Improvement of vascular endothelial function using the oral endothelin receptor antagonist bosentan in patients with systemic sclerosis
| العنوان: | Improvement of vascular endothelial function using the oral endothelin receptor antagonist bosentan in patients with systemic sclerosis |
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| المؤلفون: | M. Mavrikakis, Kalliopi Fragiadaki, Kimon Stamatelopoulos, P. Katsichti, Christos Papamichael, Christodoulos Stefanadis, Dimitrios Tousoulis, P.P. Sfikakis |
| المصدر: | Arthritis & Rheumatism. 56:1985-1993 |
| بيانات النشر: | Wiley, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Endothelin Receptor Antagonists, Male, Vascular Endothelial Growth Factor A, medicine.medical_specialty, Brachial Artery, Endothelium, Hypertension, Pulmonary, Immunology, Administration, Oral, Rheumatology, Internal medicine, medicine, Humans, Immunology and Allergy, Pharmacology (medical), Prospective Studies, Endothelial dysfunction, Aged, Ultrasonography, Sulfonamides, Scleroderma, Systemic, Dose-Response Relationship, Drug, Endothelin-1, Endothelin receptor antagonist, business.industry, Bosentan, Middle Aged, Intercellular Adhesion Molecule-1, medicine.disease, Pulmonary hypertension, Endothelin 1, Vasodilation, Blood pressure, Endocrinology, medicine.anatomical_structure, Regional Blood Flow, Cardiology, Female, Endothelium, Vascular, E-Selectin, Endothelin receptor, business, medicine.drug |
| الوصف: | Objective Increased endothelin activity may play a role in the pathogenesis of vascular injury, a primary feature of systemic sclerosis (SSc; scleroderma). Our goal was to test the hypothesis that treatment with the oral endothelin receptor antagonist bosentan might improve vascular endothelial function in SSc patients. Methods A 4-week, prospective, parallel-group study compared 12 SSc patients who did not receive bosentan treatment with 12 patients who did receive treatment (125 mg/day) for pulmonary hypertension and/or digital ulcers. There were no differences in demographic and clinical characteristics or medications between the 2 groups. Baseline endothelial dysfunction was documented by decreased brachial artery ultrasound-derived flow-mediated dilation (FMD% |
| تدمد: | 1529-0131 0004-3591 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf8041881f4c0f20cce89ec7e1acdeb9Test https://doi.org/10.1002/art.22634Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bf8041881f4c0f20cce89ec7e1acdeb9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15290131 00043591 |
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