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Prenatal antidepressant exposure and emotional disorders until age 22: a danish register study

التفاصيل البيبلوغرافية
العنوان: Prenatal antidepressant exposure and emotional disorders until age 22: a danish register study
المؤلفون: Mette Bliddal, Rikke Wesselhoeft, Katrine Strandberg-Larsen, Martin T. Ernst, Myrna M. Weissman, Jay A. Gingrich, Ardesheer Talati, Anton Pottegård
المصدر: Child and Adolescent Psychiatry and Mental Health, Vol 17, Iss 1, Pp 1-12 (2023)
بيانات النشر: BMC, 2023.
سنة النشر: 2023
المجموعة: LCC:Pediatrics
LCC:Psychiatry
مصطلحات موضوعية: Depression, Antidepressant, Selective serotonin reuptake inhibitor (SSRI), Prenatal exposure, Birth cohort, Propensity score, Pediatrics, RJ1-570, Psychiatry, RC435-571
الوصف: Abstract Background Selective serotonin reuptake inhibitors (SSRIs) are the most frequently prescribed antidepressants in pregnancy. Animal and some clinical studies have suggested potential increases in depression and anxiety following prenatal SSRI exposure, but the extent to which these are driven by the medication remains unclear. We used Danish population data to test associations between maternal SSRI use during pregnancy and children outcomes up to age 22. Methods We prospectively followed 1,094,202 single-birth Danish children born 1997–2015. The primary exposure was ≥ 1 SSRI prescription filled during pregnancy; the primary outcome, first diagnosis of a depressive, anxiety, or adjustment disorder, or redeemed prescription for an antidepressant medication. We used propensity score weights to adjust potential confounders, and incorporated data from the Danish National Birth Cohort (1997–2003) to further quantify potential residual confounding by subclinical factors. Results The final dataset included 15,651 exposed and 896,818 unexposed, children. After adjustments, SSRI-exposed had higher rates of the primary outcome than those of mothers who either did not use an SSRI (HR = 1.55 [95%CI:1.44,1.67] or discontinued the SSRI use ≥ 3 months prior to conception (HR = 1.23 [1.13,1.34]). Age of onset was earlier among exposed (9 [IQR:7–13] years) versus unexposed (12 [IQR:12–17] years) children (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1753-2000
العلاقة: https://doaj.org/toc/1753-2000Test
DOI: 10.1186/s13034-023-00624-9
الوصول الحر: https://doaj.org/article/2bc64d6b347647f28e2855c0a7bc3b93Test
رقم الانضمام: edsdoj.2bc64d6b347647f28e2855c0a7bc3b93
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17532000
DOI:10.1186/s13034-023-00624-9