المؤلفون: Simona, Schäfer, Elisa, Mallick, Louisa, Schwed, Alexandra, König, Jian, Zhao, Nicklas, Linz, Timothy Hadarsson, Bodin, Johan, Skoog, Nina, Possemis, Daphne, Ter Huurne, Anna, Zettergren, Silke, Kern, Simona, Sacuiu, Inez, Ramakers, Ingmar, Skoog, Johannes, Tröger

المساهمون: RS: MHeNs - R3 - Neuroscience, Basic Neuroscience 2, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Psychology 1, Psychology 2

المصدر: Journal of Alzheimer's Disease, 91(3), 1165-1171. IOS Press

مصطلحات موضوعية: Psychiatry and Mental health, Clinical Psychology, General Neuroscience, General Medicine, Geriatrics and Gerontology

الوصف: BACKGROUND: Modern prodromal Alzheimer's disease (AD) clinical trials might extend outreach to a general population, causing high screen-out rates and thereby increasing study time and costs. Thus, screening tools that cost-effectively detect mild cognitive impairment (MCI) at scale are needed.OBJECTIVE: Develop a screening algorithm that can differentiate between healthy and MCI participants in different clinically relevant populations.METHODS: Two screening algorithms based on the remote ki:e speech biomarker for cognition (ki:e SB-C) were designed on a Dutch memory clinic cohort (N = 121) and a Swedish birth cohort (N = 404). MCI classification was each evaluated on the training cohort as well as across on the unrelated validation cohort.RESULTS: The algorithms achieved a performance of AUC 0.73 and AUC 0.77 in the respective training cohorts and AUC 0.81 in the unseen validation cohort.CONCLUSION: The results indicate that a ki:e SB-C based algorithm robustly detects MCI across different cohorts and languages, which has the potential to make current trials more efficient and improve future primary health care.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309dee186fd0b3643ecb8375d6ea4d0fTest
https://doi.org/10.3233/jad-220762Test

المؤلفون: Daphne ter Huurne, Inez Ramakers, Nina Possemis, Leonie Banning, Angelique Gruters, Stephanie Van Asbroeck, Alexandra König, Nicklas Linz, Johannes Tröger, Kai Langel, Frans Verhey, Marjolein de Vugt

المصدر: Archives of Clinical Neuropsychology.

مصطلحات موضوعية: MILD COGNITIVE IMPAIRMENT, NORMATIVE DATA, EDUCATION, General Medicine, PERFORMANCE, ALZHEIMERS-DISEASE, Psychiatry and Mental health, Clinical Psychology, VERBAL FLUENCY, Neuropsychology and Physiological Psychology, AGE, Cognitive dysfunction, PARKINSONS-DISEASE, Neuropsychological tests, TESTS, Speech, PARTICIPANTS, Alzheimer disease

الوصف: Objective To investigate whether automatic analysis of the Semantic Verbal Fluency test (SVF) is reliable and can extract additional information that is of value for identifying neurocognitive disorders. In addition, the associations between the automatically derived speech and linguistic features and other cognitive domains were explored. Method We included 135 participants from the memory clinic of the Maastricht University Medical Center+ (with Subjective Cognitive Decline [SCD; N = 69] and Mild Cognitive Impairment [MCI]/dementia [N = 66]). The SVF task (one minute, category animals) was recorded and processed via a mobile application, and speech and linguistic features were automatically extracted. The diagnostic performance of the automatically derived features was investigated by training machine learning classifiers to differentiate SCD and MCI/dementia participants. Results The intraclass correlation for interrater reliability between the clinical total score (golden standard) and automatically derived total word count was 0.84. The full model including the total word count and the automatically derived speech and linguistic features had an Area Under the Curve (AUC) of 0.85 for differentiating between people with SCD and MCI/dementia. The model with total word count only and the model with total word count corrected for age showed an AUC of 0.75 and 0.81, respectively. Semantic switching correlated moderately with memory as well as executive functioning. Conclusion The one-minute SVF task with automatically derived speech and linguistic features was as reliable as the manual scoring and differentiated well between SCD and MCI/dementia. This can be considered as a valuable addition in the screening of neurocognitive disorders and in clinical practice.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449c9b2306b9d3201b0e91f334358209Test
https://doi.org/10.1093/arclin/acac105Test

المؤلفون: Céline Labbé, Alexandra König, Hali Lindsay, Nicklas Linz, Johannes Tröger, Philippe Robert

المصدر: Alzheimer's & Dementia. 18

مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::58be6d34fa42c506653dbb6c3fbeee93Test
https://doi.org/10.1002/alz.064486Test

المؤلفون: Johan Skoog, Elisa Mallick, Timothy Hadarsson Bodin, Mario Mina, Nicklas Linz, Johannes Tröger, Ingmar Skoog

المصدر: Alzheimer's & Dementia. 18

مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::9e50e4564a3b9190a4c6b5b8e57b2222Test
https://doi.org/10.1002/alz.067821Test

المؤلفون: Nicklas Linz, Elisa Mallick, Mario Mina, Nina Possemis, Alexandra König, Daphne B.G. ter Huurne, Inez H.G.B. Ramakers, Johannes Tröger

المصدر: Alzheimer's & Dementia. 18

مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d76b16caf1c911123fd79b740922f60eTest
https://doi.org/10.1002/alz.061600Test

المؤلفون: Alexandra König, Inez H.G.B. Ramakers, Nicklas Linz, Radia Zeghari, Philippe Robert

المصدر: Alzheimer's & Dementia. 17

مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::1975752bd73afb962c29c4472a5c74e1Test
https://doi.org/10.1002/alz.049766Test

المؤلفون: Alexandra König, Radia Zeghari, Rachid Guerchouche, Francois Bremond, Vincent Bultingaire, Philippe Robert, Nicklas Linz

المصدر: Alzheimer's & Dementia. 17

مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4423912e3805f30f80af1fa0144f8982Test
https://doi.org/10.1002/alz.050302Test

المؤلفون: Daphne BG ter Huurne, Inez HGB Ramakers, Nicklas Linz, Alexandra König, Kai Langel, Hali Lindsay, Frans RJ Verhey, Marjolein de Vugt

المصدر: Alzheimer's & Dementia. 17

مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b7c5029ff869831abb062a6ee32eb83bTest
https://doi.org/10.1002/alz.050380Test

المؤلفون: Jessica Peter, Nicklas Linz, Johannes Tröger, Hali Lindsay, Jutta Kray, Mario Magued Mina, Stefan Klöppel

مصطلحات موضوعية: medicine.medical_specialty, Neuropsychological Tests, Audiology, behavioral disciplines and activities, 050105 experimental psychology, Task (project management), Executive Function, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Semantic memory, Verbal fluency test, Cognitive Dysfunction, 0501 psychology and cognitive sciences, In patient, Latency (engineering), Control (linguistics), Set (psychology), Point (typography), General Neuroscience, 05 social sciences, Semantics, Psychiatry and Mental health, Clinical Psychology, 150 Psychologie, Neurology (clinical), Psychology, 610 Medizin und Gesundheit, 030217 neurology & neurosurgery

الوصف: Objective:Semantic verbal fluency (SVF) tasks require individuals to name items from a specified category within a fixed time. An impaired SVF performance is well documented in patients with amnestic Mild Cognitive Impairment (aMCI). The two leading theoretical views suggest either loss of semantic knowledge or impaired executive control to be responsible.Method:We assessed SVF 3 times on 2 consecutive days in 29 healthy controls (HC) and 29 patients with aMCI with the aim to answer the question which of the two views holds true.Results:When doing the task for the first time, patients with aMCI produced fewer and more common words with a shorter mean response latency. When tested repeatedly, only healthy volunteers increased performance. Likewise, only the performance of HC indicated two distinct retrieval processes: a prompt retrieval of readily available items at the beginning of the task and an active search through semantic space towards the end. With repeated assessment, the pool of readily available items became larger in HC, but not patients with aMCI.Conclusion:The production of fewer and more common words in aMCI points to a smaller search set and supports the loss of semantic knowledge view. The failure to improve performance as well as the lack of distinct retrieval processes point to an additional impairment in executive control. Our data did not clearly favour one theoretical view over the other, but rather indicates that the impairment of patients with aMCI in SVF is due to a combination of both.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ce4e29fbe653cb195d5c036779cfb4Test

المؤلفون: Pascale Lemoine, Philippe Robert, Vincent Bultingaire, Alexandra König, Nicklas Linz, Radia Zeghari, Rachid Guerchouche, Inez H.G.B. Ramakers

المصدر: Alzheimer's & Dementia. 16

مصطلحات موضوعية: 0303 health sciences, Telemedicine, Epidemiology, business.industry, Remote patient monitoring, Health Policy, medicine.disease, 03 medical and health sciences, Psychiatry and Mental health, Cellular and Molecular Neuroscience, 0302 clinical medicine, Developmental Neuroscience, Medicine, Dementia, Neurology (clinical), Medical emergency, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, 030304 developmental biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::0cb638aff51460d2be335b03b85cdca4Test
https://doi.org/10.1002/alz.047345Test