المؤلفون: Reinecke, A, Filippini, N, Berna, C, Western, D G, Hanson, B, Cooper, M J, Taggart, P, Harmer, C J

المصدر: Translational Psychiatry ; volume 5, issue 11, page e673-e673 ; ISSN 2158-3188

مصطلحات موضوعية: Biological Psychiatry, Cellular and Molecular Neuroscience, Psychiatry and Mental health

الوصف: Impairments in emotion regulation are thought to have a key role in the pathogenesis of anxiety disorders, but the neurobiological underpinnings contributing to vulnerability remain poorly understood. It has been a long-held view that exaggerated fear is linked to hyperresponsivity of limbic brain areas and impaired recruitment of prefrontal control. However, increasing evidence suggests that prefrontal–cortical networks are hyperactive during threat processing in anxiety disorders. This study directly explored limbic–prefrontal neural response, connectivity and heart-rate variability (HRV) in patients with a severe anxiety disorder during incidental versus intentional emotion regulation. During 3 Tesla functional magnetic resonance imaging, 18 participants with panic disorder and 18 healthy controls performed an emotion regulation task. They either viewed negative images naturally (Maintain), or they were instructed to intentionally downregulate negative affect using previously taught strategies of cognitive reappraisal (Reappraisal). Electrocardiograms were recorded throughout to provide a functional measure of regulation and emotional processing. Compared with controls, patients showed increased neural activation in limbic–prefrontal areas and reduced HRV during incidental emotion regulation (Maintain). During intentional regulation (Reappraisal), group differences were significantly attenuated. These findings emphasize patients’ ability to regulate negative affect if provided with adaptive strategies. They also bring prefrontal hyperactivation forward as a potential mechanism of psychopathology in anxiety disorders. Although these results challenge models proposing impaired allocation of prefrontal resources as a key characteristic of anxiety disorders, they are in line with more recent neurobiological frameworks suggesting that prefrontal hyperactivation might reflect increased utilisation of maladaptive regulation strategies quintessential for anxiety disorders.

الإتاحة: https://doi.org/10.1038/tp.2015.160Test
https://www.nature.com/articles/tp2015160.pdfTest
https://www.nature.com/articles/tp2015160Test

المؤلفون: De Cates, A., Wright, L., Martens, M., Gibson, D., Turkmen, C., Filippini, N., Cowen, P., Harmer, C., Murphy, S.

المساهمون: Wellcome Trust

المصدر: European Neuropsychopharmacology ; volume 44, page S43-S44 ; ISSN 0924-977X

مصطلحات موضوعية: Pharmacology (medical), Biological Psychiatry, Psychiatry and Mental health, Neurology (clinical), Neurology, Pharmacology

الإتاحة: https://doi.org/10.1016/j.euroneuro.2021.01.067Test
https://api.elsevier.com/content/article/PII:S0924977X21000833?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0924977X21000833?httpAccept=text/plainTest

المؤلفون: Mannie, Z. N., Filippini, N., Williams, C., Near, J., Mackay, C. E., Cowen, P. J.

المصدر: Psychological Medicine ; volume 44, issue 14, page 2939-2948 ; ISSN 0033-2917 1469-8978

مصطلحات موضوعية: Psychiatry and Mental health, Applied Psychology

الوصف: Background Major depression is associated with abnormalities in the function and structure of the hippocampus. However, it is unclear whether these abnormalities might also be present in people ‘at risk’ of illness. Method We studied 62 young people (mean age 18.8 years) at familial risk of depression (FH+) but who had never been depressed themselves. Participants underwent magnetic resonance imaging to assess hippocampal structure and neural responses to a task designed to activate hippocampal memory networks. Magnetic resonance spectroscopy was used to measure levels of a combination of glutamine and glutamate (Glx) in the right hippocampus. A total of 59 matched controls with no history of mood disorder in a first-degree relative underwent the same investigations. Results Hippocampal volume did not differ between FH+ participants and controls; however, relative to controls, during the memory task, FH+ participants showed increased activation in brain regions encompassing the insular cortices, putamen and pallidum as well as the dorsal anterior cingulate cortex (ACC). FH+ participants also had increased hippocampal levels of Glx. Conclusions Euthymic individuals with a parental history of depression demonstrate increased activation of hippocampal-related neural networks during a memory task, particularly in brain regions involved in processing the salience of stimuli. Changes in the activity of the ACC replicate previous findings in FH+ participants using different psychological tasks; this suggests that task-related abnormalities in the ACC may be a marker of vulnerability to depression. Increased levels of Glx in the hippocampus might also represent a risk biomarker but follow-up studies will be required to test these various possibilities.

الإتاحة: https://doi.org/10.1017/s0033291714000580Test
https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0033291714000580Test

المؤلفون: Godlewska, B., Filippini, N., Harmer, C.J., Martens, M., Cowen, P.J.

المصدر: European Neuropsychopharmacology ; volume 40, page S160-S161 ; ISSN 0924-977X

مصطلحات موضوعية: Pharmacology (medical), Biological Psychiatry, Psychiatry and Mental health, Neurology (clinical), Neurology, Pharmacology

الإتاحة: https://doi.org/10.1016/j.euroneuro.2020.09.210Test
https://api.elsevier.com/content/article/PII:S0924977X20304831?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0924977X20304831?httpAccept=text/plainTest

المؤلفون: McCabe, C, Mishor, Z, Filippini, N, Cowen, P J, Taylor, M J, Harmer, C J

المصدر: Molecular Psychiatry ; volume 16, issue 6, page 592-594 ; ISSN 1359-4184 1476-5578

مصطلحات موضوعية: Cellular and Molecular Neuroscience, Psychiatry and Mental health, Molecular Biology

الإتاحة: https://doi.org/10.1038/mp.2010.138Test
https://www.nature.com/articles/mp2010138.pdfTest
https://www.nature.com/articles/mp2010138Test

المؤلفون: Heise, V, Filippini, N, Ebmeier, K P, Mackay, C E

المصدر: Molecular Psychiatry ; volume 16, issue 9, page 908-916 ; ISSN 1359-4184 1476-5578

مصطلحات موضوعية: Cellular and Molecular Neuroscience, Psychiatry and Mental health, Molecular Biology

الإتاحة: https://doi.org/10.1038/mp.2010.90Test
https://www.nature.com/articles/mp201090.pdfTest
https://www.nature.com/articles/mp201090Test

المؤلفون: Pflanz, C.P., Pringle, A., Filippini, N., Warren, M., Gottwald, J., Harmer, C.J., Cowen, P.J.

المصدر: European Neuropsychopharmacology ; volume 24, page S311 ; ISSN 0924-977X

مصطلحات موضوعية: Pharmacology (medical), Biological Psychiatry, Psychiatry and Mental health, Neurology (clinical), Neurology, Pharmacology

الإتاحة: https://doi.org/10.1016/s0924-977xTest(14)70493-6
https://api.elsevier.com/content/article/PII:S0924977X14704936?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0924977X14704936?httpAccept=text/plainTest

المؤلفون: Filippini, N., Douaud, G., Mackay, C. E., Knight, S., Talbot, K., Turner, M. R.

المصدر: Journal of Neurology, Neurosurgery & Psychiatry ; volume 81, issue 11, page e19-e20 ; ISSN 0022-3050

مصطلحات موضوعية: Psychiatry and Mental health, Neurology (clinical), Surgery

الإتاحة: https://doi.org/10.1136/jnnp.2010.226340.12Test

المؤلفون: Cl, Allan, Ce, Sexton, Filippini N, Topiwala A, Mahmood A, Zsoldos E, Singh-Manoux A, Mj, Shipley, Kivimaki M, Ce, Mackay, Klaus Ebmeier

المصدر: Europe PubMed Central

مصطلحات موضوعية: Clinical Psychology, Psychiatry and Mental health, Grey matter, Magnetic resonance imaging, Depression, White matter, Brain

الوصف: Background. Late-life sub-threshold depressive symptoms (i.e. depressive symptoms that do not meet the criteria for a diagnosis of major depressive disorder) are associated with impaired physical health and function, and increased risk of major depressive disorder. Magnetic resonance imaging (MRI) studies examining late-life major depressive disorder find structural brain changes in grey and white matter. However, the extent to which late-life sub-threshold depression is associated with similar hallmarks is not well established. Methods. Participants with no history of major depressive disorder were selected from the Whitehall Imaging Sub-Study (n=358, mean age 69±5 years, 17% female). Depressive symptoms were measured using the Centre for Epidemiological Studies Depression Scale (CESD) at three previous Whitehall II Study phases (2003-04, 2007-09 and 2012-13) and at the time of the MRI scan (2012- 14). The relationships between current and cumulative depressive symptoms and MRI brain measures were explored using Voxel-Based Morphometry (VBM) for grey matter and Tract Based Spatial Statistics (TBSS) for white matter. Results. Current sub-threshold depressive symptoms were associated with significant reductions in fractional anisotropy and increases in axial and radial diffusivity. There were no significant relationships between current depressive symptoms and grey matter measures, or cumulative depressive symptoms and MRI measures. Limitations. The prevalence (10%) of sub-threshold depressive symptoms means that analyses may be underpowered to detect subtle differences in brain structure. Conclusions. Current sub-threshold depressive symptoms are associated with changes in white matter microstructure, indicating that even mild depressive symptoms are associated with similar MRI hallmarks to those in major depressive disorder.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::932784854c53fecda36e47711af7c54aTest

المؤلفون: Mauro Ercolani, Francesca Benuzzi, Fernando Rizzello, A. Bertani, Alessandro Agostini, Rosy Tambasco, Nicola Filippini, Donatella Riso, Valentina Farinelli, Chiara Leoni, A. Scarcelli, Paolo Frigio Nichelli, Carlo Calabrese, Massimo Campieri, Paolo Gionchetti

المساهمون: Agostini A, Filippini N, Benuzzi F, Bertani A, Scarcelli A, Leoni C, Farinelli V, Riso D, Tambasco R, Calabrese C, Rizzello F, Gionchetti P, Ercolani M, Nichelli P, Campieri M

المصدر: Journal of behavioral medicine. 36(5)

مصطلحات موضوعية: Adult, Male, Chron's disease, IBD, Physiology, Hippocampus, Neuropsychological Tests, Amygdala, Developmental psychology, HABITUATION, stress, PSYCHOLOGICAL STRESS, Crohn Disease, Functional neuroimaging, medicine, Humans, Habituation, Habituation, Psychophysiologic, General Psychology, FUNCTIONAL MAGNETIC RESONANCE IMAGING (FMRI), medicine.diagnostic_test, Putamen, Functional Neuroimaging, fMRI, Brain, Magnetic resonance imaging, Magnetic Resonance Imaging, Psychiatry and Mental health, medicine.anatomical_structure, Female, Functional magnetic resonance imaging, Psychology, Insula, Stress, Psychological, CROHN’S DISEASE, MRI

الوصف: In patients with Crohn's disease (CD) stress is believed to increase the incidence of disease relapse. The brain processes stressful stimuli and triggers the stress-evoked responses. Habituation to stress is an adaptive process that allows minimizing these responses. We hypothesized inadequate habituation to stress in CD patients. The aim of this study was to compare the neural habituation between CD patients and controls. Twenty CD patients and eighteen controls underwent a functional magnetic resonance imaging while performing two repeated runs of a stress-evoking task. The task elicited different neural activity between the groups across runs in (1) amygdala, hippocampus, (2) insula, putamen (3) cerebellar regions, suggesting altered habituation to stress in patients. These structures regulate the neuroendocrine and autonomic stress-evoked responses that control the proinflammatory responses. The inadequate habituation to stress that we found in patients could play a role in the relationship between stress and inflammatory exacerbations in CD.

وصف الملف: STAMPA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9bd5f6ea4bd094755d69dbb5e8bd151Test
https://pubmed.ncbi.nlm.nih.gov/22752251Test