دورية أكاديمية
The effects of acute social stress on epidermal Langerhans' cell frequency and expression of cutaneous neuropeptides
| العنوان: | The effects of acute social stress on epidermal Langerhans' cell frequency and expression of cutaneous neuropeptides |
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| المؤلفون: | C. E. Kleyn, R. Saraceno, H. L. Richards, D. G. Fortune, M. Cumberbatch, R. J. Dearman, G. Terenghi, I. Kimber, C. E. M. Griffiths, L. Schneider, C. Mantovani |
| المساهمون: | C.E. Kleyn, L. Schneider, R. Saraceno, C. Mantovani, H.L. Richard, D.G. Fortune, M. Cumberbatch, R.J. Dearman, G. Terenghi, I. Kimber, C.E.M. Griffiths |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2008 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Acute Disease, Adolescent, Adult, Calcitonin Gene-Related Peptide, Cell Movement, Epidermis, Female, Humans, Langerhans Cells, Male, Middle Aged, Nerve Endings, Neuropeptides, Pain Measurement, Stress, Psychological, Ubiquitin Thiolesterase, Settore MED/13 - Endocrinologia |
| الوصف: | Psychological stress is believed to exacerbate inflammatory skin disease but the underlying mechanisms are poorly understood. We investigated the impact of acute social stress - Trier public speaking test - on: epidermal Langerhans' cell (LC) frequency; and cutaneous nerve fiber expression of protein gene product (PGP) 9.5 and calcitonin gene-related peptide (CGRP). Thirty-six healthy volunteers each had a pair of baseline 6 mm biopsies taken from sun-protected buttock skin. A second pair of biopsies was taken from contralateral buttock 4 hours (n=5) or 24 hours (n=15) after the Trier stressor. Controls (n=16) did not perform the Trier and had biopsies 24 hours apart. One of each pair of biopsies (baseline; 4 or 24 hours) was processed for counts of epidermal CD1a + LC; the other examined for PGP 9.5 and CGRP expression. We observed a significant (P<0.01) 16.4% reduction in epidermal LC frequency 24 hours post-stressor as compared with baseline; there was no significant change from baseline in non-stressed controls. At 24 hours, PGP 9.5 and CGRP were increased (P=0.025) and reduced (P=0.03), respectively, from baseline in the stressed group compared with controls. These data suggest that acute social stress reduces epidermal LC frequency and modulates cutaneous neuropeptide expression thereby supporting the concept of a "brain-skin" axis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/17989731; info:eu-repo/semantics/altIdentifier/wos/WOS:000255250400028; volume:128; issue:5; firstpage:1273; lastpage:1279; numberofpages:7; journal:JOURNAL OF INVESTIGATIVE DERMATOLOGY; http://hdl.handle.net/2434/232530Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-42149163393 |
| DOI: | 10.1038/sj.jid.5701144 |
| الإتاحة: | https://doi.org/10.1038/sj.jid.5701144Test http://hdl.handle.net/2434/232530Test |
| رقم الانضمام: | edsbas.98352704 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/sj.jid.5701144 |
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