دورية أكاديمية
Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepines
| العنوان: | Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepines |
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| المؤلفون: | Cruz-Lopez, Olga, Ner, Matilde, Nerin-Fonz, Francho, Jimenez-Martinez, Yaiza, Araripe, David, Marchal, Juan A., Boulaiz, Houria, Gutiérrez-de-Terán, Hugo, Campos, Joaquin M., Conejo-Garcia, Ana |
| بيانات النشر: | Uppsala universitet, Institutionen för cell- och molekylärbiologi Uppsala universitet, Beräkningsbiologi och bioinformatik Univ Granada, Fac Pharm, Dept Med & Organ Chem, Campus Cartuja S-N, Granada 18071, Spain.;Univ Granada, Biosanit Inst Granada Ibs GRANADA, SAS, Granada, Spain. Univ Granada, Fac Pharm, Dept Med & Organ Chem, Campus Cartuja S-N, Granada 18071, Spain. Univ Granada, Biosanit Inst Granada Ibs GRANADA, SAS, Granada, Spain.;Univ Granada, Biopathol & Med Regenerat Inst, Granada, Spain.;Univ Granada, Dept Human Anat & Embryol, Excellence Res Unit Modeling Nat MNat, Granada, Spain. TAYLOR & FRANCIS LTD |
| سنة النشر: | 2021 |
| المجموعة: | Uppsala University: Publications (DiVA) |
| مصطلحات موضوعية: | Antitumour, pyroptosis, HER2 receptor, molecular modelling, benzoxazepines, Medicinal Chemistry, Läkemedelskemi, Biochemistry and Molecular Biology, Biokemi och molekylärbiologi |
| الوصف: | A series of 11 new substituted 1,5-dihydro-4,1-benzoxazepine derivatives was synthesised to study the influence of the methyl group in the 1-(benzenesulphonyl) moiety, the replacement of the purine by the benzotriazole bioisosteric analogue, and the introduction of a bulky substituent at position 6 of the purine, on the biological effects. Their inhibition against isolated HER2 was studied and the structure-activity relationships have been confirmed by molecular modelling studies. The most potent compound against isolated HER2 is 9a with an IC50 of 7.31 mu M. We have investigated the effects of the target compounds on cell proliferation. The most active compound (7c) against all the tumour cell lines studied (IC50 0.42-0.86 mu M) does not produce any modification in the expression of pro-caspase 3, but increases the caspase 1 expression, and promotes pyroptosis. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Journal of enzyme inhibition and medicinal chemistry (Print), 1475-6366, 2021, 36:1, s. 1553-1563; orcid:0000-0002-5548-7608; orcid:0000-0003-0459-3491; orcid:0000-0002-9035-8123; http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-453573Test; PMID 34251942; ISI:000672940800001 |
| DOI: | 10.1080/14756366.2021.1948841 |
| الإتاحة: | https://doi.org/10.1080/14756366.2021.1948841Test http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-453573Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.D1B90C9D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1080/14756366.2021.1948841 |
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