المؤلفون: Kench, James G, Amin, Mahul B, Berney, Daniel M, Compérat, Eva M, Cree, Ian A, Gill, Anthony J, Hartmann, Arndt, Menon, Santosh, Moch, Holger, Netto, George J, Raspollini, Maria R, Rubin, Mark A, Tan, Puay Hoon, Tsuzuki, Toyonori, Turjalic, Samra, van der Kwast, Theo H, Zhou, Ming, Srigley, John R

المصدر: Histopathology; Oct2022, Vol. 81 Issue 4, p447-458, 12p

مصطلحات موضوعية: BASAL cell carcinoma, MALE reproductive organs, PROSTATE cancer, ANDROGEN deprivation therapy, NEUROENDOCRINE tumors, SLEEP deprivation, ANDROGEN receptors

مستخلص: The fifth edition of the WHO Classification of Tumours of the Urinary and Male Genital Systems encompasses several updates to the classification and diagnosis of prostatic carcinoma as well as incorporating advancements in the assessment of its prognosis, including recent grading modifications. Some of the salient aspects include: (1) recognition that prostatic intraepithelial neoplasia (PIN)‐like carcinoma is not synonymous with a pattern of ductal carcinoma, but better classified as a subtype of acinar adenocarcinoma; (2) a specific section on treatment‐related neuroendocrine prostatic carcinoma in view of the tight correlation between androgen deprivation therapy and the development of prostatic carcinoma with neuroendocrine morphology, and the emerging data on lineage plasticity; (3) a terminology change of basal cell carcinoma to "adenoid cystic (basal cell) cell carcinoma" given the presence of an underlying MYB::NFIB gene fusion in many cases; (4) discussion of the current issues in the grading of acinar adenocarcinoma and the prognostic significance of cribriform growth patterns; and (5) more detailed coverage of intraductal carcinoma of prostate (IDC‐P) reflecting our increased knowledge of this entity, while recommending the descriptive term atypical intraductal proliferation (AIP) for lesions falling short of IDC‐P but containing more atypia than typically seen in high‐grade prostatic intraepithelial neoplasia (HGPIN). Lesions previously regarded as cribriform patterns of HGPIN are now included in the AIP category. This review discusses these developments, summarising the existing literature, as well as the emerging morphological and molecular data that underpins the classification and prognostication of prostatic carcinoma. [ABSTRACT FROM AUTHOR]

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المؤلفون: Egevad, Lars, Swanberg, Daniela, Delahunt, Brett, Ström, Peter, Kartasalo, Kimmo, Olsson, Henrik, Berney, Dan M., Bostwick, David G., Evans, Andrew J., Humphrey, Peter A., Iczkowski, Kenneth A., Kench, James G., Kristiansen, Glen, Leite, Katia R. M., McKenney, Jesse K., Oxley, Jon, Pan, Chin-Chen, Samaratunga, Hemamali, Srigley, John R., Takahashi, Hiroyuki, Tsuzuki, Toyonori, van der Kwast, Theo, Varma, Murali, Zhou, Ming, Clements, Mark, Eklund, Martin

مصطلحات موضوعية: Artificial intelligence, Grading, Pathology, Prostate cancer, Reproducibility, Standardization, 1307 Cell Biology, 1312 Molecular Biology, 2734 Pathology and Forensic Medicine

الوصف: The International Society of Urological Pathology (ISUP) hosts a reference image database supervised by experts with the purpose of establishing an international standard in prostate cancer grading. Here, we aimed to identify areas of grading difficulties and compare the results with those obtained from an artificial intelligence system trained in grading. In a series of 87 needle biopsies of cancers selected to include problematic cases, experts failed to reach a 2/3 consensus in 41.4% (36/87). Among consensus and non-consensus cases, the weighted kappa was 0.77 (range 0.68–0.84) and 0.50 (range 0.40–0.57), respectively. Among the non-consensus cases, four main causes of disagreement were identified: the distinction between Gleason score 3 + 3 with tangential cutting artifacts vs. Gleason score 3 + 4 with poorly formed or fused glands (13 cases), Gleason score 3 + 4 vs. 4 + 3 (7 cases), Gleason score 4 + 3 vs. 4 + 4 (8 cases) and the identification of a small component of Gleason pattern 5 (6 cases). The AI system obtained a weighted kappa value of 0.53 among the non-consensus cases, placing it as the observer with the sixth best reproducibility out of a total of 24. AI may serve as a decision support and decrease inter-observer variability by its ability to make consistent decisions. The grading of these cancer patterns that best predicts outcome and guides treatment warrants further clinical and genetic studies. Results of such investigations should be used to improve calibration of AI systems.

العلاقة: orcid:0000-0001-5796-1791; CAN 2017/210; Not set

الإتاحة: https://doi.org/10.1007/s00428-020-02858-wTest
https://espace.library.uq.edu.au/view/UQ:8a1bbd6Test

المؤلفون: Downes, Michelle R.¹ michelle.downes@sunnybrook.in, Srigley, John R.², Loblaw, Andrew³, Perlis, Nathan⁴, Ghai, Sangeet⁵, van der Kwast, Theodorus⁶

المصدر: Canadian Urological Association Journal. Apr2022, Vol. 16 Issue 4, pE227-E230. 4p.

مصطلحات موضوعية: *PROSTATE cancer, *PROSTATE biopsy, *RADICAL prostatectomy

مستخلص: The article presents the discussion on implementation and widespread use of multiparametric magnetic resonance imaging (mpMRI) in prostate cancer patients. Topics include targeting biopsies better predicting extraprostatic extension at prostatectomy, detecting anteriorly located tumors, and identifying perineural invasion; and biopsy being negative for carcinoma demonstrating the increased stroma, chronic inflammation, and atrophy.

المؤلفون: Egevad, Lars, Delahunt, Brett, Bostwick, David G., Cheng, Liang, Evans, Andrew J., Gianduzzo, Troy, Graefen, Markus, Hugosson, Jonas, Kench, James G., Leite, Katia R.M., Oxley, Jon, Sauter, Guido, Srigley, John R., Stattin, Pär, Tsuzuki, Toyonori, Yaxley, John, Samaratunga, Hemamali

المصدر: BJU International; Feb2021, Vol. 127 Issue 2, p165-168, 4p

مصطلحات موضوعية: PROGNOSIS, PROSTATE cancer, MEDICAL personnel, CORE needle biopsy, MALE reproductive organs, GLEASON grading system

مستخلص: Abbreviation ISUP International Society of Urological Pathology In November 2014, the International Society of Urological Pathology (ISUP) convened a consensus meeting in Chicago, Illinois, USA to consider grading criteria for prostatic adenocarcinoma [1]. While cribriform cancer used to be included in either Gleason pattern 3 or 4, depending on the size and shape of the glands, the ISUP 2014 revision considers all cribriform cancer to be Gleason pattern 4, or even 5 if comedonecrosis is present [19]. An explanation for this increasing interest may be that the Gleason inflation that was fueled by the ISUP 2005 consensus recommendations has pushed a considerable number of cancers from Gleason score 6 to 7 [21]. The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: definition of grading patterns and proposal for a new grading system. [Extracted from the article]

: Copyright of BJU International is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Kench, James G., Judge, Meagan, Delahunt, Brett, Humphrey, Peter A., Kristiansen, Glen, Oxley, Jon, Rasiah, Krishan, Takahashi, Hiroyuki, Trpkov, Kiril, Varma, Murali, Wheeler, Thomas M., Zhou, Ming, Srigley, John R., Egevad, Lars

المصدر: Virchows Archiv: European Journal of Pathology; Sep2019, Vol. 475 Issue 3, p263-277, 15p

مستخلص: The International Collaboration on Cancer Reporting (ICCR) was formed in 2011 to harmonise the datasets, protocols and checklists for pathological reporting of various cancers and develop internationally agreed upon, evidence-based datasets. A dataset for prostate cancer in radical prostatectomy specimens was developed in 2011-2012 as part of a pilot project; however, it required substantial revision following the ISUP Consensus Conference on Gleason Grading in 2014, the publication of the World Health Organisation (WHO) Classification of Tumours of the Urinary System and Male Genital Organs in 2016, and the 8th edition of the Tumour-Node-Metastasis (TNM) staging system in late 2016. This article presents the up-to-date, evidence-based ICCR dataset and associated commentary for reporting prostate cancer in radical prostatectomy specimens. PubMed and Google search engines were used to review the published literature on the subject, and the dataset was developed in line with the previously published ICCR framework for the development of cancer datasets. Substantial changes have been incorporated into the second edition of the ICCR prostate cancer (radical prostatectomy) dataset. These include revisions to prostate cancer grading, reporting of intraductal carcinoma of prostate and surgical margins, among others. Up-to-date cancer datasets underpin structured reporting and facilitate the production of consistent and accurate pathological data for patient care as well as comparisons between different cohorts and populations internationally. [ABSTRACT FROM AUTHOR]

: Copyright of Virchows Archiv: European Journal of Pathology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Egevad, Lars, Delahunt, Brett, Srigley, John R., Samaratunga, Hemamali

مصطلحات موضوعية: Prostate cancer, Grading, ISUP grade, Gleason grade, 2723 Immunology and Allergy, 2726 Microbiology (medical), 2734 Pathology and Forensic Medicine

الوصف: The International Society of Urological Pathology (ISUP) has issued guidelines for the grading of prostate cancer based on a consensus conference held in 2014. The recommendations resulting from the 2014 consensus conference were a further development of 2005 ISUP modified Gleason grading. In the 2014 system, morphological criteria are clarified, including updated definitions of Gleason pattern 4. In addition to the continued reporting of Gleason scores, we also recommend that Gleason scores 6, 3+4=7, 4+3=7, 8 and 9-10, respectively, be reported as five groups, i.e. ISUP grades 1-5. This new grading system has the dual benefit of predicting patient outcome as well as facilitating patient communication.

العلاقة: orcid:0000-0001-5796-1791

الإتاحة: https://doi.org/10.1111/apm.12533Test
https://espace.library.uq.edu.au/view/UQ:390611Test

المؤلفون: Kweldam, Charlotte F., Nieboer, Daan, Algaba, Ferran, Amin, Mahul B., Berney, Dan M., Billis, Athanase, Bostwick, David G., Bubendorf, Lukas, Cheng, Liang, Comperat, Eva, Delahunt, Brett, Egevad, Lars, Evans, Andrew J., Hansel, Donna E., Humphrey, Peter A., Kristiansen, Glen, van der Kwast, Theodorus H., Magi-Galluzzi, Cristina, Montironi, Rodolfo, Netto, George J., Samaratunga, Hemamali, Srigley, John R., Tan, Puay H., Varma, Murali, Zhou, Ming, van Leenders, Geert J. L. H.

مصطلحات موضوعية: Gleason grading, Interobserver variability, Prostate cancer, 2722 Histology, 2734 Pathology and Forensic Medicine

الوصف: Aims: To assess the interobserver reproducibility of individual Gleason grade 4 growth patterns. Methods and results: Twenty-three genitourinary pathologists participated in the evaluation of 60 selected high-magnification photographs. The selection included 10 cases of Gleason grade 3, 40 of Gleason grade 4 (10 per growth pattern), and 10 of Gleason grade 5. Participants were asked to select a single predominant Gleason grade per case (3, 4, or 5), and to indicate the predominant Gleason grade 4 growth pattern, if present. ‘Consensus’ was defined as at least 80% agreement, and ‘favoured’ as 60–80% agreement. Consensus on Gleason grading was reached in 47 of 60 (78%) cases, 35 of which were assigned to grade 4. In the 13 non-consensus cases, ill-formed (6/13, 46%) and fused (7/13, 54%) patterns were involved in the disagreement. Among the 20 cases where at least one pathologist assigned the ill-formed growth pattern, none (0%, 0/20) reached consensus. Consensus for fused, cribriform and glomeruloid glands was reached in 2%, 23% and 38% of cases, respectively. In nine of 35 (26%) consensus Gleason grade 4 cases, participants disagreed on the growth pattern. Six of these were characterized by large epithelial proliferations with delicate intervening fibrovascular cores, which were alternatively given the designation fused or cribriform growth pattern (‘complex fused’). Conclusions: Consensus on Gleason grade 4 growth pattern was predominantly reached on cribriform and glomeruloid patterns, but rarely on ill-formed and fused glands. The complex fused glands seem to constitute a borderline pattern of unknown prognostic significance on which a consensus could not be reached.

العلاقة: orcid:0000-0001-5796-1791

الإتاحة: https://doi.org/10.1111/his.12976Test
https://espace.library.uq.edu.au/view/UQ:408811/UQ408811_OA.pdfTest
https://espace.library.uq.edu.au/view/UQ:408811Test

المؤلفون: Seipel, Amanda H., Delahunt, Brett, Samaratunga, Hemamali, Amin, Mahul, Barton, Joel, Berney, Daniel M., Billis, Athanase, Cheng, Liang, Comperat, Eva, Evans, Andrew, Fine, Samson W., Grignon, David, Humphrey, Peter A., Magi-Galluzzi, Cristina, Montironi, Rodolfo, Sesterhenn, Isabell, Srigley, John R., Trpkov, Kiril, van der Kwast, Theo, Varma, Murali, Zhou, Ming, Ahmad, Amar, Moss, Sue, Egevad, Lars

مصطلحات موضوعية: Ductal cancer, Pathology, Prostate cancer, Prostatectomy

الوصف: Aims: Ductal adenocarcinoma of the prostate (DAC) is clinically important, because its behaviour may differ from that of acinar adenocarcinoma. Our aims were to investigate the interobserver variability of this diagnosis among experts in uropathology and to define diagnostic criteria.

العلاقة: orcid:0000-0001-5796-1791

الإتاحة: https://doi.org/10.1111/his.12382Test
https://espace.library.uq.edu.au/view/UQ:694678Test

المؤلفون: Samaratunga, Hemamali, Delahunt, Brett, Srigley, John R, Yaxley, John, Johannsen, Shulammite, Coughlin, Geoffrey, Gianduzzo, Troy, Kua, Boon, Patterson, Imogen, Nacey, John N, Egevad, Lars

المصدر: Histopathology; Oct2017, Vol. 71 Issue 4, p641-647, 7p, 1 Color Photograph, 1 Chart

مصطلحات موضوعية: PROSTATE cancer, MUCINOUS adenocarcinoma, MUCINS, PROSTATE-specific antigen, CANCER relapse, BIOCHEMISTRY, SEMINAL vesicles

مستخلص: Aim The clinical significance of mucinous prostatic adenocarcinoma ( PCa) remains uncertain. Methods From 6440 cases of PCa treated by radical prostatectomy from 2009 to 2014, mucinous components of 5-100% were found in 143 (2.2%) cases. Results The mean age was 61.4 years, mean pre-operative serum prostate-specific antigen ( PSA) was 7.8 ng/ml and clinical stage category was cT1 in 81% and cT2 in 19% of cases. Cases were graded using the 2014 International Society of Urological Pathology recommendation of grading underlying architecture, and Gleason scores ( GS) were 3 + 4 in 13.3%, 4 + 3 in 54.5%, 4 + 4 in 2.1%, 3 + 4 or 4 + 3 with tertiary 5 in 11.9% and 9-10 in 18.2%. The mucinous component invariably had a high-grade component. Extraprostatic extension was found in 46.8% of cases. In 21.6%, tumour volume was ≥3 cm³ and 9.7% had surgical margin positivity. Seminal vesicle involvement was found in 6.9%. In 73 cases the mucinous component was >25%, and when cases were divided on the basis of the area of mucin present (≤25 versus >25%) there was no significant difference between clinical or pathological features. Similar findings were achieved when cases were compared with grade-matched non-mucinous carcinoma controls. The 5-year biochemical recurrence rates for mucinous versus non-mucinous cancer were 12.5 versus 17% ( P = 0.15). Conclusion PCa with mucinous components is often high grade; however, the prognosis appears to be similar to non-mucinous cancers of similar GS. [ABSTRACT FROM AUTHOR]

: Copyright of Histopathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Kench, James G., Clouston, David R., Delprado, Warick, Eade, Thomas, Ellis, Dllis, Horvath, Lisa G., Samaratunga, Hemamali, Stahl, Jurgen, Stapleton, Alan M. F., Egevad, Lars, Srigley, John R., Delahunt, Brett

مصطلحات موضوعية: Pathology, Prognostic factors, Prostate cancer, Radical prostatectomy, 2734 Pathology and Forensic Medicine

الوصف: Prostate cancer is the most common visceral cancer and the second most common cause of cancer death in males. The number of radical prostatectomies performed each year is increasing and accurate data from the histopathological examination of these specimens aid clinicians in stratifying patients for surveillance and adjuvant therapies. This review focuses on the histopathological prognostic factors which should be routinely recorded in pathology reports and complements the Royal College of Pathologists of Australasia Structured Reporting Protocol for Prostate Cancer (Radical Prostatectomy). Such structured pathology reports have been shown to significantly enhance the completeness and quality of data provided to clinicians. The review also discusses the International Society for Urological Pathology Consensus Conference recommendations which were published recently.

العلاقة: orcid:0000-0001-5796-1791

الإتاحة: https://doi.org/10.1097/PAT.0b013e328348a6b3Test
https://espace.library.uq.edu.au/view/UQ:336388Test