المؤلفون: George Bakris, Albert T. Profy, Jennifer G. Chickering, Jelena P. Seferovic, John P. Hanrahan, Ian H. de Boer, Michael D. Cressman, Mark G. Currie, James Wakefield, G. Todd Milne, Kenneth E. Carlson, Phebe J. Wilson, Yueh-Tyng Chien

المصدر: Clin J Am Soc Nephrol

مصطلحات موضوعية: Diarrhea, Male, medicine.medical_specialty, Epidemiology, Blood Pressure, Type 2 diabetes, Urine, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, Placebo, Dizziness, Gastroenterology, Syncope, Placebos, Diabetic nephropathy, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Heart Rate, Diabetes mellitus, Internal medicine, medicine, Albuminuria, Humans, Diabetic Nephropathies, Adverse effect, Aged, 030304 developmental biology, Glycated Hemoglobin, 0303 health sciences, Transplantation, business.industry, Guanylyl Cyclase C Agonists, Original Articles, Middle Aged, medicine.disease, Clinical trial, Pyrimidines, Diabetes Mellitus, Type 2, Nephrology, Creatinine, Pyrazoles, Female, medicine.symptom, business, Constipation, Glomerular Filtration Rate

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5a08796e56d4397df9ed0dd1e1a556Test
https://doi.org/10.2215/cjn.08410520Test

المؤلفون: Jenny Tobin, Albert T. Profy, Ali R. Banijamali, Mark G. Currie, James Wakefield, Jaime L. Masferrer, G. Todd Milne, Daniel P. Zimmer, Andrew Carvalho, Peter Germano, Barden Timothy Claude

المصدر: Pharmacology Research & Perspectives
Pharmacology Research & Perspectives, Vol 8, Iss 2, Pp n/a-n/a (2020)

مصطلحات موضوعية: Male, medicine.medical_specialty, sGC, Metabolite, praliciguat, Glucuronidation, Adipose tissue, RM1-950, 030226 pharmacology & pharmacy, Excretion, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Feces, 0302 clinical medicine, Soluble Guanylyl Cyclase, Pharmacokinetics, Oral administration, nitric oxide, Internal medicine, QWBA, medicine, Animals, Bile, Rats, Long-Evans, Tissue Distribution, General Pharmacology, Toxicology and Pharmaceutics, Original Articles, Bioavailability, cGMP, Endocrinology, Pyrimidines, Neurology, chemistry, 030220 oncology & carcinogenesis, Pyrazoles, Original Article, excretion, Therapeutics. Pharmacology, absorption, metabolism, pharmacokinetics, Drug metabolism, mass balance

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b3e4df24159164c127118e8e21c0b4Test
http://europepmc.org/articles/PMC7171252Test

المؤلفون: Linda Morrow, Daniel P. Zimmer, Jennifer G. Chickering, Jelena P. Seferovic, Andrew L. Frelinger, Kenneth E. Carlson, Phebe J. Wilson, Mark G. Currie, G. Todd Milne, James Wakefield, Joon Jung, Albert T. Profy, John P. Hanrahan, Michael Hall, Alan D. Michelson

المصدر: Diabetologia

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, medicine.medical_specialty, Mean arterial pressure, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, Placebo, Soluble guanylate cyclase stimulator, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Insulin resistance, BP, Double-Blind Method, Internal medicine, Internal Medicine, Medicine, Humans, Hypoglycemic Agents, Insulin, Diabetic Nephropathies, Cyclic guanosine monophosphate, Adverse effect, Aged, business.industry, Guanylyl Cyclase C Agonists, Endothelial function, Middle Aged, medicine.disease, 030104 developmental biology, Pyrimidines, Treatment Outcome, chemistry, Tolerability, Diabetes Mellitus, Type 2, Hyperlipidaemia, Pharmacodynamics, Hypertension, Pyrazoles, Drug Therapy, Combination, Female, business, Asymmetric dimethylarginine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b4281f0807fbb3e5d7d441113ef655Test
https://pubmed.ncbi.nlm.nih.gov/31858186Test

المؤلفون: Albert T. Profy, G. Todd Milne, Marina Mihova, Michael Hall, Dennis Ruff, James Wakefield, Phebe J. Wilson, Mark G. Currie, Jennifer G. Chickering, John P. Hanrahan

المصدر: Clinical pharmacology in drug development. 8(5)

مصطلحات موضوعية: Adult, Male, Pharmaceutical Science, Vasodilation, Pharmacology, Placebo, 030226 pharmacology & pharmacy, Nitric oxide, 03 medical and health sciences, chemistry.chemical_compound, Young Adult, 0302 clinical medicine, Soluble Guanylyl Cyclase, Pharmacokinetics, Double-Blind Method, Medicine, Humans, Pharmacology (medical), Adverse effect, Cyclic GMP, Cross-Over Studies, business.industry, Middle Aged, Healthy Volunteers, Blood pressure, Pyrimidines, chemistry, Tolerability, 030220 oncology & carcinogenesis, Pharmacodynamics, Pyrazoles, Female, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250b35c417ffa1a1a47e3581662896d2Test
https://pubmed.ncbi.nlm.nih.gov/30422390Test

المؤلفون: Sylvie G. Bernier, G. Todd Milne, Joel D. Moore, Daniel P. Zimmer, Renee Sarno, Sheila Ranganath, Kim Tang, Albert T. Profy, Jaime L. Masferrer, G-Yoon Jamie Im, Guang Liu, James E. Sheppeck, Courtney Shea, Ali R. Banijamali, Sarah Jacobson, James Wakefield, Jenny Tobin, Peter Germano, Kim Long, Kristine Sykes, Mark G. Currie, Joy Miyashiro

المصدر: The Journal of pharmacology and experimental therapeutics. 365(3)

مصطلحات موضوعية: 0301 basic medicine, Male, Endothelium, medicine.medical_treatment, Anti-Inflammatory Agents, Inflammation, Blood Pressure, 030204 cardiovascular system & hematology, Pharmacology, Kidney, Nitric Oxide, Nitric oxide, Diabetic nephropathy, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Soluble Guanylyl Cyclase, Fibrosis, medicine, Renal fibrosis, Animals, Humans, Tissue Distribution, Endothelial dysfunction, Antihypertensive Agents, Arteries, medicine.disease, Rats, Vasodilation, Disease Models, Animal, Proteinuria, 030104 developmental biology, medicine.anatomical_structure, Cytokine, HEK293 Cells, Pyrimidines, chemistry, Molecular Medicine, Pyrazoles, Endothelium, Vascular, medicine.symptom, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c4901b890abc311faa878fa692a045Test
https://pubmed.ncbi.nlm.nih.gov/29643251Test