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1دورية أكاديمية
المؤلفون: Tirosh, Amit, Papadakis, Georgios Z, Chittiboina, Prashant, Lyssikatos, Charalampos, Belyavskaya, Elena, Keil, Meg, Lodish, Maya B, Stratakis, Constantine A
المصدر: Hormone and Metabolic Research. 49(06)
مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Cancer, Rare Diseases, Clinical Research, Biomedical Imaging, Acromegaly, Adolescent, Adult, Child, Child, Preschool, Female, Growth Hormone-Secreting Pituitary Adenoma, Human Growth Hormone, Humans, Imaging, Three-Dimensional, Insulin-Like Growth Factor I, Magnetic Resonance Imaging, Male, Middle Aged, Pituitary Gland, Prognosis, Treatment Outcome, Young Adult, volumetric measurement, acromegaly, hypopituitarism, Endocrinology & Metabolism, Clinical sciences
الوصف: There is scarce data on the clinical utility of volume measurement for growth hormone (GH)-secreting pituitary adenomas. The current study objective was to assess the association between pituitary adenoma volumes and baseline endocrine evaluation, initial surgical success rate, and disease control among patients with acromegaly. A retrospective cohort study was conducted at a clinical research center including patients with acromegaly due to GH-secreting pituitary adenomas. Baseline hormonal evaluation and adenoma characteristics according to MRI were collected. Volumetric measurements of pituitary adenomas were performed using a semi-automated lesion segmentation and tumor-volume assessment tools. Rates of post-operative medical treatment, radiation therapy, and re-operation were gathered from the patients' medical records. Twenty seven patients (11 females) were included, median age 21.0 years (interquartile range 29 years, range 3-61 years). Patients harboring adenomas with a volume
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/9b93b2xrTest
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2دورية أكاديمية
المؤلفون: Papadakis, Georgios Z., Mavroudis, Dimitrios, Georgoulias, Vasilios, Souglakos, John, Alegakis, Athanasios K.
المصدر: Scopus Export 2015-2019
مصطلحات موضوعية: Biomarkers, Circulating tumor cells (CTCs), Early breast cancer (EBC), IGF-binding protein-3 (IGFBP-3), Insulin-like growth factor-1 (IGF-1), Prognosis
الوصف: Objective Insulin-like growth factor (IGF)-axis is involved in human oncogenesis and metastasis development for various solid tumors including breast cancer. Aim of this study was to assess the association between IGF-1, IGF-binding protein-3 (IGFBP-3) serum levels and the presence of circulating tumor cells (CTCs) in the peripheral blood of women diagnosed with early breast cancer (EBC), before and after adjuvant chemotherapy. Design 171 patients with early-stage breast adenocarcinomas were retrospectively evaluated. Immunoradiometric (IRMA) assays were employed for the in-vitro determination of IGF-1 and IGFBP-3 serum levels in blood samples collected after surgical treatment and before initiation of adjuvant chemotherapy. CTCs’ presence was assessed through detection of cytokeratin-19 (CK-19) mRNA transcripts using quantitative real time reverse transcription polymerase chain reaction (RT-PCR). IGF-1, IGFBP-3 serum levels were correlated with CTCs’ presence before and after adjuvant chemotherapy as well as with tumor characteristics including tumor size, axillary lymph node status, oestrogen (ER)/progestorene (PR) and human epidermural growth factor receptor 2 (HER2) receptor status. Log-rank test was applied to investigate possible association between IGF-1, IGFBP-3 serum levels and disease-free interval (DFI) and overall survival (OS). Results Before initiation of adjuvant therapy IGF-1, IGFBP-3 serum levels were moderately associated (Spearman's rho = 0.361, p < 0.001) with each other, while presenting significant differences across age groups (all p values < 0.05). IGF-1 serum levels did not correlate with the presence of CTCs before initiation (p = 0.558) or after completion (p = 0.474) of adjuvant chemotherapy. Similarly, IGFBP-3 serum levels did not show significant association with detectable CTCs either before (p = 0.487) or after (p = 0.134) completion of adjuvant chemotherapy. There was no statistically significant association between the clinical outcome of patients in terms of DFI, OS and ...
