المؤلفون: Samadi, Ak, Bilsland, A, Georgakilas, Ag, Amedei, A, Amin, A, Bishayee, A, Azmi, As, Lokeshwar, Bl, Grue, B, Panis, C, Boosani, Cs, Poudyal, D, Stafforini, Dm, Bhakta, D, Niccolai, E, Guha, G, Vasantha Rupasinghe, Hp, Fujii, H, Honoki, K, Mehta, K, Aquilano, K, Lowe, L, Hofseth, Lj, Ciriolo, Mr, Singh, N, Whelan, Rl, Chaturvedi, R, Ashraf, Ss, Shantha Kumara, Hm, Nowsheen, S, Mohammed, Si, Keith, Wn, Helferich, Wg, Yang, X.2.8., RICCIARDIELLO, LUIGI

المساهمون: Samadi, Ak, Bilsland, A, Georgakilas, Ag, Amedei, A, Amin, A, Bishayee, A, Azmi, A, Lokeshwar, Bl, Grue, B, Panis, C, Boosani, C, Poudyal, D, Stafforini, Dm, Bhakta, D, Niccolai, E, Guha, G, Vasantha Rupasinghe, Hp, Fujii, H, Honoki, K, Mehta, K, Aquilano, K, Lowe, L, Hofseth, Lj, Ricciardiello, L, Ciriolo, Mr, Singh, N, Whelan, Rl, Chaturvedi, R, Ashraf, S, Shantha Kumara, Hm, Nowsheen, S, Mohammed, Si, Keith, Wn, Helferich, Wg, Yang, X28.

مصطلحات موضوعية: Cancers harbor significant genetic heterogeneity and patterns of relapse following many therapies are due to evolved resistance to treatment. While efforts have been made to combine targeted therapies, significant levels of toxicity have stymied efforts to effectively treat cancer with multi-drug combinations using currently approved therapeutics. We discuss the relationship between tumor-promoting inflammation and cancer as part of a larger effort to develop a broad-spectrum therapeutic approach aimed at a wide range of targets to address this heterogeneity. Specifically, macrophage migration inhibitory factor, cyclooxygenase-2, transcription factor nuclear factor-κB, tumor necrosis factor alpha, inducible nitric oxide synthase, protein kinase B, and CXC chemokines are reviewed as important antiinflammatory targets while curcumin, resveratrol, epigallocatechin gallate, genistein, lycopene, and anthocyanins are reviewed as low-cost, low toxicity means by which these targets might all be reached simultaneously. Future translational work will need to assess the resulting synergies of rationally designed antiinflammatory mixtures (employing low-toxicity constituents), and then combine this with similar approaches targeting the most important pathways across the range of cancer hallmark phenotypes, stat, envir

العلاقة: http://hdl.handle.net/11585/490971Test

الإتاحة: http://hdl.handle.net/11585/490971Test

المؤلفون: Anupam Bishayee, Kapil Mehta, Leroy Lowe, Somaira Nowsheen, S. Salman Ashraf, Luigi Ricciardiello, Kanya Honoki, Alan Bilsland, Deepak Poudyal, Rupesh Chaturvedi, Elena Niccolai, Amedeo Amedei, Hiromasa Fujii, Lorne J. Hofseth, Maria Rosa Ciriolo, Amr Amin, Katia Aquilano, Brendan Grue, Neetu Singh, Dipita Bhakta, Xujuan Yang, Chandra S. Boosani, Asfar S. Azmi, Richard L. Whelan, Carolina Panis, Abbas Samadi, Alexandros G. Georgakilas, Sulma I. Mohammed, H. M. C. Shantha Kumara, William G. Helferich, Diana M. Stafforini, W. Nicol Keith, Gunjan Guha, Balakrishna L. Lokeshwar, H.P. Vasantha Rupasinghe

المساهمون: Samadi, Ak, Bilsland, A, Georgakilas, Ag, Amedei, A, Amin, A, Bishayee, A, Azmi, A, Lokeshwar, Bl, Grue, B, Panis, C, Boosani, C, Poudyal, D, Stafforini, Dm, Bhakta, D, Niccolai, E, Guha, G, Vasantha Rupasinghe, Hp, Fujii, H, Honoki, K, Mehta, K, Aquilano, K, Lowe, L, Hofseth, Lj, Ricciardiello, L, Ciriolo, Mr, Singh, N, Whelan, Rl, Chaturvedi, R, Ashraf, S, Shantha Kumara, Hm, Nowsheen, S, Mohammed, Si, Keith, Wn, Helferich, Wg, Yang, X28.

مصطلحات موضوعية: Cancer Research, Cancer, Hallmarks, Inflammation, Phytochemicals, Tumor, Antineoplastic Agents, Resveratrol, Pharmacology, Biology, Article, chemistry.chemical_compound, Genetic Heterogeneity, Neoplasms, medicine, Humans, Molecular Targeted Therapy, Settore BIO/10, Transcription factor, Protein kinase B, Cancers harbor significant genetic heterogeneity and patterns of relapse following many therapies are due to evolved resistance to treatment. While efforts have been made to combine targeted therapies, significant levels of toxicity have stymied efforts to effectively treat cancer with multi-drug combinations using currently approved therapeutics. We discuss the relationship between tumor-promoting inflammation and cancer as part of a larger effort to develop a broad-spectrum therapeutic approach aimed at a wide range of targets to address this heterogeneity. Specifically, macrophage migration inhibitory factor, cyclooxygenase-2, transcription factor nuclear factor-κB, tumor necrosis factor alpha, inducible nitric oxide synthase, protein kinase B, and CXC chemokines are reviewed as important antiinflammatory targets while curcumin, resveratrol, epigallocatechin gallate, genistein, lycopene, and anthocyanins are reviewed as low-cost, low toxicity means by which these targets might all be reached simultaneously. Future translational work will need to assess the resulting synergies of rationally designed antiinflammatory mixtures (employing low-toxicity constituents), and then combine this with similar approaches targeting the most important pathways across the range of cancer hallmark phenotypes, medicine.disease, 3. Good health, Neoplasm Proteins, Cell Transformation, Neoplastic, chemistry, Cancer research, Tumor necrosis factor alpha, Macrophage migration inhibitory factor, Signal transduction, medicine.symptom, Signal Transduction

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4907fb267ccb7715643f50065fac26f1Test
https://eprints.gla.ac.uk/114287/1/114287.pdfTest