دورية أكاديمية
Targeting Mitochondria in Diabetes
| العنوان: | Targeting Mitochondria in Diabetes |
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| المؤلفون: | Nina Krako Jakovljevic, Kasja Pavlovic, Aleksandra Jotic, Katarina Lalic, Milica Stoiljkovic, Ljiljana Lukic, Tanja Milicic, Marija Macesic, Jelena Stanarcic Gajovic, Nebojsa M. Lalic |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 6642, p 6642 (2021) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | type 2 diabetes, insulin resistance, mitochondria, respiration, respiratory capacity, liver, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Type 2 diabetes (T2D), one of the most prevalent noncommunicable diseases, is often preceded by insulin resistance (IR), which underlies the inability of tissues to respond to insulin and leads to disturbed metabolic homeostasis. Mitochondria, as a central player in the cellular energy metabolism, are involved in the mechanisms of IR and T2D. Mitochondrial function is affected by insulin resistance in different tissues, among which skeletal muscle and liver have the highest impact on whole-body glucose homeostasis. This review focuses on human studies that assess mitochondrial function in liver, muscle and blood cells in the context of T2D. Furthermore, different interventions targeting mitochondria in IR and T2D are listed, with a selection of studies using respirometry as a measure of mitochondrial function, for better data comparison. Altogether, mitochondrial respiratory capacity appears to be a metabolic indicator since it decreases as the disease progresses but increases after lifestyle (exercise) and pharmacological interventions, together with the improvement in metabolic health. Finally, novel therapeutics developed to target mitochondria have potential for a more integrative therapeutic approach, treating both causative and secondary defects of diabetes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/22/12/6642Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test; https://doaj.org/article/2578bbd4fa3e4c3fbaceceafda71ea9fTest |
| DOI: | 10.3390/ijms22126642 |
| الإتاحة: | https://doi.org/10.3390/ijms22126642Test https://doaj.org/article/2578bbd4fa3e4c3fbaceceafda71ea9fTest |
| رقم الانضمام: | edsbas.8616BF0A |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms22126642 |