التفاصيل البيبلوغرافية
| العنوان: |
Benefits of Premaquick ® Combined Detection of IL-6/Total IGFBP-1/Native IGFBP-1 to Predict Preterm Delivery. |
| المؤلفون: |
Pambet, Mathilde, Sirodot, Fanny, Pereira, Bruno, Cahierc, Romain, Delabaere, Amélie, Comptour, Aurélie, Rouzaire, Marion, Sapin, Vincent, Gallot, Denis |
| المصدر: |
Journal of Clinical Medicine; Sep2023, Vol. 12 Issue 17, p5707, 11p |
| مصطلحات موضوعية: |
PREMATURE labor, CHILDBIRTH, UNIVERSITY hospitals, FIBRONECTINS, LONGITUDINAL method |
| مصطلحات جغرافية: |
CLERMONT-Ferrand (France) |
| مستخلص: |
We conducted a prospective double-blind study to compare two vaginal diagnostic methods in singleton pregnancies with threatened preterm labor (TPL) at the University Hospital of Clermont-Ferrand (France) from August 2018 to December 2020. Our main objective was to compare the diagnostic capacity at admission, in terms of positive predictive value (PPV) and negative predictive value (NPV), of Premaquick® (combined detection of IL-6/total IGFBP-1/native IGFBP-1) and QuikCheck fFN™ (fetal fibronectin) for delivery within 7 days in cases of TPL. We included 193 patients. Premaquick® had a sensitivity close to 89%, equivalent to QuikCheck fFN™, but a higher statistical specificity of 49.5% against 38.6% for QuikCheck fFN™. We found no superiority of Premaquick® over QuickCheck fFN™ in terms of PPV (6.6% vs. 7.9%), with NPV being equivalent in predicting childbirth within 7 days in cases of TPL (98.6% vs. 98.9%). Nevertheless, the combination of positive native and total IGFBP-1 and the combination of all three positive markers were associated with a higher PPV. Our results, though non-significant, support this combined multiple-biomarker approach to improve testing in terms of predictive values. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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