المؤلفون: Justin L. Anglin, Kevin Riehle, John C. Faver, Marta Storl-Desmond, Rajesh Sharma, Damian W. Young, Melek N. Ucisik, Gundeep Kaur, Feng Li, Choel Kim, Kiran L. Sharma, Nicholas Simmons, Zhifeng Yu, Sureshbabu Nagarajan, Martin M. Matzuk, Pranavanand Nyshadham, Stephen Palmer, Banumathi Sankaran, Angela F. Ku

المصدر: Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 9
Proceedings of the National Academy of Sciences of the United States of America

مصطلحات موضوعية: Protein Conformation, alpha-Helical, Male, Subfamily, Protein Conformation, Gene Expression, Quantitative Structure-Activity Relationship, Cell Cycle Proteins, Crystallography, X-Ray, Ligands, 01 natural sciences, Biochemistry, Mice, Testis, Drug Discovery, Cloning, Molecular, Cancer, 0303 health sciences, Multidisciplinary, Crystallography, Chemistry, Nuclear Proteins, Azepines, Biological Sciences, Small molecule, Recombinant Proteins, Molecular Docking Simulation, small-molecule inhibitors, Knockout mouse, Protein Binding, BRD4, Genetic Vectors, 03 medical and health sciences, DNA-encoded chemistry, Contraceptive Agents, In vivo, Escherichia coli, Genetics, Potency, Animals, Humans, Protein Interaction Domains and Motifs, 030304 developmental biology, BET bromodomains, Binding Sites, 010405 organic chemistry, Contraception/Reproduction, alpha-Helical, Contraceptive Agents, Male, Molecular, Triazoles, In vitro, 0104 chemical sciences, Bromodomain, High-Throughput Screening Assays, male contraceptive, X-Ray, Protein Conformation, beta-Strand, beta-Strand, Transcription Factors, Cloning

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a47b29b36c4d8ecbdaff9fff6156c7cTest
https://escholarship.org/uc/item/9t49g9frTest

المؤلفون: Robin Lorenz, Albert S. Reger, Jeong Joo Kim, Darren E. Casteel, Stefan T. Arold, Banumathi Sankaran, Choel Kim, Friedrich W. Herberg

المصدر: Structure (London, England : 1993), vol 24, iss 5
Kim, JJ; Lorenz, R; Arold, ST; Reger, AS; Sankaran, B; Casteel, DE; et al.(2016). Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation. Structure, 24(5), 710-720. doi: 10.1016/j.str.2016.03.009. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/8q56g7g4Test

مصطلحات موضوعية: 0301 basic medicine, crystal structure, second messengers, 1.1 Normal biological development and functioning, allosteric activation, Allosteric regulation, Biophysics, Plasma protein binding, Molecular Dynamics Simulation, Crystallography, X-Ray, Article, 03 medical and health sciences, chemistry.chemical_compound, NO-cGMP signaling, Underpinning research, Structural Biology, Information and Computing Sciences, cyclic nucleotide-binding domain, Humans, 2.1 Biological and endogenous factors, Aetiology, Binding site, Protein kinase A, Cyclic GMP, Molecular Biology, Cyclic guanosine monophosphate, Cyclic GMP-Dependent Protein Kinase Type I, Crystallography, Binding Sites, 030102 biochemistry & molecular biology, Chemistry, Biological Sciences, Cell biology, Molecular Docking Simulation, 030104 developmental biology, Cyclic nucleotide-binding domain, cGMP-dependent protein kinase, small-angle X-ray scattering, Chemical Sciences, Second messenger system, cardiovascular system, X-Ray, Protein Multimerization, Protein Binding

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2fb2e3ab12b4c73bc1c9f951f34d814Test
https://doi.org/10.1016/j.str.2016.03.009Test

المؤلفون: Robin Lorenz, Choel Kim, Daniel He, Friedrich W. Herberg, Chinten James Lim

مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, Biology, Biochemistry, Article, 03 medical and health sciences, chemistry.chemical_compound, Cyclic nucleotide, Mice, Protein structure, Protein Domains, Cyclic nucleotide binding, Animals, Cyclic adenosine monophosphate, Nucleotide, Protein kinase A, Cyclic guanosine monophosphate, chemistry.chemical_classification, 030102 biochemistry & molecular biology, Kinase, General Medicine, Fibroblasts, Cyclic AMP-Dependent Protein Kinases, 030104 developmental biology, chemistry, Mutation, Molecular Medicine, Nucleotides, Cyclic, Gene Deletion, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7a86e9043faf3efdbd17bd04028367Test
https://europepmc.org/articles/PMC5892833Test/

المؤلفون: Choel Kim, Chi Zhao, Jeong Joo Kim, Gilbert Huang, Albert S. Reger, Daniela Bertinetti, Rajeevan Selvaratnam, Friedrich W. Herberg, Darren E. Casteel, Giuseppe Melacini, Eui Whan Moon, James W. Pflugrath, Banumathi Sankaran, Bryan VanSchouwen, Robin Lorenz

المصدر: Structure. 22:116-124

مصطلحات موضوعية: Models, Molecular, Molecular Sequence Data, Phosphodiesterase 3, Gene Expression, Biology, Arginine, Crystallography, X-Ray, Article, Cyclic nucleotide, chemistry.chemical_compound, Leucine, Structural Biology, Catalytic Domain, Cyclic AMP, Escherichia coli, Humans, Amino Acid Sequence, Binding site, Cyclic nucleotide-gated ion channel, Cyclic GMP, Molecular Biology, Cyclic guanosine monophosphate, Cyclic GMP-Dependent Protein Kinase Type I, Binding Sites, CGMP binding, Recombinant Proteins, Kinetics, HEK293 Cells, chemistry, Biochemistry, Cyclic nucleotide-binding domain, Mutagenesis, Site-Directed, Biophysics, Thermodynamics, PDE10A, Sequence Alignment, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc76169bed1c8f7d0a7d81a6d9460755Test
https://doi.org/10.1016/j.str.2013.09.021Test

المؤلفون: Banumathi Sankaran, Matthew Auton, Venkata R. Machha, Linda M. Benson, James C. Campbell, Alexander Tischer, Choel Kim, Laurie L. Moon-Tasson

المصدر: The Journal of biological chemistry, vol 291, iss 8
Tischer, A; Campbell, JC; Machha, VR; Moon-Tasson, L; Benson, LM; Sankaran, B; et al.(2016). Mutational constraints on local unfolding inhibit the rheological adaptation of von willebrand factor. Journal of Biological Chemistry, 291(8), 3848-3859. doi: 10.1074/jbc.M115.703850. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/8cr2112pTest

مصطلحات موضوعية: 0301 basic medicine, Plasma protein binding, 030204 cardiovascular system & hematology, von Willebrand factor, Biochemistry, Medical and Health Sciences, 0302 clinical medicine, Protein structure, Native state, structural biology, Platelet, platelet glycoprotein Ib, Hemostatic function, mass spectrometry, biology, Chemistry, Platelet Glycoprotein GPIb-IX Complex, Biological Sciences, trypsin, protein stability, Protein Structure and Folding, Rheology, surface plasmon resonance, Protein Binding, Protein Structure, Biochemistry & Molecular Biology, Mutation, Missense, protein denaturation, 03 medical and health sciences, Von Willebrand factor, von Willebrand Factor, Von Willebrand disease, medicine, Humans, Molecular Biology, x-ray crystallography, Protein Unfolding, Hydrogen Bonding, Cell Biology, medicine.disease, Protein Structure, Tertiary, 030104 developmental biology, Mutation, Chemical Sciences, biology.protein, Biophysics, Missense, Tertiary

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe73ad6bf595fa5a4446d0b602597aceTest
https://escholarship.org/uc/item/8cr2112pTest

المؤلفون: Jerrold M. Olefsky, Dimitrios Davalos, Eirini Vagena, Alan R. Saltiel, Natacha Le Moan, Benjamin D. Sachs, Pingping Li, Christian Schachtrup, Choel Kim, Katerina Akassoglou, Bernat Baeza-Raja, Dave Bridges

المصدر: Proceedings of the National Academy of Sciences. 109:5838-5843

مصطلحات موضوعية: Snf3, medicine.medical_specialty, Glucose uptake, Molecular Sequence Data, Carbohydrate metabolism, Receptor, Nerve Growth Factor, Mice, Insulin resistance, Internal medicine, Adipocytes, medicine, Animals, Homeostasis, Humans, Glucose homeostasis, Amino Acid Sequence, Muscle, Skeletal, rab5 GTP-Binding Proteins, Muscle Cells, Glucose Transporter Type 4, Multidisciplinary, biology, Body Weight, Glucose transporter, Biological Sciences, medicine.disease, Protein Structure, Tertiary, Protein Transport, Insulin receptor, Glucose, HEK293 Cells, Endocrinology, rab GTP-Binding Proteins, biology.protein, sense organs, Insulin Resistance, GLUT4, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b59d29c76d6742a8578bbb1404c4e53Test
https://doi.org/10.1073/pnas.1103638109Test

المؤلفون: Nikki Cheung, Susan S. Taylor, Choel Kim, Jian Wu, Jessica G.H. Bruystens, Juniper Pennypacker, Angela J. Boettcher, Donald A. Blumenthal, Alexandr P. Kornev, Jie Yang

المصدر: Structure. 19:265-276

مصطلحات موضوعية: Models, Molecular, Protein Conformation, Tetrameric protein, Stereochemistry, Cyclic AMP-Dependent Protein Kinase RIalpha Subunit, Protein subunit, Molecular Sequence Data, Allosteric regulation, Gene Expression, Cooperativity, Biology, Article, Protein structure, Allosteric Regulation, X-Ray Diffraction, Tetramer, Holoenzymes, Structural Biology, Catalytic Domain, Scattering, Small Angle, Cyclic AMP, Animals, Humans, Amino Acid Sequence, Molecular Biology, Sequence Homology, Amino Acid, Recombinant Proteins, Enzyme Activation, Kinetics, Protein Subunits, Crystallography, Mutation, CAMP binding, Protein Multimerization, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463a5a46bfca7d1d0eda2e1b48834e38Test
https://doi.org/10.1016/j.str.2010.12.005Test

المؤلفون: Jian Wu, Choel Kim, Kimberly Alberto, Simon H. J. Brown, Susan S. Taylor

المصدر: Journal of Molecular Biology. 393:1070-1082

مصطلحات موضوعية: Models, Molecular, Stereochemistry, Protein subunit, Adenylyl Imidodiphosphate, Molecular Sequence Data, Protein Data Bank (RCSB PDB), Plasma protein binding, Biology, Crystallography, X-Ray, Article, Protein Structure, Secondary, Substrate Specificity, Protein structure, Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit, Structural Biology, Enzyme Stability, Animals, Amino Acid Sequence, Amino Acids, Protein kinase A, Molecular Biology, Rats, Isoenzymes, Protein Subunits, Biochemistry, Docking (molecular), Cyclic nucleotide-binding domain, Crystallization, Holoenzymes, Linker, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d3d31f185ed6b87146499b0a43993fTest
https://doi.org/10.1016/j.jmb.2009.09.014Test

المؤلفون: Cecilia Y. Cheng, Choel Kim, Jian Wu, Susan S. Taylor, Simon H. J. Brown, Natarajan Kannan

المصدر: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1784:16-26

مصطلحات موضوعية: Protein Conformation, Protein subunit, Allosteric regulation, Biophysics, Biology, Biochemistry, Article, Analytical Chemistry, Protein–protein interaction, Protein structure, Cyclic nucleotide binding, Catalytic Domain, Cyclic AMP, Animals, Protein Isoforms, Protein kinase A, Protein Kinase Inhibitors, Molecular Biology, Protein kinase C, Intracellular Signaling Peptides and Proteins, Cyclic AMP-Dependent Protein Kinases, Protein Subunits, Drug Design, Casein kinase 2, Holoenzymes, Protein Binding, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd5ff022b9643a2abe2300a9327c08bTest
https://doi.org/10.1016/j.bbapap.2007.10.002Test

المؤلفون: Susan S. Taylor, Choel Kim, Cecilia Y. Cheng, S. Adrian Saldanha

المصدر: Cell. 130:1032-1043

مصطلحات موضوعية: Models, Molecular, Conformational change, Protein Conformation, Cyclic AMP-Dependent Protein Kinase RIalpha Subunit, Protein subunit, Amino Acid Motifs, Molecular Sequence Data, Glutamic Acid, Plasma protein binding, Biology, Arginine, Crystallography, X-Ray, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Enzyme activator, chemistry.chemical_compound, Protein structure, Catalytic Domain, Cyclic AMP, Cyclic adenosine monophosphate, Amino Acid Sequence, Binding site, Protein kinase A, 030304 developmental biology, 0303 health sciences, Binding Sites, Biochemistry, Genetics and Molecular Biology(all), Adenine, 030302 biochemistry & molecular biology, Tryptophan, Cyclic AMP-Dependent Protein Kinases, Protein Structure, Tertiary, Enzyme Activation, Biochemistry, chemistry, SIGNALING, Mutagenesis, Site-Directed, Biophysics, Tyrosine, CELLBIO, Holoenzymes, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e59c5256e2451d954c70c05146918bdTest
https://doi.org/10.1016/j.cell.2007.07.018Test