نتائج البحث - "stapled peptides"

المصدر: Bluntzer, M T J, O'Connell, J, Baker, T S, Michel, J & Hulme, A N 2020, ' Designing stapled peptides to inhibit protein-protein interactions: An analysis of successes in a rapidly changing field ', Peptide Science . https://doi.org/10.1002/pep2.24191Test

مصطلحات موضوعية: crystal structure, Field (physics), analysis, Chemistry, design, Organic Chemistry, Biophysics, stapled peptides, Biochemistry, Protein–protein interaction, Biomaterials, therapeutics

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a726d6b19d1a47889d1163cb28a98bTest
https://doi.org/10.1002/pep2.24191Test

5

Stapled Peptides as HIF-1α/p300 Inhibitors: Helicity Enhancement in the Bound State Increases Inhibitory Potency

المؤلفون: Kristina Hetherington, Thomas A. Edwards, Adam Nelson, Richard B. Sessions, Zsófia Hegedüs, Andrew J. Wilson

المصدر: Chemistry (Weinheim an Der Bergstrasse, Germany)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde68abcd87b8fa6bb5ab0145ae7c8e5Test
https://pubmed.ncbi.nlm.nih.gov/32307728Test

6

Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design

المؤلفون: Aline C. Simon, Luca Pellegrini, Karim Labib, Lina Dobnikar, Yuteng Wu, Joseph D. Maman, David R. Spring, Fabrizio Villa, Yu Heng Lau

المساهمون: Pellegrini, Luca [0000-0002-9300-497X], Apollo - University of Cambridge Repository

المصدر: Angewandte Chemie International Edition. 56:12866-12872

مصطلحات موضوعية: 0301 basic medicine, Saccharomyces cerevisiae Proteins, DNA polymerase, Amino Acid Motifs, protein-protein interactions, Chemical biology, chemical biology, Fluorescence Polarization, Peptide, Saccharomyces cerevisiae, Synthetic lethality, Computational biology, stapled peptides, Molecular Dynamics Simulation, 010402 general chemistry, Crystallography, X-Ray, 01 natural sciences, Genomic Instability, Catalysis, Protein–protein interaction, 03 medical and health sciences, Humans, Protein Interaction Domains and Motifs, Ctf4 protein, chemistry.chemical_classification, Binding Sites, biology, Chemistry, DNA replication, Helicase, General Medicine, Diazonium Compounds, General Chemistry, DNA Polymerase I, 0104 chemical sciences, Protein Structure, Tertiary, DNA-Binding Proteins, chromosome stability, 030104 developmental biology, Biochemistry, biology.protein, Replisome, Peptides

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d074b026e320423d4280ee9756ef1fTest
https://doi.org/10.1002/anie.201705611Test

7

Recognition of ASF1 by Using Hydrocarbon-Constrained Peptides

المؤلفون: Marie E. Perrin, May Bakail, Silvia Rodriguez-Marin, Andrew J. Wilson, Zsófia Hegedüs, Françoise Ochsenbein

المساهمون: Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Assemblage moléculaire et intégrité du génome (AMIG), Département Biochimie, Biophysique et Biologie Structurale (B3S), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)

المصدر: ChemBioChem
ChemBioChem, 2019, 20 (7), pp.891--895. ⟨10.1002/cbic.201800633⟩
Chembiochem

مصطلحات موضوعية: replication, helix, Stereochemistry, Protein Conformation, [SDV]Life Sciences [q-bio], Chemical biology, protein-protein interactions, Cell Cycle Proteins, chemical biology, protein–protein interactions, Alkenes, stapled peptides, 010402 general chemistry, 01 natural sciences, Biochemistry, Protein–protein interaction, Histones, Histone H3, protein-protein interactions histone chaperonnes constrained peptides protein surface recognition chemical biology, protein surface recognition, Humans, modulators, Amino Acid Sequence, Molecular Biology, biology, 010405 organic chemistry, Chemistry, Communication, Organic Chemistry, histone chaperones, structural basis, constrained peptides, Peptide Fragments, Communications, 0104 chemical sciences, Constraint (information theory), Histone, Glycine, Helix, biology.protein, Molecular Medicine, Thermodynamics, Function (biology), complex, Molecular Chaperones, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dabb754ab60b9fd3e903a164aac28f18Test
https://hal.archives-ouvertes.fr/hal-02169570Test

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Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases

المؤلفون: Sarah Ross, Jefferson D. Revell, Darerca Owen, Catherine A. Hurd, Paul Brear, Helen R. Mott

المساهمون: Brear, Paul [0000-0002-4045-0474], Mott, Helen [0000-0002-7890-7097], Owen, Darerca [0000-0003-0978-5425], Apollo - University of Cambridge Repository

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, GMPPNP, guanosine 5'-[β,γ-imido] triphosphate, Magnetic Resonance Spectroscopy, GTPase, stapled peptides, DMF, N,N-dimethylformamide, Biochemistry, protein-protein interaction, SPA, scintillation proximity assay, RBD, Ral binding domain, CD, circular dichroism, RLIP76, RALB, ITC, isothermal titration calorimetry, Chemistry, Circular Dichroism, GTPase-Activating Proteins, Cell biology, FP, fluorescence polarization, Guanine nucleotide exchange factor, K-Ras, Fmoc, 9-fluorenylmethoxycarbonyl, Protein Binding, Signal Transduction, Research Article, Binding domain, animal structures, PPI, protein–protein interaction, Chemical biology, chemical biology, Calorimetry, Fluorescence, drug discovery, Protein–protein interaction, GEF, guanine nucleotide exchange factor, TFA, trifluoroacetic acid, Affinity maturation, 03 medical and health sciences, FAM, carboxyfluorescein, Humans, cancer, cell signaling, Molecular Biology, GGTase, geranylgeranyltransferase, 030102 biochemistry & molecular biology, CPP, cell-penetrating peptide, Cell Biology, Ral, 030104 developmental biology, GAP, GTPase activating protein, Cell-penetrating peptide, ATP-Binding Cassette Transporters, ral GTP-Binding Proteins