التفاصيل البيبلوغرافية
| العنوان: |
Prognostic significance of CD45RO+ memory T cells in renal cell carcinoma. |
| المؤلفون: |
Hotta, K, Sho, M, Fujimoto, K, Shimada, K, Yamato, I, Anai, S, Konishi, N, Hirao, Y, Nonomura, K, Nakajima, Y |
| المصدر: |
British Journal of Cancer; 10/11/2011, Vol. 105 Issue 8, p1191-1196, 6p, 1 Black and White Photograph, 3 Charts, 2 Graphs |
| مصطلحات موضوعية: |
T cells, IMMUNOHISTOCHEMISTRY, RENAL cell carcinoma, LYMPHOCYTES, PROTEIN-tyrosine phosphatase, LEUCOCYTES |
| مستخلص: |
Background: Memory T cells are well known to have a critical role for host defense in humans. However, their role in actual human cancer remains largely unknown. In this study, we tried to reveal the clinical importance of tumour-infiltrating CD45RO+ memory T cells in renal cell carcinoma (RCC).Methods: We analysed 105 patients with RCC, who received radical or partial nephrectomy. Those were 65 in TNM stage I, 7 in stage II, 15 in stage III, and 18 in stage IV, respectively. CD45RO expression was evaluated by immunohistochemistry. CD4 and CD8 expressions were also systematically assessed in the same manner.Results: Patients with higher TNM stage or high nuclear grade were found to have higher densities of CD45RO. Furthermore, CD45RO status was positively correlated with preoperative C-reactive protein level. In prognostic analysis, CD45RO+lo patients had a significantly better prognosis than CD45RO+hi patients. There was also a significant difference between CD4+lo and CD4+hi groups, whereas no significant difference was observed in CD8 T-cell status. Finally, multivariate analysis revealed that CD45RO+ status was the independent prognostic factor for patient overall survival.Conclusion: CD45RO+ memory T-cell status has a significant independent prognostic value, indicating that the adaptive immune response is functionally critical in human RCC. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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