دورية أكاديمية
The significance of second generation cardiac troponin I in early screening of hypoxic-ischemic encephalopathy after perinatal asphyxia
| العنوان: | The significance of second generation cardiac troponin I in early screening of hypoxic-ischemic encephalopathy after perinatal asphyxia |
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| المؤلفون: | Simović Aleksandra M., Igrutinović Zoran, Obradović Slobodan, Ristić Dragana, Vuletić Biljana, Radovanović Marija |
| المصدر: | Srpski Arhiv za Celokupno Lekarstvo, Vol 140, Iss 9-10, Pp 600-605 (2012) |
| بيانات النشر: | Serbian Medical Society, 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | hypoxic-ischemic encephalopathy, troponin I, newborn, prognosis, Medicine |
| الوصف: | Introduction. In the last few years the use of cardiac troponin I and T, as diagnostic and prognostic factors of ischemic myocardial injury both in adult and neonatal medicine has been of great interest. Objective. The objective of our research was to investigate the significance of cardiac troponin I (sTnI) as an early indicator of the presence and severity of hypoxic-ischemic encephalopathy (HIE) in newborns. Methods. We analyzed 55 term newborns with HIE diagnosed based on clinical findings and ultrasonographic examination of the central nervous system. Serum concentration of sTnIultra was determined by immunoenzyme method during the first 24-48 hours after birth, and the obtained findings were compared with the values of identical parameter in 36 healthy term newborns. Results. During the first 24-48 hrs after birth, serum concentration of sTnI-ultra was significantly higher (r0.12 μg/l indicated the development of significant cerebral damage with the sensitivity of 75% and specificity of 72.2%, while the sTnI-ultra level of >0.13 μg/l was a significant mortality predictor with sensitivity of 76.9% and specificity of 73.8%. Conclusion. The second generation cardiac troponin I assay highly correlates with clinical and ultrasonographic findings in neonates with HIE, so that it can be used as a significant diagnostic and prognostic indicator of this pathological condition. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Serbian |
| تدمد: | 0370-8179 |
| العلاقة: | https://doaj.org/toc/0370-8179Test |
| DOI: | 10.2298/SARH1210600S |
| الوصول الحر: | https://doaj.org/article/f6f2285af0a24b31aeb0ebc9b63d1f65Test |
| رقم الانضمام: | edsdoj.f6f2285af0a24b31aeb0ebc9b63d1f65 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 03708179 |
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| DOI: | 10.2298/SARH1210600S |