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1دورية أكاديمية
المؤلفون: Simonetti A., Luciano M., Sampogna G., Rocca B. D., Mancuso E., De Fazio P., Di Nicola M., Di Lorenzo G., Pepe M., Sambataro F., Signorelli M. S., Koukopoulos A. E., Chiaie R. D., Fiorillo A., Sani G.
المساهمون: Simonetti, A., Luciano, M., Sampogna, G., Rocca, B. D., Mancuso, E., De Fazio, P., Di Nicola, M., Di Lorenzo, G., Pepe, M., Sambataro, F., Signorelli, M. S., Koukopoulos, A. E., Chiaie, R. D., Fiorillo, A., Sani, G.
مصطلحات موضوعية: Bipolar disorder, Course, Diagnosi, Major affective disorder, Temperament, psy, edu
الوصف: Background: Affective temperaments represent the stable, biologically determined substrates of mood disorders. The relationship between affective temperaments and bipolar disorder (BD) or major depressive disorder (MDD) has been described. However, the strength of such relationship should be tested while considering other factors influencing the diagnosis of BD/MDD. Literature also lacks a comprehensive description of the interplay between affective temperament and characteristics of mood disorders. The aim of the present study is to address these issues. Methods: This is a multicentric observational study including 7 Italian university sites. Five-hundred-fifty-five euthymic subjects with BD/MDD were enrolled and further divided in those with hyperthymic (Hyper, N = 143), cyclothymic (Cyclo, N = 133), irritable (Irr, N = 49), dysthymic (Dysth, N = 155), and anxious (Anx N = 76) temperaments. Linear, binary, ordinal and logistic regressions were performed to assess the association between affective temperaments and i) diagnosis of BD/MDD; ii) characteristics of illness severity and course. Results: Hyper, Cyclo and Irr were more likely to be associated with BD, together with earlier age of onset and presence of a first-degree relative with BD. Anx and Dysth were more associated with MDD. Differences in association between affective temperaments and characteristics of BD/MDD were observed for hospital admissions, phase-related psychotic symptoms, length and type of depression, comorbidity and pharmacological intake. Limitations: Small sample size, cross-sectional design, recall biases. Conclusion: Specific affective temperaments were associated to certain characteristics of illness severity and course of BD or MDD. Evaluation of affective temperaments might help a deeper understanding of mood disorders.
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2دورية أكاديمية
المؤلفون: Natale, A., Fusar-Poli, L., Sturiale, S., Placenti, V., Marino, M., Amerio, A., Rodolico, A., Concerto, C., Aguglia, A., Petralia, A., Signorelli, M. S., Serafini, G., Amore, M., Aguglia, E.
المصدر: Eur Psychiatry
الوصف: INTRODUCTION: People with mental disorders may present impairments in cognitive and metacognitive functions. Self-reflection is the ability to reflect on oneself (specifically on one’s behavior, emotions, and thoughts) and insight is the awareness of one’s internal experience. Mindwandering (MW) is defined as the tendency to divert attention from current reality without a clearly defined intention. It can be spontaneous or deliberate. Several studies have investigated these alterations in patients with schizophrenia (SZ), while less is known for people with substance use disorder (SUD). OBJECTIVES: The aim of the present study was to explore self-reflection, insight and MW in a group of patients with SZ and SUD. METHODS: The Self-reflection and Insight Scale (SRIS) and the spontaneous (MW-S) and deliberate (MW-D) mindwandering scales were administered to 25 patients with SZ, 21 patients with SUD, and 21 healthy controls (HC). Linear regressions were performed to evaluate the associations between the variables under study. RESULTS: Preliminary data showed that SZ and SUD patients presented lower SRIS and MW values than HC. Examining MW in detail, participants with SZ reported higher scores at than MW-D, while in people with SUD, MW-D scores were higher than MW-S scores. Linear regressions revealed that MW-D was negatively associated with self-reflection in SUD; moreover, insight scores were negatively associated with MW-S in SZ. CONCLUSIONS: Our preliminary results confirm the importance of acting on the elements of metacognition in patients with mental disorders to improve the general outcome of the disease. A comprehensive therapeutic approach should include psychotherapeutic and social interventions aimed at increasing attention and introspection. DISCLOSURE OF INTEREST: None Declared
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3دورية أكاديمية
المؤلفون: Bartoli F., Cavaleri D., Callovini T., Riboldi I., Crocamo C., D'Agostino A., Martinotti G., Bertolini F., Ostuzzi G., Barbui C., Carra G., Boschello F., Gastaldon C., Mazzi M. A., Nose M., Papola D., Perini G., Piccoli A., Pievani M., Purgato M., Ruggeri M., Tedeschi F., Terlizzi S., Turrini G., Caroleo M., De Fazio P., Magliocco F., Raffaele G., Chirico M., Ferrato F., Limosani I., Mastromo D., Monzani E., Ostinelli E. G., Porcellana M., Restaino F., Annese P. M., Bolognesi S., Cerretini M., De Capua A., Debolini S., Del Zanna M., Fargnoli F., Giannini A., Luccarelli L., Lucii C., Pierantozzi E., Tozzi F., Bardicchia F., Cardamone G., Facchi E., Magnani N., Soscia F., Biancosino B., Zotos S., Giacomin M., Pompei F., Spano M., Zonta F., Buzzi A., Callegari C., Calzolari R., Caselli I., Diurni M., Giana E. L., Ielmini M., Milano A., Poloni N., Sani E., Zizolfi D., Alberini G., Bortolaso P., Cazzamalli S., Costantini C., Di Caro A., Paronelli C., Piantanida S., Piccinelli M., Alessandro P., Barbanti S. V., D'Ippolito C., Gozzi M., Moretti V., Corbo M., Di Capro L., di Giannantonio M., Fiori F., Lorusso M., Mancini V., Viceconte D., Calandra C., Luca M., Signorelli M. S., Suraniti F., Balzarro B., Boncompagni G., Caretto V., Emiliani R., Lupoli P., Menchetti M., Rossi E., Storbini V., Tarricone I., Terzi L., Boso M., Catania C., De Paoli G., Risaro P., Aspesi F., Bava M., Bono A., Brambilla G., Castagna G., Lucchi S., Nava R., Provenzi M., Tabacchi T., Tremolada M., Verrengia E., Barchiesi M., Oriani M. G., Aguglia A., Ferro M., Ghio L., Beneduce R., Laffranchini L., Magni L. R., Rossi G., Tura G. B., Addeo L., Balletta G., De Vivo E., Di Benedetto R., Parise V. F., Carpiniello B., Pinna F., Pecile D., Mattei C., Bonavigo T., Fabrici E. P., Panarello S., Peresson G., Vitucci C., Pacetti M., Gardellin F., Strizzolo S., Cossetta E., Fizzotti C., Moretti D., Di Gregorio L., Sozzi F., Colli G., La Barbera D., Laurenzi S.
المساهمون: Bartoli, F., Cavaleri, D., Callovini, T., Riboldi, I., Crocamo, C., D'Agostino, A., Martinotti, G., Bertolini, F., Ostuzzi, G., Barbui, C., Carra, G., Boschello, F., Gastaldon, C., Mazzi, M. A., Nose, M., Papola, D., Perini, G., Piccoli, A., Pievani, M., Purgato, M., Ruggeri, M., Tedeschi, F., Terlizzi, S., Turrini, G., Caroleo, M., De Fazio, P., Magliocco, F., Raffaele, G., Chirico, M., Ferrato, F., Limosani, I., Mastromo, D., Monzani, E., Ostinelli, E. G., Porcellana, M., Restaino, F., Annese, P. M., Bolognesi, S., Cerretini, M., De Capua, A., Debolini, S., Del Zanna, M., Fargnoli, F., Giannini, A., Luccarelli, L., Lucii, C., Pierantozzi, E., Tozzi, F., Bardicchia, F., Cardamone, G., Facchi, E., Magnani, N., Soscia, F., Biancosino, B., Zotos, S., Giacomin, M., Pompei, F., Spano, M., Zonta, F., Buzzi, A., Callegari, C., Calzolari, R., Caselli, I., Diurni, M., Giana, E. L., Ielmini, M., Milano, A., Poloni, N., Sani, E., Zizolfi, D., Alberini, G., Bortolaso, P., Cazzamalli, S., Costantini, C., Di Caro, A., Paronelli, C., Piantanida, S., Piccinelli, M., Alessandro, P., Barbanti, S. V., D'Ippolito, C., Gozzi, M., Moretti, V., Corbo, M., Di Capro, L., di Giannantonio, M., Fiori, F., Lorusso, M., Mancini, V., Viceconte, D., Calandra, C., Luca, M., Signorelli, M. S., Suraniti, F., Balzarro, B., Boncompagni, G., Caretto, V., Emiliani, R., Lupoli, P., Menchetti, M.
مصطلحات موضوعية: Aripiprazole monohydrate, Long-acting injectable antipsychotic, Paliperidone palmitate 1-month, Aripiprazole, Human, Paliperidone palmitate, Prospective studie, Antipsychotic agent, Schizophrenia, manag, psy
الوصف: In this prospective study, we assessed the effectiveness and acceptability of paliperidone palmitate 1-month (PP1M) and aripiprazole monohydrate (AM) over 1-year follow-up. We included 195 subjects (117 treated with PP1M and 78 with AM) with schizophrenia spectrum disorders from real-world settings. We estimated no differences in hospitalization (Odds Ratio=1.59; p = 0.12), symptoms improvement (p = 0.90 adjusted for baseline severity), and discontinuation (Hazard Ratio=0.72; p = 0.20) at study endpoint. Although current evidence suggests the possible superiority of AM over PP1M, our findings showed comparable effectiveness between these drugs. Additional studies in real-world settings with direct comparisons between these two LAIs are needed.
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4دورية أكاديمية
المؤلفون: Pompili M., Erbuto D., Innamorati M., Luciano M., Sampogna G., Abbate-Daga G., Barlati S., Carmassi C., Castellini G., De Fazio P., Di Lorenzo G., Di Nicola M., Ferrari S., Gramaglia C., Nanni M. G., Pasquini M., Pinna F., Poloni N., Serafini G., Signorelli M., Ventriglio A., Volpe U., Fiorillo A.
المساهمون: Pompili, M., Erbuto, D., Innamorati, M., Luciano, M., Sampogna, G., Abbate-Daga, G., Barlati, S., Carmassi, C., Castellini, G., De Fazio, P., Di Lorenzo, G., Di Nicola, M., Ferrari, S., Gramaglia, C., Nanni, M. G., Pasquini, M., Pinna, F., Poloni, N., Serafini, G., Signorelli, M., Ventriglio, A., Volpe, U., Fiorillo, A.
الوصف: Objective: Mental pain and exposure to maltreatment are significant risk factors for suicidal behavior. This study aimed to investigate whether mental pain could be associated with a recent suicide attempt and whether it could mediate the relationship between childhood traumatic experiences and suicide risk in psychiatric patients. Methods: A multicenter observational study was organized as a joint project with representatives of numerous mixed Italian academic and clinical settings. Between December 2017 and March 2020, batteries of tests were administered to patients, assessing suicidal ideation and behavior, mental pain (usual and worst mental pain in the past 15 days), depression, and childhood maltreatment. Results: A total of 2,137 psychiatric patients (1,313 women and 824 men) were included in the final sample, and 315 reported having attempted suicide in the last 3 months. Suicide attempters (compared to nonattempters) had higher odds of reporting worse mental pain (odds ratios [ORs] between 1.02 and 1.17; P < .001) and suicidal intent with/without a specific plan (ORs between 11.57 and 11.77; P < .001). They also had higher odds of having a personality disorder (borderline personality disorder: ORs between 2.65 and 3.01; P < .001; other personality disorders: ORs between 1.96 and 2.28; P < .01) and major depression (ORs between 1.62 and 1.70; P < .05). Childhood trauma was associated with suicide risk directly (standardized effects between 0.06 and 0.07; P< .01) and indirectly through mental pain (usual mental pain: standardized indirect effect = 0.11, P < .001; worst mental pain in the past 15 days: standardized indirect effect = 0.12, P < .001). Conclusions: Mental pain constitutes a crucial framework for assessing the individual need for psychiatric help. Assessing mental pain allows identification of the main ingredient of suicide risk and puts the clinician in a strategic position to unlock some motives behind the wish to die. Further research is needed to learn if childhood ...
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5دورية أكاديمية
المؤلفون: Pompili M., Erbuto D., Innamorati M., Luciano M., Sampogna G., Abbate-Daga G., Barlati S., Carmassi C., Castellini G., De Fazio P., Di Lorenzo G., Di Nicola M., Ferrari S., Gramaglia C., Nanni M. G., Pasquini M., Pinna F., Poloni N., Serafini G., Signorelli M., Ventriglio A., Volpe U., Fiorillo A.
المساهمون: Pompili, M., Erbuto, D., Innamorati, M., Luciano, M., Sampogna, G., Abbate-Daga, G., Barlati, S., Carmassi, C., Castellini, G., De Fazio, P., Di Lorenzo, G., Di Nicola, M., Ferrari, S., Gramaglia, C., Nanni, M. G., Pasquini, M., Pinna, F., Poloni, N., Serafini, G., Signorelli, M., Ventriglio, A., Volpe, U., Fiorillo, A.
الوصف: Objective: Mental pain and exposure to maltreatment are significant risk factors for suicidal behavior. This study aimed to investigate whether mental pain could be associated with a recent suicide attempt and whether it could mediate the relationship between childhood traumatic experiences and suicide risk in psychiatric patients. Methods: A multicenter observational study was organized as a joint project with representatives of numerous mixed Italian academic and clinical settings. Between December 2017 and March 2020, batteries of tests were administered to patients, assessing suicidal ideation and behavior, mental pain (usual and worst mental pain in the past 15 days), depression, and childhood maltreatment. Results: A total of 2,137 psychiatric patients (1,313 women and 824 men) were included in the final sample, and 315 reported having attempted suicide in the last 3 months. Suicide attempters (compared to nonattempters) had higher odds of reporting worse mental pain (odds ratios [ORs] between 1.02 and 1.17; P < .001) and suicidal intent with/without a specific plan (ORs between 11.57 and 11.77; P < .001). They also had higher odds of having a personality disorder (borderline personality disorder: ORs between 2.65 and 3.01; P < .001; other personality disorders: ORs between 1.96 and 2.28; P < .01) and major depression (ORs between 1.62 and 1.70; P < .05). Childhood trauma was associated with suicide risk directly (standardized effects between 0.06 and 0.07; P< .01) and indirectly through mental pain (usual mental pain: standardized indirect effect = 0.11, P < .001; worst mental pain in the past 15 days: standardized indirect effect = 0.12, P < .001). Conclusions: Mental pain constitutes a crucial framework for assessing the individual need for psychiatric help. Assessing mental pain allows identification of the main ingredient of suicide risk and puts the clinician in a strategic position to unlock some motives behind the wish to die. Further research is needed to learn if childhood ...
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6دورية أكاديمية
المؤلفون: Pompili M., Erbuto D., Innamorati M., Luciano M., Sampogna G., Abbate-Daga G., Barlati S., Carmassi C., Castellini G., De Fazio P., Di Lorenzo G., Di Nicola M., Ferrari S., Gramaglia C., Nanni M. G., Pasquini M., Pinna F., Poloni N., Serafini G., Signorelli M., Ventriglio A., Volpe U., Fiorillo A.
المساهمون: Pompili, M., Erbuto, D., Innamorati, M., Luciano, M., Sampogna, G., Abbate-Daga, G., Barlati, S., Carmassi, C., Castellini, G., De Fazio, P., Di Lorenzo, G., Di Nicola, M., Ferrari, S., Gramaglia, C., Nanni, M. G., Pasquini, M., Pinna, F., Poloni, N., Serafini, G., Signorelli, M., Ventriglio, A., Volpe, U., Fiorillo, A.
الوصف: Objective: Mental pain and exposure to maltreatment are significant risk factors for suicidal behavior. This study aimed to investigate whether mental pain could be associated with a recent suicide attempt and whether it could mediate the relationship between childhood traumatic experiences and suicide risk in psychiatric patients. Methods: A multicenter observational study was organized as a joint project with representatives of numerous mixed Italian academic and clinical settings. Between December 2017 and March 2020, batteries of tests were administered to patients, assessing suicidal ideation and behavior, mental pain (usual and worst mental pain in the past 15 days), depression, and childhood maltreatment. Results: A total of 2,137 psychiatric patients (1,313 women and 824 men) were included in the final sample, and 315 reported having attempted suicide in the last 3 months. Suicide attempters (compared to nonattempters) had higher odds of reporting worse mental pain (odds ratios [ORs] between 1.02 and 1.17; P < .001) and suicidal intent with/without a specific plan (ORs between 11.57 and 11.77; P < .001). They also had higher odds of having a personality disorder (borderline personality disorder: ORs between 2.65 and 3.01; P < .001; other personality disorders: ORs between 1.96 and 2.28; P < .01) and major depression (ORs between 1.62 and 1.70; P < .05). Childhood trauma was associated with suicide risk directly (standardized effects between 0.06 and 0.07; P< .01) and indirectly through mental pain (usual mental pain: standardized indirect effect = 0.11, P < .001; worst mental pain in the past 15 days: standardized indirect effect = 0.12, P < .001). Conclusions: Mental pain constitutes a crucial framework for assessing the individual need for psychiatric help. Assessing mental pain allows identification of the main ingredient of suicide risk and puts the clinician in a strategic position to unlock some motives behind the wish to die. Further research is needed to learn if childhood ...
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7دورية أكاديمية
المؤلفون: Pompili M., Erbuto D., Innamorati M., Luciano M., Sampogna G., Abbate-Daga G., Barlati S., Carmassi C., Castellini G., De Fazio P., Di Lorenzo G., Di Nicola M., Ferrari S., Gramaglia C., Nanni M. G., Pasquini M., Pinna F., Poloni N., Serafini G., Signorelli M., Ventriglio A., Volpe U., Fiorillo A.
المساهمون: Pompili, M., Erbuto, D., Innamorati, M., Luciano, M., Sampogna, G., Abbate-Daga, G., Barlati, S., Carmassi, C., Castellini, G., De Fazio, P., Di Lorenzo, G., Di Nicola, M., Ferrari, S., Gramaglia, C., Nanni, M. G., Pasquini, M., Pinna, F., Poloni, N., Serafini, G., Signorelli, M., Ventriglio, A., Volpe, U., Fiorillo, A.
الوصف: Objective: Mental pain and exposure to maltreatment are significant risk factors for suicidal behavior. This study aimed to investigate whether mental pain could be associated with a recent suicide attempt and whether it could mediate the relationship between childhood traumatic experiences and suicide risk in psychiatric patients. Methods: A multicenter observational study was organized as a joint project with representatives of numerous mixed Italian academic and clinical settings. Between December 2017 and March 2020, batteries of tests were administered to patients, assessing suicidal ideation and behavior, mental pain (usual and worst mental pain in the past 15 days), depression, and childhood maltreatment. Results: A total of 2,137 psychiatric patients (1,313 women and 824 men) were included in the final sample, and 315 reported having attempted suicide in the last 3 months. Suicide attempters (compared to nonattempters) had higher odds of reporting worse mental pain (odds ratios [ORs] between 1.02 and 1.17; P < .001) and suicidal intent with/without a specific plan (ORs between 11.57 and 11.77; P < .001). They also had higher odds of having a personality disorder (borderline personality disorder: ORs between 2.65 and 3.01; P < .001; other personality disorders: ORs between 1.96 and 2.28; P < .01) and major depression (ORs between 1.62 and 1.70; P < .05). Childhood trauma was associated with suicide risk directly (standardized effects between 0.06 and 0.07; P< .01) and indirectly through mental pain (usual mental pain: standardized indirect effect = 0.11, P < .001; worst mental pain in the past 15 days: standardized indirect effect = 0.12, P < .001). Conclusions: Mental pain constitutes a crucial framework for assessing the individual need for psychiatric help. Assessing mental pain allows identification of the main ingredient of suicide risk and puts the clinician in a strategic position to unlock some motives behind the wish to die. Further research is needed to learn if childhood ...
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8دورية أكاديمية
المؤلفون: Aguglia A., Fusar-Poli L., Amerio A., Placenti V., Concerto C., Martinotti G., Carra G., Bartoli F., D'Agostino A., Serafini G., Amore M., Aguglia E., Ostuzzi G., Barbui C., Nose' M., Purgato M., Turrini G., Mazzi M. A., Papola D., Gastaldon C., Terlizzi S., Bertolini F., Piccoli A., Ruggeri M., De Fazio P., Magliocco F., Caroleo M., Raffaele G., Ostinelli E. G., Chirico M., Cavallotti S., Lucii C., Bolognesi S., Debolini S., Pierantozzi E., Fargnoli F., Del Zanna M., Giannini A., Luccarelli L., De Capua A., Annese P. M., Cerretini M., Tozzi F., Magnani N., Cardamone G., Bardicchia F., Facchi E., Soscia F., Zotos S., Biancosino B., Zonta F., Pompei F., Callegari C., Zizolfi D., Poloni N., Ielmini M., Caselli I., Giana E., Buzzi A., Diurni M., Milano A., Sani E., Calzolari R., Bortolaso P., Piccinelli M., Cazzamalli S., Alberini G., Piantanida S., Costantini C., Paronelli C., Di Caro A., Moretti V., Gozzi M., D'Ippolito C., Barbanti S. V., Alessandro P., Corbo M., Campese O., Fiori F., Lorusso M., Di Capro L., Viceconte D., Mancini V., Suraniti F., Signorelli M. S., Rossi E., Lupoli P., Menchetti M., Terzi L., Boso M., Risaro P., De Paoli G., Catania C., Tarricone I., Caretto V., Storbini V., Emiliani R., Balzarro B., Tabacchi T., Nava R., Bono A., Provenzi M., Brambilla G., Aspesi F., Trotta, Tremolada M., Castagna G., Bava M., Verrengia E., Lucchi S., Oriani M. G., Barchiesi M., Pacetti M., Magni L. R., Rossi G., Beneduce R., Tura G. B., Laffranchini L., Mastromo D., Ferrato F., Restaino F., Monzani E., Porcellana M., Limosani I., Ghio L., Ferro M., Parise V. F., Balletta G., Addeo L., De Vivo E., Di Benedetto R., Pinna F., Carpiniello B., Spano M., Giacomin M., Pecile D., Mattei C., Fabrici E. P., Panarello S., Peresson G., Vitucci C., Bonavigo T., Perini G., Boschello F., Strizzolo S., Gardellin F., di Giannantonio M., Moretti D., Fizzotti C., Cossetta E., Di Gregorio L., Sozzi F., Boncompagni G., La Barbera D., Colli G., Laurenzi S., Calandra C., Luca M.
المساهمون: Aguglia, A., Fusar-Poli, L., Amerio, A., Placenti, V., Concerto, C., Martinotti, G., Carra, G., Bartoli, F., D'Agostino, A., Serafini, G., Amore, M., Aguglia, E., Ostuzzi, G., Barbui, C., Nose', M., Purgato, M., Turrini, G., Mazzi, M. A., Papola, D., Gastaldon, C., Terlizzi, S., Bertolini, F., Piccoli, A., Ruggeri, M., De Fazio, P., Magliocco, F., Caroleo, M., Raffaele, G., Ostinelli, E. G., Chirico, M., Cavallotti, S., Lucii, C., Bolognesi, S., Debolini, S., Pierantozzi, E., Fargnoli, F., Del Zanna, M., Giannini, A., Luccarelli, L., De Capua, A., Annese, P. M., Cerretini, M., Tozzi, F., Magnani, N., Cardamone, G., Bardicchia, F., Facchi, E., Soscia, F., Zotos, S., Biancosino, B., Zonta, F., Pompei, F., Callegari, C., Zizolfi, D., Poloni, N., Ielmini, M., Caselli, I., Giana, E., Buzzi, A., Diurni, M., Milano, A., Sani, E., Calzolari, R., Bortolaso, P., Piccinelli, M., Cazzamalli, S., Alberini, G., Piantanida, S., Costantini, C., Paronelli, C., Di Caro, A., Moretti, V., Gozzi, M., D'Ippolito, C., Barbanti, S. V., Alessandro, P., Corbo, M., Campese, O., Fiori, F., Lorusso, M., Di Capro, L., Viceconte, D., Mancini, V., Suraniti, F., Signorelli, M. S., Rossi, E., Lupoli, P., Menchetti, M., Terzi, L., Boso, M., Risaro, P., De Paoli, G., Catania, C., Tarricone, I., Caretto, V., Storbini, V., Emiliani, R., Balzarro, B., Tabacchi, T., Nava, R.
مصطلحات موضوعية: Adherence, Antipsychotic, Attitude, Drug, Long-acting injectable, Psychotic symptom, Therapeutic alliance, psy, lang
الوصف: Background: Long-acting injectable (LAI) antipsychotics are efficacious in managing psychotic symptoms in people affected by severe mental disorders, such as schizophrenia and bipolar disorder. The present study aimed to investigate whether attitude toward treatment and treatment adherence represent predictors of symptoms changes over time. Methods: The STAR Network “Depot Study” was a naturalistic, multicenter, observational, prospective study that enrolled people initiating a LAI without restrictions on diagnosis, clinical severity or setting. Participants from 32 Italian centers were assessed at three time points: baseline, 6-month, and 12-month follow-up. Psychopathological symptoms, attitude toward medication and treatment adherence were measured using the Brief Psychiatric Rating Scale (BPRS), the Drug Attitude Inventory (DAI-10) and the Kemp's 7-point scale, respectively. Linear mixed-effects models were used to evaluate whether attitude toward medication and treatment adherence independently predicted symptoms changes over time. Analyses were conducted on the overall sample and then stratified according to the baseline severity (BPRS < 41 or BPRS ≥ 41). Results: We included 461 participants of which 276 were males. The majority of participants had received a primary diagnosis of a schizophrenia spectrum disorder (71.80%) and initiated a treatment with a second-generation LAI (69.63%). BPRS, DAI-10, and Kemp's scale scores improved over time. Six linear regressions—conducted considering the outcome and predictors at baseline, 6-month, and 12-month follow-up independently—showed that both DAI-10 and Kemp's scale negatively associated with BPRS scores at the three considered time points. Linear mixed-effects models conducted on the overall sample did not show any significant association between attitude toward medication or treatment adherence and changes in psychiatric symptoms over time. However, after stratification according to baseline severity, we found that both DAI-10 and Kemp's scale negatively .
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9دورية أكاديمية
المؤلفون: Barbui C., Nose M., Purgato M., Turrini G., Ostuzzi G., Mazzi M. A., Papola D., Gastaldon C., Terlizzi S., Bertolini F., Piccoli A., Ruggeri M., De Fazio P., Magliocco F., Caroleo M., Raffaele G., D'Agostino A., Ostinelli E. G., Chirico M., Cavallotti S., Lucii C., Bolognesi S., Debolini S., Pierantozzi E., Fargnoli F., Del Zanna M., Giannini A., Luccarelli L., De Capua A., Annese P. M., Cerretini M., Tozzi F., Magnani N., Cardamone G., Bardicchia F., Facchi E., Soscia F., Zotos S., Biancosino B., Zonta F., Pompei F., Callegari C., Zizolfi D., Poloni N., Ielmini M., Caselli I., Giana E., Buzzi A., Diurni M., Milano A., Sani E., Calzolari R., Bortolaso P., Piccinelli M., Cazzamalli S., Alberini G., Piantanida S., Costantini C., Paronelli C., Di Caro A., Moretti V., Gozzi M., D'Ippolito C., Barbanti S. V., Papalini A., Corbo M., Martinotti G., Campese O., Fiori F., Lorusso M., Di Capro L., Viceconte D., Mancini V., Suraniti F., Signorelli M. S., Rossi E., Lupoli P., Menchetti M., Terzi L., Boso M., Risaro P., De Paoli G., Catania C., Tarricone I., Caretto V., Storbini V., Emiliani R., Balzarro B., Carra G., Bartoli F., Tabacchi T., Nava R., Bono A., Provenzi M., Brambilla G., Aspesi F., Trotta G., Tremolada M., Castagna G., Bava M., Verrengia E., Lucchi S., Oriani M. G., Barchiesi M., Pacetti M., Aguglia A., Magni L. R., Rossi G., Beneduce R., Tura G. B., Laffranchini L., Mastromo D., Ferrato F., Restaino F., Monzani E., Porcellana M., Limosani I., Ghio L., Ferro M., Parise V. F., Balletta G., Addeo L., De Vivo E., Di Benedetto R., Pinna F., Carpiniello B., Spano M., Giacomin M., Pecile D., Mattei C., Fabrici E. P., Panarello S., Peresson G., Vitucci C., Bonavigo T., Perini G., Boschello F., Strizzolo S., Gardellin F., Di Giannantonio M., Moretti D., Fizzotti C., Cossetta E., Di Gregorio L., Sozzi F., Boncompagni G., La Barbera D., Colli G., Laurenzi S., Calandra C., Luca M., Crocamo C.
المساهمون: Barbui, C., Nose, M., Purgato, M., Turrini, G., Ostuzzi, G., Mazzi, M. A., Papola, D., Gastaldon, C., Terlizzi, S., Bertolini, F., Piccoli, A., Ruggeri, M., De Fazio, P., Magliocco, F., Caroleo, M., Raffaele, G., D'Agostino, A., Ostinelli, E. G., Chirico, M., Cavallotti, S., Lucii, C., Bolognesi, S., Debolini, S., Pierantozzi, E., Fargnoli, F., Del Zanna, M., Giannini, A., Luccarelli, L., De Capua, A., Annese, P. M., Cerretini, M., Tozzi, F., Magnani, N., Cardamone, G., Bardicchia, F., Facchi, E., Soscia, F., Zotos, S., Biancosino, B., Zonta, F., Pompei, F., Callegari, C., Zizolfi, D., Poloni, N., Ielmini, M., Caselli, I., Giana, E., Buzzi, A., Diurni, M., Milano, A., Sani, E., Calzolari, R., Bortolaso, P., Piccinelli, M., Cazzamalli, S., Alberini, G., Piantanida, S., Costantini, C., Paronelli, C., Di Caro, A., Moretti, V., Gozzi, M., D'Ippolito, C., Barbanti, S. V., Papalini, A., Corbo, M., Martinotti, G., Campese, O., Fiori, F., Lorusso, M., Di Capro, L., Viceconte, D., Mancini, V., Suraniti, F., Signorelli, M. S., Rossi, E., Lupoli, P., Menchetti, M., Terzi, L., Boso, M., Risaro, P., De Paoli, G., Catania, C., Tarricone, I., Caretto, V., Storbini, V., Emiliani, R., Balzarro, B., Carra, G., Bartoli, F., Tabacchi, T., Nava, R., Bono, A., Provenzi, M., Brambilla, G., Aspesi, F., Trotta, G., Tremolada, M., Castagna, G., Bava, M.
مصطلحات موضوعية: Long-acting injectable antipsychotics, Paliperidone palmitate, Schizophrenia, Adult, Antipsychotic Agents, Aripiprazole, Female, Health Knowledge, Attitudes, Practice, Humans, Male, Medication Adherence, Practice Patterns, Physicians', Schizophrenic Psychology, Young Adult, Aripiprazole monohydrate, psy, hisphilso
الوصف: This study, based on the 'Servizi Territoriali Associati per la Ricerca' (STAR) Network Depot Study nationwide baseline data, explored whether individual symptoms severity and clusters might influence the prescription of paliperidone palmitate 1-month (PP1M) vs. aripiprazole monohydrate. The Brief Psychiatric Rating Scale (BPRS) was used to assess psychopathology and relevant symptoms clusters. Drug Attitude Inventory, 10 items, was used to test attitude towards medications. Adherence to treatments was rated according to the Kemp seven-point scale. We assessed for eligibility 451 individuals and, among them, we included 195 subjects (n = 117 who started PPM1 and n = 78 aripiprazole monohydrate). Individuals were comparable in terms of age, gender, treatment years, recent hospitalizations, previous long-acting injectable antipsychotic treatments, additional oral treatments, attitude toward drugs, medication adherence, and alcohol/substance-related comorbidities. Subjects starting PP1M presented higher BPRS overall (P = 0.009), positive (P = 0.015), and negative (P = 0.010) symptom scores compared to subjects starting aripiprazole monohydrate. Results were confirmed by appropriate regression models and propensity score matching analysis. No differences were found comparing the other BPRS subscale scores: affect, resistance, and activation. Clinicians may be more prone to prescribe PPM1, rather than aripiprazole monohydrate, to subjects showing higher overall symptom severity, including positive and negative symptoms. No additional clinical factors influenced prescribing attitudes in our sample.
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10دورية أكاديمية
المؤلفون: Galderisi S., Rucci P., Mucci A., Rossi A., Rocca P., Bertolino A., Aguglia E., Amore M., Bellomo A., Bozzatello P., Bucci P., Carpiniello B., Collantoni E., Cuomo A., Dell'Osso L., Di Fabio F., di Giannantonio M., Gibertoni D., Giordano G. M., Marchesi C., Monteleone P., Oldani L., Pompili M., Roncone R., Rossi R., Siracusano A., Vita A., Zeppegno P., Maj M., Catapano F., Piegari G., Aiello C., Brando F., Giuliani L., Pietrafesa D., Papalino M., Mercadante G., Di Palo P., Barlati S., Deste G., Valsecchi P., Pinna F., Olivieri B., Manca D., Signorelli M. S., Fusar Poli L., De Berardis D., Fraticelli S., Corbo M., Pallanti S., Altamura M., Carnevale R., Malerba S., Calcagno P., Zampogna D., Corso A., Giusti L., Salza A., Ussorio D., Talevi D., Socci V., Pacitti F., de Bartolomeis A., Gramaglia C., Gambaro E., Gattoni E., Favaro A., Tenconi E., Meneguzzo P., Tonna M., Ossola P., Gerra M. L., Carmassi C., Cremone I., Carpita B., Girardi N., Frascarelli M., Buzzanca A., Brugnoli R., Comparelli A., Corigliano V., Di Lorenzo G., Niolu C., Ribolsi M., Corrivetti G., Cascino G., del Buono G., Bolognesi S., Fagiolini A., Goracci A., Bellino S., Montemagni C., Brasso C.
المساهمون: Galderisi, S., Rucci, P., Mucci, A., Rossi, A., Rocca, P., Bertolino, A., Aguglia, E., Amore, M., Bellomo, A., Bozzatello, P., Bucci, P., Carpiniello, B., Collantoni, E., Cuomo, A., Dell'Osso, L., Di Fabio, F., di Giannantonio, M., Gibertoni, D., Giordano, G. M., Marchesi, C., Monteleone, P., Oldani, L., Pompili, M., Roncone, R., Rossi, R., Siracusano, A., Vita, A., Zeppegno, P., Maj, M., Catapano, F., Piegari, G., Aiello, C., Brando, F., Giuliani, L., Pietrafesa, D., Papalino, M., Mercadante, G., Di Palo, P., Barlati, S., Deste, G., Valsecchi, P., Pinna, F., Olivieri, B., Manca, D., Signorelli, M. S., Fusar Poli, L., De Berardis, D., Fraticelli, S., Corbo, M., Pallanti, S., Altamura, M., Carnevale, R., Malerba, S., Calcagno, P., Zampogna, D., Corso, A., Giusti, L., Salza, A., Ussorio, D., Talevi, D., Socci, V., Pacitti, F., de Bartolomeis, A., Gramaglia, C., Gambaro, E., Gattoni, E., Favaro, A., Tenconi, E., Meneguzzo, P., Tonna, M., Ossola, P., Gerra, M. L., Carmassi, C., Cremone, I., Carpita, B., Girardi, N., Frascarelli, M., Buzzanca, A., Brugnoli, R., Comparelli, A., Corigliano, V., Di Lorenzo, G., Niolu, C., Ribolsi, M., Corrivetti, G., Cascino, G., del Buono, G., Bolognesi, S., Fagiolini, A., Goracci, A., Bellino, S., Montemagni, C., Brasso, C.
مصطلحات موضوعية: everyday life skill, functional capacity, internalized stigma, network analysi, personal resource, psychopathology, real-life functioning, recovery, Schizophrenia, psy, socio
الوصف: Improving real-life functioning is the main goal of the most advanced integrated treatment programs in people with schizophrenia. The Italian Network for Research on Psychoses previously explored, by using network analysis, the interplay among illness-related variables, personal resources, context-related factors and real-life functioning in a large sample of patients with schizophrenia. The same research network has now completed a 4-year follow-up of the original sample. In the present study, we used network analysis to test whether the pattern of relationships among all variables investigated at baseline was similar at follow-up. In addition, we compared the network structure of patients who were classified as recovered at follow-up versus those who did not recover. Six hundred eighteen subjects recruited at baseline could be assessed in the follow-up study. The network structure did not change significantly from baseline to follow-up, and the overall strength of the connections among variables increased slightly, but not significantly. Functional capacity and everyday life skills had a high betweenness and closeness in the network at follow-up, as they had at baseline, while psychopathological variables remained more peripheral. The network structure and connectivity of non-recovered patients were similar to those observed in the whole sample, but very different from those in recovered subjects, in which we found few connections only. These data strongly suggest that tightly coupled symptoms/dysfunctions tend to maintain each other's activation, contributing to poor outcome in schizophrenia. Early and integrated treatment plans, targeting variables with high centrality, might prevent the emergence of self-reinforcing networks of symptoms and dysfunctions in people with schizophrenia.
