | 2012 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | ion channel, sudden death, Cardiac conduction system, Physiology, QP1-981 |
| الوصف: | The cardiac conduction system (CCS) is a series of specialized tissues in the heart responsible for the initiation and co-ordination of the heartbeat. Alterations in the CCS, especially the His-Purkinje system, have been identified as an important player in the generation of lethal arrhythmias. Unstable arrhythmias secondary to channelopathies highly increase the risk of sudden cardiac death (SCD). Sudden cardiac death is a major contributor to mortality in industrialized nations, and most cases of SCD in the young are related to inherited ion channel diseases. In this review we examine how murine transgenic models have contributed to understanding that a broad variety of cardiac arrhythmias involve the cardiac specialized conduction system and may lead to sudden cardiac death. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1664-042X |
| العلاقة: | http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00211/fullTest; https://doaj.org/toc/1664-042XTest; https://doaj.org/article/66497ad06f814e40be6d3471fb7990a2Test |
| DOI: | 10.3389/fphys.2012.00211 |
| الإتاحة: | https://doi.org/10.3389/fphys.2012.00211Test https://doaj.org/article/66497ad06f814e40be6d3471fb7990a2Test |
| رقم الانضمام: | edsbas.B2D64DB |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 1664042X |
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| DOI: | 10.3389/fphys.2012.00211 |