التفاصيل البيبلوغرافية
| العنوان: |
Bintrafusp Alfa: A Bifunctional Fusion Protein Targeting PD-L1 and TGF-β, in Patients with Pretreated Colorectal Cancer: Results from a Phase I Trial. |
| المؤلفون: |
Spira, Alexander, Wertheim, Michael S, Kim, Edward J, Tan, Benjamin, Lenz, Heinz-Josef, Nikolinakos, Petros, Rich, Patricia L, Jehl, Genevieve, Machl, Andreas, Ito, Rena, Gulley, James L, Kopetz, Scott |
| المصدر: |
Oncologist; Feb2023, Vol. 28 Issue 2, pe124-e127, 4p, 1 Chart, 1 Graph |
| مصطلحات موضوعية: |
TRANSFORMING growth factors-beta, PROGRAMMED death-ligand 1, CLINICAL trials, TREATMENT duration, COLORECTAL cancer, CANCER patients, TREATMENT effectiveness, RESEARCH funding, DESCRIPTIVE statistics, RECOMBINANT proteins, PATIENT safety |
| مستخلص: |
Colorectal cancer (CRC) is a heterogeneous and complex disease with limited treatment options. Targeting transforming growth factor β (TGF-β) and programmed death ligand 1 pathways may enhance antitumor efficacy. Bintrafusp alfa is a first-in-class bifunctional fusion protein composed of the extracellular domain of TGF-β receptor II (a TGF-β "trap") fused to a human IgG1 monoclonal antibody blocking programmed cell death ligand 1. We report results from an expansion cohort of a phase I study (NCT02517398) in patients with heavily pretreated advanced CRC treated with bintrafusp alfa. As of May 15, 2020, 32 patients with advanced CRC had received bintrafusp alfa for a median duration of 7.1 weeks. The objective response rate was 3.1% and the disease control rate was 6.3% (1 partial response, 1 stable disease); 2 patients were not evaluable. The safety profile was consistent with previously reported data. A phase I study of bintrafusp alfa showed early signs of clinical efficacy and a manageable safety profile in patients with heavily pretreated solid tumors. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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