التفاصيل البيبلوغرافية
| العنوان: |
A prognostic scoring system for adult patients less than 60 years of age with acute lymphoblastic leukemia in first relapse. |
| المؤلفون: |
Advani, Anjali, Jin, Tao, Bolwell, Brian, Copelan, Edward, Sekeres, Mikkael, Sobecks, Ronald, Sungren, Shawnda, Yurch, Melissa, Kalaycio, Matt |
| المصدر: |
Leukemia & Lymphoma; Jul2009, Vol. 50 Issue 7, p1126-1131, 6p, 1 Diagram, 4 Charts, 2 Graphs |
| مصطلحات موضوعية: |
LYMPHOBLASTIC leukemia, BONE marrow transplantation, LACTATE dehydrogenase, PROGNOSTIC tests, GRAFT versus host disease, CLINICAL trials |
| مستخلص: |
The outcome of patients with acute lymphoblastic leukemia (ALL) in first relapse is poor. We retrospectively evaluated patients with ALL in first relapse, 18-60 years of age, to define a prognostic score. For all patients, a scoring system of 0-3 was developed with 1 point for each of the following: age at diagnosis ≥45 years, lactate dehydrogenase (LDH) at the time of relapse ≥1.5 times upper limits of normal (ULN), not proceeding to allogeneic bone marrow transplant (BMT). A similar scoring system was developed for patients proceeding to BMT. LDH ≥1.5 times ULN at the time of relapse predicted poor overall survival. Patients with a prognostic score of greater than 1 have a poor prognosis, even with BMT, and should be considered for treatment with innovative approaches such as Phase 1 clinical trials. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
