المؤلفون: Annette N. Chiang, Disha Joshi, Peter Wipf, Mads B. Larsen, Raymond A. Frizzell, Jeffrey L. Brodsky, Clare Hill, Jennifer L. Goeckeler-Fried, Rajiah Aldrin Denny, Eric J. Sorscher

المصدر: Bioorg Med Chem Lett

مصطلحات موضوعية: Protein Folding, Ubiquitin-activating enzyme, Clinical Biochemistry, Pharmaceutical Science, Cystic Fibrosis Transmembrane Conductance Regulator, Endoplasmic-reticulum-associated protein degradation, Protein degradation, Biochemistry, Benzoates, Article, Structure-Activity Relationship, Ubiquitin, Drug Discovery, Humans, Furans, Molecular Biology, Integral membrane protein, biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Ubiquitination, Cystic fibrosis transmembrane conductance regulator, Protein ubiquitination, Cell biology, biology.protein, Molecular Medicine, Pyrazoles, Protein folding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9acacfc386f55a26c851fd71b6ecd340Test
https://pubmed.ncbi.nlm.nih.gov/34246753Test

المؤلفون: Carly S. Mazzone, Antonio Dominguez-Meijide, Jeffrey L. Brodsky, Mary Liang, Tiago F. Outeiro, Annette N. Chiang, David Newhouse, Peter Wipf, Nathan M. Kendsersky, Megan E. Yates, Patrick G. Needham, Caterina Masaracchia, Alexandra Manos-Turvey, Jennifer L. Goeckeler-Fried

المصدر: Bioorganic & Medicinal Chemistry. 27:79-91

مصطلحات موضوعية: Protein Folding, Clinical Biochemistry, Mutant, Cystic Fibrosis Transmembrane Conductance Regulator, Enzyme Activators, Pharmaceutical Science, Pyrimidinones, Saccharomyces cerevisiae, Protein aggregation, 01 natural sciences, Biochemistry, Article, Structure-Activity Relationship, Cell Line, Tumor, Cellular stress response, Drug Discovery, Humans, HSP70 Heat-Shock Proteins, Molecular Biology, Adenosine Triphosphatases, Molecular Structure, biology, 010405 organic chemistry, Activator (genetics), Chemistry, Organic Chemistry, HEK 293 cells, Esters, Cystic fibrosis transmembrane conductance regulator, 3. Good health, 0104 chemical sciences, Hsp70, Cell biology, 010404 medicinal & biomolecular chemistry, HEK293 Cells, Proteostasis, alpha-Synuclein, biology.protein, Molecular Medicine, Protein Multimerization

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e5c63d4a71c5b638613d360a3ee103Test
https://doi.org/10.1016/j.bmc.2018.11.011Test

المؤلفون: W. Joon Chung, Adam B. Keeton, Allan M. Weissman, Zackery E. Plyler, E. Lucile White, Jeffrey L. Brodsky, Marina Mazur, Viktória Havasi, Eric J. Sorscher, Lynn Rasmussen, Gary A. Piazza, Jennifer L. Goeckeler-Fried, Jeong S. Hong, Annette N. Chiang, R. Aldrin Denny, Steven M. Rowe

المصدر: PLoS ONE, Vol 11, Iss 10, p e0163615 (2016)
PLoS ONE

مصطلحات موضوعية: 0301 basic medicine, Protein Folding, Cystic Fibrosis, Pulmonology, Cell Membranes, Cystic Fibrosis Transmembrane Conductance Regulator, lcsh:Medicine, Bioinformatics, Endoplasmic Reticulum, Hydroxamic Acids, Cystic fibrosis, Benzoates, Biochemistry, Epithelium, Mutant protein, Animal Cells, Medicine and Health Sciences, lcsh:Science, Cells, Cultured, Vorinostat, Multidisciplinary, biology, Organic Compounds, Messenger RNA, Small molecule, Cystic fibrosis transmembrane conductance regulator, 3. Good health, Cell biology, Nucleic acids, Chemistry, Genetic Diseases, High-content screening, Physical Sciences, Cell lines, Cellular Types, Anatomy, Cellular Structures and Organelles, Biological cultures, Research Article, Biotechnology, Library Screening, Research and Analysis Methods, Small Molecule Libraries, 03 medical and health sciences, Autosomal Recessive Diseases, medicine, Humans, RNA, Messenger, Furans, Molecular Biology Techniques, Molecular Biology, Alleles, Clinical Genetics, Molecular Biology Assays and Analysis Techniques, Endoplasmic reticulum, Organic Chemistry, HEK 293 cells, lcsh:R, Wild type, Ubiquitination, Chemical Compounds, Biology and Life Sciences, Epithelial Cells, Cell Biology, Cell Cultures, medicine.disease, Fibrosis, High-Throughput Screening Assays, Protein Structure, Tertiary, 030104 developmental biology, HEK293 Cells, Biological Tissue, Microscopy, Fluorescence, Small Molecules, biology.protein, Pyrazoles, RNA, lcsh:Q, Gene Deletion, HeLa Cells, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::548cb6f2b3cb88d56f75f466b19a5a57Test
http://europepmc.org/articles/PMC5061379?pdf=renderTest