دورية أكاديمية
Urinary F2-isoprostanes, a biomarker of lipid peroxidation, independently correlate with survival in a multicenter prospective cohort of incident pulmonary arterial hypertension
| العنوان: | Urinary F2-isoprostanes, a biomarker of lipid peroxidation, independently correlate with survival in a multicenter prospective cohort of incident pulmonary arterial hypertension |
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| المؤلفون: | Jean Luc Cracowski, Bruno Degano, François Chabot, José Labarere, Edzard Schwedhelm, Denis Monneret, Christophe Pison, Ari Chaouat, Martine Reynaud Gaubert, Patrice Faure, Renke Maas, Jean Charles Renversez, Claire Cracowski, Olivier Sitbon, Gerald Simmoneau, Azzedine Yaici, Marc Humbert, IULIANO, Luigi |
| المساهمون: | Jean Luc, Cracowski, Bruno, Degano, François, Chabot, José, Labarere, Edzard, Schwedhelm, Denis, Monneret, Iuliano, Luigi, Christophe, Pison, Ari, Chaouat, Martine Reynaud, Gaubert, Patrice, Faure, Renke, Maa, Jean Charles, Renversez, Claire, Cracowski, Olivier, Sitbon, Gerald, Simmoneau, Azzedine, Yaici, Marc, Humbert |
| بيانات النشر: | Northbrook, IL 60062:(800)343-2227, (847)498-1400 |
| سنة النشر: | 2012 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | pulmonary hypertension, isoprostane, oxysterols |
| الوصف: | Rationale:Within the last decade biochemical markers have emerged as attractive tools to assess pulmonary arterial hypertension prognosis, being non-invasive and easily repeatable.ObjectivesTo determine whether biomarkers measured at initial diagnostic right heart catheterization predict 3-year all-cause mortality for incident cases of pulmonary arterial hypertension, independently of clinical and hemodynamic parameters.MethodsIncident cases of pulmonary arterial hypertension were enrolled between December 2003 and April 2006 in 6 centers from the French Network on Pulmonary Hypertension and followed during 3 years. Venous blood samples were taken during right heart catheterization and analyses were centralized.ResultsAmong 110 enrolled patients, 11 underwent lung or heart/lung transplantation and 27 died during follow-up. The Kaplan-Meier estimates of survival were 91%, 78% and 75% at 1, 2, and 3 years, respectively. Plasma big endothelin-1 (hazard ratio [HR] per 1 standard deviation [SD] increase, 1.48, 95% confidence interval [CI], 1.14 to 1.92), serum troponin T >0.01 mg/L (HR, 2.35, 95%CI, 1.05 to 5.29) and urinary F(2)-isoprostanes (15-F(2t)-isoprostane) (HR per 1 SD increase, 1.76, 95%CI, 1.31 to 2.36) were associated with increased unadjusted hazard of death. In multivariate analysis adjusting for patients' characteristics, urinary F(2)-isoprostanes were the only biomarker that remained independently associated with increased hazard of death (HR, 1.82 per 1 SD increase, 95%CI, 1.28 to 2.60).ConclusionThis study shows that urinary F(2)-isoprostane levels, biomarkers of lipid peroxidation, quantified at initial diagnostic right heart catheterization are independently associated with mortality in a cohort of patients with incident pulmonary arterial hypertension. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/22406961; info:eu-repo/semantics/altIdentifier/wos/WOS:000317153200011; volume:142; firstpage:869; lastpage:876; numberofpages:8; journal:CHEST; http://hdl.handle.net/11573/432836Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84865488316; http://www.chestnet.orgTest |
| DOI: | 10.1378/chest.11-1267 |
| الإتاحة: | https://doi.org/10.1378/chest.11-1267Test http://hdl.handle.net/11573/432836Test http://www.chestnet.orgTest |
| رقم الانضمام: | edsbas.256F730C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1378/chest.11-1267 |
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