المؤلفون: Haocheng Li, Caroline Dutriaux, James Larkin, Edward McKenna, Claus Garbe, Luis de la Cruz-Merino, Athina Voulgari, Mario Mandalà, Paolo A. Ascierto, Lev V. Demidov, Victoria Atkinson, Brigitte Dréno, Antoni Ribas, Michele Maio, Gabriella Liszkay, Surai Jones, Luc Thomas, Jessie Hao-Ru Hsu, Grant A. McArthur, Daniil Stroyakovskiy

المصدر: Clinical Cancer Research. 27:5225-5235

مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Oncology, Cancer Research, medicine.medical_specialty, Skin Neoplasms, Tumor burden, Placebo, chemistry.chemical_compound, Piperidines, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Vemurafenib, Melanoma, Complete response, Advanced melanoma, Cobimetinib, business.industry, Safety profile, chemistry, Mutation, Azetidines, Once daily, business, Follow-Up Studies, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5433fd3a5be3f5bbd73e305a6df55027Test
https://doi.org/10.1158/1078-0432.ccr-21-0809Test

المؤلفون: Reinhard Dummer, Georgina V. Long, Caroline Robert, Hussein A. Tawbi, Keith T. Flaherty, Paolo A. Ascierto, Paul D. Nathan, Piotr Rutkowski, Oleg Leonov, Caroline Dutriaux, Mario Mandalà, Paul Lorigan, Pier Francesco Ferrucci, Jean Jacques Grob, Nicolas Meyer, Helen Gogas, Daniil Stroyakovskiy, Ana Arance, Jan C. Brase, Steven Green, Tomas Haas, Aisha Masood, Eduard Gasal, Antoni Ribas, Dirk Schadendorf

المساهمون: University of Zurich

المصدر: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol 40, iss 13
Dummer, R, Long, G V, Robert, C, Tawbi, H A, Flaherty, K T, Ascierto, P A, Nathan, P D, Rutkowski, P, Leonov, O, Dutriaux, C, Mandalà, M, Lorigan, P, Ferrucci, P F, Grob, J J, Meyer, N, Gogas, H, Stroyakovskiy, D, Arance, A, Brase, J C, Green, S, Haas, T, Masood, A, Gasal, E, Ribas, A & Schadendorf, D 2022, ' Randomized Phase III Trial Evaluating Spartalizumab Plus Dabrafenib and Trametinib for BRAF V600-Mutant Unresectable or Metastatic Melanoma ', Journal of clinical oncology : official journal of the American Society of Clinical Oncology . https://doi.org/10.1200/JCO.21.01601Test

مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Adult, Cancer Research, Skin Neoplasms, Adolescent, Pyridones, Clinical Trials and Supportive Activities, Clinical Sciences, Oncology and Carcinogenesis, Medizin, 610 Medicine & health, Pyrimidinones, Antibodies, Death Domain, Clinical Research, Neoplasms, Oximes, Antineoplastic Combined Chemotherapy Protocols, Receptors, Monoclonal, Genetics, Humans, Oncology & Carcinogenesis, Melanoma, Humanized, Cancer, Manchester Cancer Research Centre, ResearchInstitutes_Networks_Beacons/mcrc, Human Genome, Imidazoles, Evaluation of treatments and therapeutic interventions, 10177 Dermatology Clinic, Second Primary, Oncology, 6.1 Pharmaceuticals, Mutation

وصف الملف: 928_Dummer_R._et_al._Randomized_Phase_III_Trial_Evaluationg_Spartalizumab_plus_Dabrafenib_and_Trametinib_for_BRAF_V600_mutant_JCO_2022.pdf - application/pdf; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512e67c5f66bacf61087d7e838e0dc59Test
https://www.zora.uzh.ch/id/eprint/213526Test/

المؤلفون: Ralf, Gutzmer, Daniil, Stroyakovskiy, Helen, Gogas, Caroline, Robert, Karl, Lewis, Svetlana, Protsenko, Rodrigo P, Pereira, Thomas, Eigentler, Piotr, Rutkowski, Lev, Demidov, Georgy Moiseevich, Manikhas, Yibing, Yan, Kuan-Chieh, Huang, Anne, Uyei, Virginia, McNally, Grant A, McArthur, Paolo A, Ascierto

المصدر: Lancet (London, England). 395(10240)

مصطلحات موضوعية: Adult, Male, Proto-Oncogene Proteins B-raf, Kaplan-Meier Estimate, Middle Aged, Antibodies, Monoclonal, Humanized, Drug Administration Schedule, Progression-Free Survival, Double-Blind Method, Piperidines, Vemurafenib, Antineoplastic Combined Chemotherapy Protocols, Mutation, Azetidines, Humans, Female, Neoplasm Metastasis, Melanoma, Aged, Neoplasm Staging

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::ae0fc6f1503f4e8640866ea2c3ddd337Test
https://pubmed.ncbi.nlm.nih.gov/32798490Test

المؤلفون: Reinhard Dummer, Bijoyesh Mookerjee, Mayur M. Amonkar, Andrzej Mackiewicz, Diane Opatt McDowell, Peng Sun, Jean-Jacques Grob, Keith T. Flaherty, Antoni Ribas, Evgeny Levchenko, Florent Grange, Paul Nathan, Piotr Rutkowski, Mikhail Lichinitser, Axel Hauschild, Georgina V. Long, Dirk Schadendorf, Jeffrey J. Legos, Vanna Chiarion-Sileni, Pascal Wolter, Kamil Drucis, Caroline Robert, Daniil Stroyakovskiy, Boguslawa Karaszewska, Jacob Schachter

المساهمون: University of Zurich, Grob, Jean Jacques

المصدر: The Lancet Oncology. 16:1389-1398

مصطلحات موضوعية: Oncology, Indoles, Skin Neoplasms, Time Factors, DNA Mutational Analysis, Medizin, Administration, Oral, law.invention, Randomized controlled trial, Risk Factors, law, Surveys and Questionnaires, Antineoplastic Combined Chemotherapy Protocols, Oximes, Clinical endpoint, Prospective Studies, Vemurafenib, Melanoma, Trametinib, Sulfonamides, education.field_of_study, Imidazoles, 10177 Dermatology Clinic, MAP Kinase Kinase Kinases, Intention to Treat Analysis, Phenotype, Treatment Outcome, Disease Progression, 2730 Oncology, medicine.drug, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Combination therapy, Pyridones, Population, 610 Medicine & health, Pyrimidinones, Disease-Free Survival, Drug Administration Schedule, Internal medicine, Biomarkers, Tumor, medicine, Humans, Genetic Predisposition to Disease, education, Protein Kinase Inhibitors, business.industry, Dabrafenib, medicine.disease, Surgery, Mutation, Quality of Life, business

وصف الملف: 634_Grob JJ_Comparison of dabrafenib and trametinib combination therapy with vemurafenib_Lancet Oncology 2015.pdf - application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba5b05e303e47c6db30c556a47fdfbbTest
https://doi.org/10.1016/s1470-2045Test(15)00087-x

المؤلفون: Karen Bartley, Ilsung Chang, Grant A. McArthur, Victoria Atkinson, Antoni Ribas, Caroline Dutriaux, Gabriella Liszkay, Mario Mandalà, Luc Thomas, Daniel O. Koralek, Claus Garbe, Daniil Stroyakovskiy, Lev V. Demidov, Paolo A. Ascierto, Isabelle Rooney, Michele Maio, Brigitte Dréno, Thomas Karagiannis, James Larkin, Luis de la Cruz-Merino

المصدر: Dreno, B; Ascierto, PA; Atkinson, V; Liszkay, G; Maio, M; Mandala, M; et al.(2018). Health-related quality of life impact of cobimetinib in combination with vemurafenib in patients with advanced or metastatic BRAF(V600) mutation-positive melanoma. BRITISH JOURNAL OF CANCER, 118(6), 777-784. doi: 10.1038/bjc.2017.488. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6wh1k688Test
British journal of cancer, vol 118, iss 6
British Journal of Cancer

مصطلحات موضوعية: 0301 basic medicine, Oncology, Male, Cancer Research, law.invention, Placebos, chemistry.chemical_compound, 0302 clinical medicine, Quality of life, Randomized controlled trial, Piperidines, law, Antineoplastic Combined Chemotherapy Protocols, Longitudinal Studies, Vemurafenib, cobimetinib, Melanoma, education.field_of_study, Rash, humanities, HRQOL, 030220 oncology & carcinogenesis, Public Health and Health Services, BRAF inhibitor, Cobimetinib, EORTC QLQ-C30, MEK inhibitor, Metastatic melanoma, Azetidines, Double-Blind Method, Female, Humans, Proto-Oncogene Proteins B-raf, Quality of Life, Mutation, vemurafenib, medicine.symptom, medicine.drug, metastatic melanoma, medicine.medical_specialty, Population, Oncology and Carcinogenesis, Placebo, 03 medical and health sciences, Internal medicine, medicine, Oncology & Carcinogenesis, education, business.industry, medicine.disease, 030104 developmental biology, chemistry, Clinical Study, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d78bd78edaae6919cb2c2a09ab9ea438Test
http://www.escholarship.org/uc/item/6wh1k688Test

المؤلفون: Bijoyesh Mookerjee, Michael Millward, J.-J. Grob, Paul Nathan, Céleste Lebbé, Johan Hansson, Daniil Stroyakovskiy, J.B.A.G. Haanen, Peter Mohr, Igor Bondarenko, Stephen R. Lane, Jochen Utikal, Vanna Chiarion-Sileni, Ana Arance, Evgeny Levchenko, Michael A. Davies, V. Probachai, Virginia Ferraresi, Keith T. Flaherty, Antoni Ribas, James Larkin, Caroline Robert, Axel Hauschild, F. de Braud, Thomas Jouary, Mario Mandalà, Jeffrey J. Legos, Dirk Schadendorf, Helen Gogas, Georgina V. Long, Claus Garbe

المصدر: Annals of oncology : official journal of the European Society for Medical Oncology, vol 28, iss 7
Annals of Oncology

مصطلحات موضوعية: 0301 basic medicine, Oncology, Skin Neoplasms, Time Factors, Medizin, Phases of clinical research, Kaplan-Meier Estimate, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, Oximes, Antineoplastic Combined Chemotherapy Protocols, Clinical endpoint, Melanoma, Cancer, Trametinib, 0303 health sciences, Tumor, trametinib, Imidazoles, Binimetinib, Hematology, Corrigenda, 3. Good health, metastatic, Treatment Outcome, 030220 oncology & carcinogenesis, durable outcomes, 6.1 Pharmaceuticals, Disease Progression, medicine.drug, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Combination therapy, Pyridones, Clinical Trials and Supportive Activities, Oncology and Carcinogenesis, Pyrimidinones, Disease-Free Survival, Drug Administration Schedule, BRAF, 03 medical and health sciences, Double-Blind Method, Clinical Research, Internal medicine, Biomarkers, Tumor, medicine, melanoma, Humans, Progression-free survival, Oncology & Carcinogenesis, dabrafenib, Protein Kinase Inhibitors, 030304 developmental biology, business.industry, Evaluation of treatments and therapeutic interventions, Dabrafenib, Original Articles, medicine.disease, Surgery, 030104 developmental biology, chemistry, Mutation, business, Biomarkers

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21294d19c21bbb3aa078909c1dc2780Test
https://escholarship.org/uc/item/2cw0m84kTest

المؤلفون: Antoni Ribas, Brigitte Dréno, Anna Maria Di Giacomo, Victoria Atkinson, Mario Mandalà, Claus Garbe, Luc Thomas, Grant A. McArthur, James Larkin, Luis de la Cruz-Merino, Paolo A. Ascierto, Daniil Stroyakovskiy, Isabelle Rooney, Jessie J. Hsu, Caroline Dutriaux, Lev V. Demidov, Matthew Wongchenko, Daniel O. Koralek, Ilsung Chang, G. Liszkay, Yibing Yan

مصطلحات موضوعية: 0301 basic medicine, Oncology, Male, Indoles, Skin Neoplasms, law.invention, chemistry.chemical_compound, 0302 clinical medicine, Randomized controlled trial, Piperidines, law, Antineoplastic Combined Chemotherapy Protocols, Neoplasm Metastasis, Vemurafenib, Melanoma, Aged, 80 and over, education.field_of_study, Sulfonamides, Tumor, Middle Aged, Prognosis, Survival Rate, 030220 oncology & carcinogenesis, Female, medicine.drug, Adult, Proto-Oncogene Proteins B-raf, Survival Rate [MeSH], medicine.medical_specialty, Population, Placebo, 03 medical and health sciences, Young Adult, Double-Blind Method, Internal medicine, medicine, Biomarkers, Tumor, Humans, education, Survival rate, Aged, Neoplasm Staging, Cobimetinib, business.industry, medicine.disease, Surgery, Clinical trial, 030104 developmental biology, chemistry, Azetidines, Mutation, business, Biomarkers, Follow-Up Studies

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace978176cf5d18d1e720f399aec8567Test
https://hdl.handle.net/11365/1233346Test

المؤلفون: Michelle Casey, Caroline Robert, Claus Garbe, Filippo de Braud, Daniil Stroyakovskiy, Gursel Aktan, Igor Bondarenko, Vanna Chiarion-Sileni, Ana Arance, Jean-Jacques Grob, Michael Millward, Paul Nathan, Jhangir G. Irani, Helen Gogas, Keith T. Flaherty, James Larkin, Douglas J. DeMarini, Mario Mandalà, Dirk Schadendorf, Antoni Ribas, Céleste Lebbé, Georgina V. Long, Mayur M. Amonkar, Evgeny Levchenko

المصدر: European journal of cancer (Oxford, England : 1990). 51(7)

مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Cancer Research, medicine.medical_specialty, Constipation, Skin Neoplasms, Nausea, Pyridones, Health Status, Medizin, Pyrimidinones, Proto-Oncogene Mas, Quality of life, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Oximes, Medicine, Humans, Neoplasm Metastasis, Melanoma, Pain Measurement, Trametinib, business.industry, Imidazoles, Cancer, Dabrafenib, Valine, medicine.disease, Oncology, Amino Acid Substitution, Vomiting, Physical therapy, Quality of Life, medicine.symptom, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b244161965b517ec788a1d14c803db9eTest
https://pubmed.ncbi.nlm.nih.gov/25794603Test

المؤلفون: Daniil Stroyakovskiy, Peter Mohr, Virginia Ferraresi, Michael Millward, Paul Nathan, Claus Garbe, Filippo de Braud, Caroline Robert, Jhangir G. Irani, Igor Bondarenko, Vanna Chiarion-Sileni, Jochen Utikal, Nadezhda Kovalenko, Douglas J Demarini, Bijoyesh Mookerjee, James Larkin, Ana Arance, Suzanne Swann, Mario Mandalà, Axel Hauschild, Jeffrey J. Legos, John B. A. G. Haanen, Jean-Jacques Grob, Keith T. Flaherty, Antoni Ribas, Johan Hansson, Dirk Schadendorf, Georgina V. Long, Thomas Jouary, Helen Gogas, Fan Jin, Volodymr Probachai, Céleste Lebbé, Evgeny Levchenko

مصطلحات موضوعية: Adult, Male, Proto-Oncogene Proteins B-raf, Oncology, medicine.medical_specialty, Pyridones, Medizin, Phases of clinical research, Pyrimidinones, Placebo, Disease-Free Survival, Young Adult, chemistry.chemical_compound, Double-Blind Method, Internal medicine, Oximes, medicine, Clinical endpoint, Humans, Melanoma, Aged, Aged, 80 and over, Trametinib, Cobimetinib, business.industry, Hazard ratio, Imidazoles, Dabrafenib, General Medicine, Middle Aged, medicine.disease, Surgery, Treatment Outcome, chemistry, Drug Therapy, Combination, Female, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7305a840ef7860ce6dbedc881e5fe7cfTest
http://hdl.handle.net/11391/1480871Test

المؤلفون: Stephen P. Hack, James Larkin, Luis de la Cruz-Merino, Grant A. McArthur, Luc Thomas, Nicholas Choong, Claus Garbe, Gabriella Liszkay, Victoria Atkinson, Daniil Stroyakovskiy, Ilsung Chang, Lev V. Demidov, Mario Mandalà, Caroline Dutriaux, Brigitte Dréno, Antoni Ribas, Mika A. Sovak, Paolo A. Ascierto, Michele Maio

المساهمون: [Larkin,J] Royal Marsden Hospital, London.[Ascierto,PA] Istituto Nazionale Tumori Fondazione G. Pascale, Naples,Italy. [Dréno,B] Hôtel Dieu Place Alexis Ricordeau,Nantes,France. [Atkinson,V] Princess Alexandra Hospital, Woolloongabba, QLD,Australia. [Liszkay,G] National Institute of Oncology, Budapest, Hungary. [Maio,M] Azienda Ospedaliera Universitaria Senese, Siena,Italy. [Mandalà,M] Papa Giovanni XXIII Hospital, Bergamo,Italy. [Demidov,L] Blokhin Russian Cancer Research Center, Moscow,Russia. [Stroyakovskiy,D] Moscow City Oncology Hospital 62, Krasnogorsk, Russia. [Thomas,L] Centre Hospitalier Lyon Sud, Pierre-Bénite,France. [de la Cruz-Merino,L] Hospital Universitario Virgen Macarena, Seville, Spain. [Dutriaux,C] Hôpital Saint André, Bordeaux,France. [Garbe,C] University of Tübingen, Tübingen, Germany. [Sovak,MA, Chang,I, Choong,N, Hack,SP] Genentech, South San Francisco.[Ribas,A] Jonsson Comprehensive Cancer Center at the University of California, Los Angeles., Supported by F. Hoffmann–La Roche/Genentech.

مصطلحات موضوعية: Oncology, medicine.medical_specialty, Indoles, Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation [Medical Subject Headings], Information Science::Information Science::Data Collection::Vital Statistics::Mortality::Survival Rate [Medical Subject Headings], Azetidinas, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases::Mitogen-Activated Protein Kinase Kinases::MAP Kinase Kinase 1 [Medical Subject Headings], Check Tags::Male [Medical Subject Headings], Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], chemistry.chemical_compound, Internal medicine, medicine, Piperidinas, Named Groups::Persons::Age Groups::Adult [Medical Subject Headings], Named Groups::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Vemurafenib, Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Indoles [Medical Subject Headings], Survival rate, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Disease-Free Survival [Medical Subject Headings], Diseases::Neoplasms::Neoplasms by Histologic Type::Nevi and Melanomas::Melanoma [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Clinical Protocols::Antineoplastic Protocols::Antineoplastic Combined Chemotherapy Protocols [Medical Subject Headings], Cobimetinib, Trametinib, Sulfonamides, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Survival Analysis::Kaplan-Meier Estimate [Medical Subject Headings], business.industry, MEK inhibitor, Melanoma, Sulfonamidas, Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Azetines::Azetidines [Medical Subject Headings], Binimetinib, Dabrafenib, General Medicine, medicine.disease, Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Piperidines [Medical Subject Headings], Surgery, Chemicals and Drugs::Organic Chemicals::Sulfur Compounds::Sulfones::Sulfonamides [Medical Subject Headings], MAP quinasa quinasa 1, chemistry, Check Tags::Female [Medical Subject Headings], Proto-oncogene proteins B-raf, Azetidines, business, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm Proteins::Oncogene Proteins::Proto-Oncogene Proteins::raf Kinases::Proto-Oncogene Proteins B-raf [Medical Subject Headings], medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058bae456f14e0981fcd75b5620ef91eTest
https://hdl.handle.net/10668/2159Test