التفاصيل البيبلوغرافية
| العنوان: |
A direct comparison of contrast-enhanced ultrasound and dynamic contrast-enhanced magnetic resonance imaging for prostate cancer detection and prediction of aggressiveness. |
| المؤلفون: |
Baur, Alexander D. J.1 alexander.baur@charite.de, Schwabe, Julia2, Rogasch, Julian3, Maxeiner, Andreas4, Penzkofer, Tobias1, Stephan, Carsten4,5, Rudl, Marc5,6, Hamm, Bernd1, Jung, Ernst-Michael7, Fischer, Thom2 |
| المصدر: |
European Radiology. May2018, Vol. 28 Issue 5, p1949-1960. 12p. 4 Charts, 4 Graphs. |
| مصطلحات موضوعية: |
*ENDORECTAL ultrasonography, *MAGNETIC resonance imaging, *EXOCRINE glands, *CONTRAST-enhanced ultrasound, *BIOPSY, *PROSTATE tumors, *CANCER invasiveness, *COMPARATIVE studies, *ENDOSCOPIC ultrasonography, *RESEARCH methodology, *MEDICAL cooperation, *PROSTATE, *RECTUM, *RESEARCH, *EVALUATION research, *PREDICTIVE tests, *CONTRAST media, *TUMOR grading, *DIAGNOSIS |
| مستخلص: |
Introduction: Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and contrast-enhanced ultrasound (CEUS) analyse tissue vascularization. We evaluated if CEUS can provide comparable information as DCE-MRI for the detection of prostate cancer (PCa) and prediction of its aggressiveness.Material and Methods: A post-hoc evaluation of 92 patients was performed. In each patient CEUS and DCE-MRI parameters of the most suspicious lesion identified on MRI were analysed. The predictive values for discrimination between benign lesions, low-/intermediate- and high-grade PCa were evaluated. Results of targeted biopsy served as reference standard (benign lesions, n=51; low- and intermediate-grade PCa [Gleason grade group 1 and 2], n=22; high-grade PCa [≥ Gleason grade group 3], n=19).Results: In peripheral zone lesions of all tested CEUS parameters only time to peak (TTPCEUS) showed significant differences between benign lesions and PCa (AUC 0.65). Of all tested DCE-MRI parameters, rate constant (Kep) was the best discriminator of high-grade PCa in the whole prostate (AUC 0.83) and in peripheral zone lesions (AUC 0.89).Conclusion: DCE-MRI showed a superior performance for detection of PCa and prediction of its aggressiveness. CEUS and DCE-MRI performed better in peripheral zone lesions than in transition zone lesions.Key Points: • DCE-MRI gathers information about vascularization and capillary permeability characteristics of tissues. • DCE-MRI can detect PCa and predict its aggressiveness. • CEUS also gathers information about vascularization of tissues. • For detection of PCa and prediction of aggressiveness DCE-MRI performed superiorly. • Both imaging techniques performed better in peripheral zone lesions. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
