نتائج البحث - "Marcus C. S. Lee"

1

Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy

المصدر: Science. 376:1074-1079

مصطلحات موضوعية: Adenosine, Multidisciplinary, Protein Conformation, Plasmodium falciparum, Protozoan Proteins, Crystallography, X-Ray, Antimalarials, Mice, Tyrosine-tRNA Ligase, Protein Biosynthesis, Animals, Humans, Molecular Targeted Therapy, Malaria, Falciparum, Sulfonic Acids

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33885bcc50dbddf18b27ef08501fececTest
https://doi.org/10.1126/science.abn0611Test

2

Lumefantrine attenuates Plasmodium falciparum artemisinin resistance during the early ring stage

المؤلفون: Prapon Wilairat, Maria G. Gomez-Lorenzo, Thanat Chookajorn, Kesinee Chotivanich, Krittikorn Kümpornsin, Laura M. Sanz, Cristina de Cozar, Marcus C. S. Lee, Namfon Kotanan, Duangkamon Loesbanluechai, Nicholas J. White, Francisco-Javier Gamo

المصدر: International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss, Pp 186-190 (2021)
International Journal for Parasitology: Drugs and Drug Resistance

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d3e099e19347efd4515052b596b009Test
http://www.sciencedirect.com/science/article/pii/S2211320721000488Test

3

Barcoding Genetically Distinct Plasmodium falciparum Strains for Comparative Assessment of Fitness and Antimalarial Drug Resistance

المؤلفون: Manuela Carrasquilla, Ndey F. Drammeh, Mukul Rawat, Theo Sanderson, Zenon Zenonos, Julian C. Rayner, Marcus C. S. Lee

المصدر: mBio

مصطلحات موضوعية: Antimalarials, Virology, Plasmodium falciparum, Drug Resistance, Protozoan Proteins, Genetic Fitness, Complex Mixtures, Microbiology, Artemisinins

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a17f81d7c10bd5b1548737cc3556fa7Test
https://doi.org/10.1128/mbio.00937-22Test

4

Efficient generation of mNeonGreen

المؤلفون: Johanna, Hoshizaki, Hannah, Jagoe, Marcus C S, Lee

المصدر: Frontiers in cellular and infection microbiology. 12

مصطلحات موضوعية: Green Fluorescent Proteins, Plasmodium falciparum, Esterases, Protozoan Proteins, Humans, Prodrugs, Malaria, Falciparum

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::d3f03ea034dda768233e77154c51dddbTest
https://pubmed.ncbi.nlm.nih.gov/36189342Test

5

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature communications, vol 11, iss 1

مصطلحات موضوعية: 0301 basic medicine, ved/biology.organism_classification_rank.species, Protozoan Proteins, General Physics and Astronomy, Synthetic lethality, Endoplasmic Reticulum, Plasmodium, Mass Spectrometry, chemistry.chemical_compound, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, Aetiology, lcsh:Science, Chromatography, High Pressure Liquid, Chromatography, Multidisciplinary, Secretory Pathway, biology, Brefeldin A, Cell biology, Infectious Diseases, 5.1 Pharmaceuticals, High Pressure Liquid, HIV/AIDS, Development of treatments and therapeutic interventions, medicine.symptom, Infection, Science, 030106 microbiology, Saccharomyces cerevisiae, Plasmodium falciparum, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Antimalarials, Inhibitory Concentration 50, Rare Diseases, Target identification, parasitic diseases, medicine, Secretion, Model organism, Gene, Secretory pathway, ved/biology, Endoplasmic reticulum, Autophagy, General Chemistry, biology.organism_classification, Malaria, Vector-Borne Diseases, Good Health and Well Being, 030104 developmental biology, chemistry, Mechanism of action, Pyrazoles, lcsh:Q

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b18290350407667761814a3f37b90a3Test
https://doaj.org/article/30325ebc8f1440eb95a7ef787cbdca69Test

6

Scientists on a RAMPAGE to find apicomplexan transcription start sites

المؤلفون: Johanna, Hoshizaki, Marcus C S, Lee

المصدر: Nature reviews. Microbiology. 19(8)

مصطلحات موضوعية: Transcription, Genetic, Sequence Analysis, RNA, Plasmodium falciparum, Protozoan Proteins, Chromosome Mapping, Humans, Malaria, Falciparum, Transcription Initiation Site, Promoter Regions, Genetic, Toxoplasma, Toxoplasmosis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::d1c1584d2e279736f209aa9d041233abTest
https://pubmed.ncbi.nlm.nih.gov/34083794Test

7

Inhibition of resistance-refractory P. falciparum kinase PKG delivers prophylactic, blood stage, and transmission-blocking antiplasmodial activity

المصدر: Cell Chemical Biology

مصطلحات موضوعية: Proteomics, Clinical Biochemistry, Drug Resistance, Protozoan Proteins, Pharmacology, 01 natural sciences, Biochemistry, law.invention, Mice, malaria drug discovery, law, Drug Discovery, Tyrosine, Mice, Inbred BALB C, Gene knockdown, Kinase, Imidazoles, Phosphoproteomics, phosphoproteomics, Molecular Docking Simulation, Recombinant DNA, cardiovascular system, Molecular Medicine, Female, cGMP-dependent protein kinase (PKG), kinase, Plasmodium falciparum, Biology, Article, resistance, Antimalarials, Mediator, target identification, parasitic diseases, Cyclic GMP-Dependent Protein Kinases, Animals, Humans, Metabolomics, Protein kinase A, Molecular Biology, Life Cycle Stages, Binding Sites, conditional knockdown, 010405 organic chemistry, biology.organism_classification, chemoproteomics, 0104 chemical sciences, Hepatocytes

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d625bae4a60074eb3597e6c742453db2Test
https://eprints.gla.ac.uk/216135/1/216135.pdfTest

8

The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites

المصدر: Cell Chem Biol

مصطلحات موضوعية: Hydrolases, Clinical Biochemistry, Plasmodium falciparum, Drug Resistance, Protozoan Proteins, Drug resistance, Biology, 01 natural sciences, Biochemistry, Article, Serine, chemistry.chemical_compound, Antimalarials, parasitic diseases, Drug Discovery, medicine, Animals, Humans, Parasites, Malaria, Falciparum, Diet, Fat-Restricted, Molecular Biology, Pharmacology, Orlistat, Biological Products, Natural product, 010405 organic chemistry, Serine hydrolase, Lipid metabolism, biology.organism_classification, Bridged Bicyclo Compounds, Heterocyclic, Lipid Metabolism, Monoacylglycerol Lipases, Malaria, 0104 chemical sciences, Monoacylglycerol lipase, Mechanism of action, chemistry, Molecular Medicine, Click Chemistry, medicine.symptom

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd1de8040b695e68d20b488036ea2d8Test
https://pubmed.ncbi.nlm.nih.gov/32084335Test

9

Overexpression of plasmepsin II and plasmepsin III does not directly cause reduction in Plasmodium falciparum sensitivity to artesunate, chloroquine and piperaquine

المؤلفون: Megan R. Ansbro, Krittikorn Kümpornsin, Cristina de Cozar, Francisco-Javier Gamo, Kesinee Chotivanich, Thanat Chookajorn, Nicholas J. White, Prapon Wilairat, Laura M. Sanz, Theerarat Kochakarn, Namfon Kotanan, Duangkamon Loesbanluechai, Marcus C. S. Lee

المصدر: International Journal for Parasitology: Drugs and Drug Resistance, Vol 9, Iss, Pp 16-22 (2019)
International Journal for Parasitology: Drugs and Drug Resistance

مصطلحات موضوعية: 0301 basic medicine, 030231 tropical medicine, Population, Plasmodium falciparum, Plasmepsin, Drug Resistance, Gene Dosage, Protozoan Proteins, Artesunate, Microbial Sensitivity Tests, Pharmacology, Biology, Article, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, chemistry.chemical_compound, Antimalarials, Inhibitory Concentration 50, 0302 clinical medicine, Plasmepsin II, Chloroquine, Piperaquine, parasitic diseases, medicine, Aspartic Acid Endopeptidases, Pharmacology (medical), lcsh:RC109-216, Artemisinin, education, education.field_of_study, biology.organism_classification, Malaria, 030104 developmental biology, Infectious Diseases, chemistry, Quinolines, Parasitology, Cambodia, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d17c8d5806e04364f6db892fb8a7b6Test
https://ora.ox.ac.uk/objects/uuid:8b0786fe-9a95-41e1-b755-e01b79b2efb9Test

10

Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13

المؤلفون: Kim C. Heimsch, Gavreel Kalantarov, Marcus C. S. Lee, Sachel Mok, Michal Kuderjavy, Judith Straimer, Barbara H. Stokes, Audrey R. Odom John, Katja Becker, Ilya Trakht, David A. Fidock, Rachel L. Edwards, Nina F. Gnädig, Audrey Crane

المصدر: PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 4, p e1008482 (2020)

مصطلحات موضوعية: Plasmodium, medicine.medical_treatment, Cell Membranes, Mutant, Drug Resistance, Protozoan Proteins, Vacuole, Endoplasmic Reticulum, Biochemistry, Parasite hosting, Biology (General), Malaria, Falciparum, Energy-Producing Organelles, 0303 health sciences, Secretory Pathway, biology, 030302 biochemistry & molecular biology, Artemisinins, Mitochondria, Cell biology, Cell Processes, Cellular Structures and Organelles, Research Article, QH301-705.5, Plasmodium falciparum, Immunology, Dihydroartemisinin, Bioenergetics, Microbiology, Antimalarials, 03 medical and health sciences, Virology, DNA-binding proteins, Parasite Groups, parasitic diseases, Genetics, medicine, Humans, Trophozoites, Hemoglobin, Vesicles, Molecular Biology, 030304 developmental biology, Endoplasmic reticulum, Biology and Life Sciences, Proteins, Membrane Proteins, Cell Biology, RC581-607, biology.organism_classification, Membrane protein, Mutation, Parasitology, Rab, Immunologic diseases. Allergy, Apicomplexa

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043e5f5e56ae46495765fd5c64668dd4Test
https://doi.org/10.1371/journal.ppat.1008482Test

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