دورية أكاديمية
5-year overall survival after early breast cancer diagnosed during pregnancy: A retrospective case-control multicentre French study
| العنوان: | 5-year overall survival after early breast cancer diagnosed during pregnancy: A retrospective case-control multicentre French study |
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| المؤلفون: | Ploquin, A., Pistilli, B., Tresch, E., Frenel, J.S., Lerebours, F., Lesur, A., Loustalot, C., Bachelot, Thomas, Provansal, M., Ferrero, J.M., Coussy, F., Debled, M., Kerbrat, P., Vinceneux, A., Allouache, D., Morvan, F., Dalenc, F., Guiu, S., Rouzier, Roman, Vanlemmens, L. |
| المساهمون: | Service d'oncologie médicale (CHRU Lille), Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Département de médecine oncologique Gustave Roussy, Institut Gustave Roussy (IGR), Centre Régional de Lutte contre le Cancer Oscar Lambret Lille (UNICANCER/Lille), Université de Lille-UNICANCER, Institut de Cancérologie de l'Ouest Angers/Nantes (UNICANCER/ICO), UNICANCER, CRLCC René Huguenin (CRLCC René Huguenin), Hôpital René Huguenin Saint-Cloud, Institut Curie - Saint Cloud (ICSC)-Institut Curie - Saint Cloud (ICSC)-UNICANCER, Institut Curie Paris, Institut de Cancérologie de Lorraine - Alexis Vautrin Nancy (UNICANCER/ICL), Département d'oncologie médicale Centre Georges-François Leclerc, Centre Régional de Lutte contre le cancer Georges-François Leclerc Dijon (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Centre Léon Bérard Lyon, Institut Paoli-Calmettes (IPC), Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Centre de Lutte contre le Cancer Antoine Lacassagne Nice (UNICANCER/CAL), UNICANCER-Université Côte d'Azur (UniCA), Hôpital Saint-Louis, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Institut Bergonié Bordeaux, CRLCC Eugène Marquis (CRLCC), Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre Régional de Lutte contre le Cancer François Baclesse Caen (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier René Dubos Pontoise, Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Claudius Regaud, Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM) |
| المصدر: | ISSN: 0959-8049 ; European Journal of Cancer ; https://hal.umontpellier.fr/hal-02283141Test ; European Journal of Cancer, 2018, 95, pp.30-37. ⟨10.1016/j.ejca.2018.02.030⟩. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2018 |
| المجموعة: | Université Toulouse III - Paul Sabatier: HAL-UPS |
| مصطلحات موضوعية: | Breast cancer, Management, Pregnancy, Prognosis, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, [SDV.CAN]Life Sciences [q-bio]/Cancer |
| الوصف: | International audience ; BACKGROUND:Breast cancer diagnosed during pregnancy (BCP) is rare, but the prevalence is expected to rise. Long-term follow-up data regarding this clinically challenging condition are scarce. The main objective of this multicentre case-control French study was to compare the survival between pregnant patients and matched controls.METHODS:Patients from 27 centres diagnosed between 2000 and 2009 with histologically proven invasive breast cancer occurring during pregnancy were retrospectively included. Controls were matched to BCP patients on age, clinical T stage, hormone receptor, HER2, administration of neo-adjuvant chemotherapy and pathological node involvement in the absence of neo-adjuvant chemotherapy. Five-year overall survival (OS), disease-free survival (DFS) and metastasis-free survival (MFS) rates were estimated using the Kaplan-Meier method.RESULTS:One hundred and eleven BCP patients and 253 controls were included. Median age was 33 and 35 years, respectively. Both populations were managed similarly, except for less frequent sentinel node dissection (p = 0.026) and taxane administration (p = 0.03) among BCP patients. Median follow-up was 7.5 years. Survival rates were similar between both BCP and control patients: 5-year OS rates were 83.1% (95% CI: 74.5-89.0) vs 85.5% (95% CI: 80.4-89.4), respectively, p = 0.31; 5-year DFS rates 60.0% (95% CI: 50.1-68.6) vs 68.5% (95% CI: 62.3-73.9), respectively, p = 0.12 and 5-year MFS rates 71.0% (95% CI: 61.3-78.6) and 74.5% (95% CI: 68.6-79.5), respectively, p = 0.21.CONCLUSION:Our study showed that the survival outcomes of patients diagnosed with BCP were not significantly different as compared to those of matched non-pregnant controls. A proper management of women diagnosed with BCP is crucial. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/29625257; hal-02283141; https://hal.umontpellier.fr/hal-02283141Test; PUBMED: 29625257 |
| DOI: | 10.1016/j.ejca.2018.02.030 |
| الإتاحة: | https://doi.org/10.1016/j.ejca.2018.02.030Test https://hal.umontpellier.fr/hal-02283141Test |
| رقم الانضمام: | edsbas.98698DF7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ejca.2018.02.030 |
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