دورية أكاديمية
Association between age at disease onset of anti-neutrophil cytoplasmic antibody-associated vasculitis and clinical presentation and short-term outcomes
| العنوان: | Association between age at disease onset of anti-neutrophil cytoplasmic antibody-associated vasculitis and clinical presentation and short-term outcomes |
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| المؤلفون: | Monti S., Craven A., Klersy C., Montecucco C., Caporali R., Watts R., Merkel P. A., Luqmani R., Achilleos K., Adler M., Alba M. A., Albert D. A., Alibaz-Oner F., Allcoat P., Amano K., Amarasuriya M., Amudala N. A., Andrews J., Archer A. M., Arimura Y., Atukorala I., Azevedo E., Bajad S., Baldwin C., Barra L. J., Baslund B., Basu N., Baykal M., Berger C., Berglin E., Besada E., Bhardwaj M., Bischof A., Blockmans D., Blood J., Draibe J. B., Brand S., Brandao M., Bruce I. N., Butler A., Calabrese L. H., Ferrer D. C., Carette S., Carmona D., Ceunen H., Chakravarty K., Chapman P. T., Chocova Z., Chung S. A., Ci W., Cid M. C., Clark T. M., Clarkson M. R., De Jesus Contreras-Rodriguez F., Conway R., Cooke K., Viros X. C., Cordeiro A., Costa A., Culfear K., Daikeler T., Danda D., Das S. K., Dasgupta B., De Castro A. M., Dehghan N., Devassy R., Dhindsa N., Diamantopoulos A. P., Direskeneli H., Dobashi H., Juan D., Durrani M., Edelsten C., Eifert J., Elhayek S., Elsideeg S., Endo T., Erden A., Erer B., Eriksson P., Erturk Z., Espigol-Frigole G., Felicetti M., Ferraro A., Ferro J. M., Fifi-Mah A., Flores-Suarez L. F., Flossmann O., Flynn D., Fonseca J. E., Foot J., Foote M., Forbess L., Fujimoto S., Fukuoka K., Furtado C., Furuta S., Gaffo A. L., Gallagher P., Gao N., Gatenby P., Gendi N., Geraldes R., Gerits A., Gioffredi A., Gomples L., Goncalves M. J., Gondo P., Graham A., Grainger R., Gray D. T., Grayson P. C., Griffiths L., Guo Y., Gupta R., Gylling M., Hajj-Ali R. A., Hammam N., Harigai M., Hartley L., Haslett J., Hassan A., Hatemi G., Hellmich B., Henckaerts L., Henes J. C., Hepburn J., Herd V., Hess C., Hill C., Hinojosa-Azaola A., Hirahashi J., Hirano F., Hocevar A., Holle J., Hollinger N., Homma S., Howard T., Hoyles R. K., Hruskova Z., Hutcheon G., Ignacak M., Igney-Oertel A., Ikeda K., Ikegaya N., Jagadeesh S., Jaquith J., Jayne D. R. W., Jewell T., Jones C., Joshi A., Kalyoncu U., Kamall S., Kamath S., Lai K. S., Kaname S., Kanchinadham S., Karadag O., Karube M., Kaszuba M., Kaur R., Kawakami T., Kawashima S., Khalidi N., Khan A., Kikuchi M., Kilic L., Kimura M., King M. J., Klapa S., Klocke R., Kobayashi T., Kobayashi S., Komagata Y., Kronbichler A., Kuczia P., Kumar M. S., Kurosawa M., Lamprecht P., Langford C. A., Lanyon P., Laversuch C., Lee S. J., Leoni S., Li J., Liang K., Liang P., Liao H., Lee L. A., Luqmani R. A., Lyle A., Macdonald M., Mackie S. L., Madden L., Magliano M., Makino H., Makol A., Malaiya R., Malaviya A., Manthri R., Maritati F., Da Silva A. M., Mason J. C., Matara C., Matsui K., Matteson E. L., Mcbride D., Mccullough K., Mcgeoch L., Mclaren J., Mcmillian C., Mendiratta N., Menon A., Merinopoulos D., Merkel P., Messier S., Micheletti R. G., Mills K., Milman N., Minoda M., Minz R. W., Mock C., Mohammad A. J., Moiseev S., Moitinho M., Molloy E., Monach P. A., Montgomery M., Moosig F., Moradizadeh M., Morgan M., Morgan A. W., Morgan A. -M., Muir A., Mukhtyar C., Muller A., Muratore F., Muso E., Nada R., Nakajima H., Nakajima T., Nakano H., Nandagudi A., Neumann T., Ng Y. F., Ng K. H., Nogueira E. L., Nolkha N., Nordstrom D., Novikov P., Nugaliyadde A., O'donnell J. L., O'donoghue J., O'neill L., O'riordan E., Oatley M., Okubo K., Oliva E., Oshikawa H., Ota Y., Padoan R., Pagnoux C., Pan L., Panaritis K., Park J. K., Patel S., Patil P., Pazzola G., Peall A., Pearce F., Pehlevan S., Pereira L., Pettersson T., Pineau C. A., Pirila L., Poglodek B., Ponte C., Prieto-Gonzalez S., Priya S. R., Purewal B., Purschke S., Putaala J., Quickert S., Quincey V., Raghuvanshi S., Rajasekhar L., Ranganathan D., Rathi M., Rees D., Rees F., Renken U., Restuccia G., Rhee R. L., Rice B., Robins D., Robson J., Rodrigues M., Romao V. C., Rotar C., Ruediger C., Rutgers A., Sa A. C., Saavedra M. J., Sada K. -E., Sahbudin I., Salvarani C., Sandhu N., Santos E., Sato Y., Schafer V. S., Schiavon F., Schmidt W. A., Segelmark M., Shahin A., Sharma A., Shotton J., Silva C., Singer O. G., Sivasuthan G., Smolen S., Solanich-Moreno X., Boixader L. S., Song Y. W., Springer J., Sreih A. G., Srivastava R., Stamp L. K., Stevens R., Strbian D., Sugino K., Sunderkotter C., Suppiah R., Suzuki K., Szekanecz Z., Sznajd J., Taimen K., Tak P. P., Takeuchi T., Takizawa N., Tames L., Tan B. E., Tanaka M., Tang M. W., Tatlisumak T., Tesar V., Thomas A., Tian X., Tokunaga K., Tombetti E., Tomsic M., Toz B., Tsukamoto T., Uchida S., Unal A. U., Urban M. L., Usui J., Vaglio A., Venkatachalam S., Vermaak E., Viswanath V., Wada T., Wagh S., Wallace D. J., Walters G., Walz B., Wan J., Wang T., Wang G., Warrington K. J., Watts R. A., Wawrzycka-Adamczyk K., Weeratunga P., Weisman M. H., Wickramasinghe S., Williams M., Wojcik K., Woodruff L., Xenitidis T., Yamada H., Yamagata K., Yee C. -S., Yoon M., Yoshida K., Yoshifuji H., Ytterberg S. R., Yumura W., Zayed H., Zeng X., Zhao M. -H., Zugaj A., Zuk J. |
| المساهمون: | Monti, S., Craven, A., Klersy, C., Montecucco, C., Caporali, R., Watts, R., Merkel, P. A., Luqmani, R., Achilleos, K., Adler, M., Alba, M. A., Albert, D. A., Alibaz-Oner, F., Allcoat, P., Amano, K., Amarasuriya, M., Amudala, N. A., Andrews, J., Archer, A. M., Arimura, Y., Atukorala, I., Azevedo, E., Bajad, S., Baldwin, C., Barra, L. J., Baslund, B., Basu, N., Baykal, M., Berger, C., Berglin, E., Besada, E., Bhardwaj, M., Bischof, A., Blockmans, D., Blood, J., Draibe, J. B., Brand, S., Brandao, M., Bruce, I. N., Butler, A., Calabrese, L. H., Ferrer, D. C., Carette, S., Carmona, D., Ceunen, H., Chakravarty, K., Chapman, P. T., Chocova, Z., Chung, S. A., Ci, W., Cid, M. C., Clark, T. M., Clarkson, M. R., De Jesus Contreras-Rodriguez, F., Conway, R., Cooke, K., Viros, X. C., Cordeiro, A., Costa, A., Culfear, K., Daikeler, T., Danda, D., Das, S. K., Dasgupta, B., De Castro, A. M., Dehghan, N., Devassy, R., Dhindsa, N., Diamantopoulos, A. P., Direskeneli, H., Dobashi, H., Juan, D., Durrani, M., Edelsten, C., Eifert, J., Elhayek, S., Elsideeg, S., Endo, T., Erden, A., Erer, B., Eriksson, P., Erturk, Z., Espigol-Frigole, G., Felicetti, M., Ferraro, A., Ferro, J. M., Fifi-Mah, A., Flores-Suarez, L. F., Flossmann, O., Flynn, D., Fonseca, J. E., Foot, J., Foote, M., Forbess, L., Fujimoto, S., Fukuoka, K., Furtado, C., Furuta, S., Gaffo, A. L. |
| سنة النشر: | 2021 |
| المجموعة: | Archivio della ricerca dell'Università di Modena e Reggio Emilia (Unimore: IRIS) |
| مصطلحات موضوعية: | age, anti-neutrophil cytoplasmic antibody-associated vasculiti, outcome, Adolescent, Adult, Age of Onset, Aged, 80 and over, Antibodies, Antineutrophil Cytoplasmic, Female, Human, Male, Middle Aged, Morbidity, Prognosi, Retrospective Studie, Risk Assessment, Risk Factor, Survival Rate, United Kingdom, Young Adult |
| الوصف: | Objectives: ANCA-associated vasculitis (AAV) can affect all age groups. We aimed to show that differences in disease presentation and 6 month outcome between younger- A nd older-onset patients are still incompletely understood. Methods: We included patients enrolled in the Diagnostic and Classification Criteria for Primary Systemic Vasculitis (DCVAS) study between October 2010 and January 2017 with a diagnosis of AAV. We divided the population according to age at diagnosis: <65 years or ≥65 years. We adjusted associations for the type of AAV and the type of ANCA (anti-MPO, anti-PR3 or negative). Results: A total of 1338 patients with AAV were included: 66% had disease onset at <65 years of age [female 50%; mean age 48.4 years (s.d. 12.6)] and 34% had disease onset at ≥65 years [female 54%; mean age 73.6 years (s.d. 6)]. ANCA (MPO) positivity was more frequent in the older group (48% vs 27%; P = 0.001). Younger patients had higher rates of musculoskeletal, cutaneous and ENT manifestations compared with older patients. Systemic, neurologic,cardiovascular involvement and worsening renal function were more frequent in the older-onset group. Damage accrual, measured with the Vasculitis Damage Index (VDI), was significantly higher in older patients, 12% of whom had a 6 month VDI ≥5, compared with 7% of younger patients (P = 0.01). Older age was an independent risk factor for early death within 6 months from diagnosis [hazard ratio 2.06 (95% CI 1.07, 3.97); P = 0.03]. Conclusion: Within 6 months of diagnosis of AAV, patients >65 years of age display a different pattern of organ involvement and an increased risk of significant damage and mortality compared with younger patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/32447389; info:eu-repo/semantics/altIdentifier/wos/WOS:000765919200034; volume:60; issue:2; firstpage:617; lastpage:628; journal:RHEUMATOLOGY; http://hdl.handle.net/11380/1280544Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85090068067 |
| DOI: | 10.1093/rheumatology/keaa215 |
| الإتاحة: | https://doi.org/10.1093/rheumatology/keaa215Test http://hdl.handle.net/11380/1280544Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.894DCA24 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/rheumatology/keaa215 |
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