دورية أكاديمية
Is elevated blood glucose at admission associated with poor outcomes in hospitalized COVID-19 patients?
| العنوان: | Is elevated blood glucose at admission associated with poor outcomes in hospitalized COVID-19 patients? |
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| المؤلفون: | Mariana Barbosa, Juliana Marques-Sá, Carla Carvalho, Vera Fernandes |
| المصدر: | Archives of Endocrinology and Metabolism, Vol 67, Iss 6 (2023) |
| بيانات النشر: | Brazilian Society of Endocrinology and Metabolism, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | Hyperglycemia, SARS-CoV-2, complications, prognosis, Medicine, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | ABSTRACT Objective: Hyperglycemia has been suggested as a risk factor for poor outcomes in coronavirus disease 2019 (COVID-19). The aim of our work was to evaluate the association between blood glucose levels at admission (BGA) and disease outcomes in hospitalized COVID-19 patients. Subjects and methods: Retrospective study including all adult COVID-19 patients admitted to a Portuguese hospital from March to August 2020 with BGA measurement. Subjects were categorized into two groups: BGA < 140 mg/dL and ≥ 140 mg/dL. Statistical analysis was performed using SPSSv26® (significance defined as p < 0.05). Results: We included 202 patients: median age 74 (60-86) years; 43.1% female; 31.2% with diabetes. The median BGA was 130.5 (108-158) mg/dL. When compared to normoglycemic, patients with BGA ≥ 140 mg/dL were older (p = 0.013), more vaccinated for influenza (p = 0.025) and had more comorbidities (hypertension, heart failure and peripheral arterial disease, p < 0.05). The last group presented higher leucocyte and neutrophile count, higher procalcitonin and prothrombin time, and lower lymphocyte count. Concerning prognosis, BGA ≥ 140 mg/dL was associated with higher rates of mechanical ventilation requirement and intensive care unit admission (p < 0.001), shock (p = 0.011), in-hospital mortality (p = 0.022) and 30-day mortality (p = 0.037). Considering only non-diabetic patients (n = 139), those with hyperglycemia presented higher rates of severity indicators (polypnea, SatO2 ≤ 93% and PaO2/FiO2 ≤ 300) and an association with poor outcomes was also found, namely mechanical ventilation requirement and in-hospital/30-day mortality (p < 0.05). Conclusion: Hyperglycemia at admission was associated with poor outcomes in COVID-19 patients, even in those without known pre-existing diabetes. Glycemic testing should be recommended for all COVID-19 patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2359-4292 2359-3997 |
| العلاقة: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972023000600206&lng=en&tlng=enTest; http://www.scielo.br/pdf/aem/v67n6/2359-4292-aem-67-06-e000649.pdfTest; https://doaj.org/toc/2359-4292Test |
| DOI: | 10.20945/2359-3997000000649 |
| الوصول الحر: | https://doaj.org/article/9c918f7893164fd8ac227fc0c94df500Test |
| رقم الانضمام: | edsdoj.9c918f7893164fd8ac227fc0c94df500 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23594292 23593997 |
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| DOI: | 10.20945/2359-3997000000649 |