Enteric ganglioneuritis and abnormal interstitial cells of Cajal
| العنوان: | Enteric ganglioneuritis and abnormal interstitial cells of Cajal |
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| المؤلفون: | Stefan Lindgren, Béla Veress, Bodil Ohlsson, Göran Sundkvist |
| المصدر: | Inflammatory Bowel Diseases; 13, pp 721-726 (2007) |
| بيانات النشر: | Oxford University Press (OUP), 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Pathology, T-Lymphocytes, medicine.medical_treatment, interstitial cells of Cajal, irritable, Inflammatory bowel disease, Gastroenterology, Electrocardiography, Orthostatic vital signs, Heart Rate, Intestine, Small, autonomic nerve function tests, Immunology and Allergy, Medicine, Irritable bowel syndrome, Crohn's disease, Respiration, nervous system, Ganglia, Parasympathetic, Bowel resection, Middle Aged, Immunohistochemistry, Ulcerative colitis, symbols, Adult, medicine.medical_specialty, Posture, Coiled Bodies, dyspepsia, Gastroenterology and Hepatology, bowel syndrome, Diagnosis, Differential, symbols.namesake, Atrophy, Neuritis, Internal medicine, Humans, ganglioneuritis, ulcerative colitis, business.industry, enteric, Muscle, Smooth, Inflammatory Bowel Diseases, medicine.disease, Interstitial cell of Cajal, Exercise Test, business, Follow-Up Studies |
| الوصف: | Background: An increased prevalence of irritable bowel syndrome (IBS) and disturbances in cardiac and blood pressure reflexes have been described in patients with Crohn's disease (CD) and ulcerative colitis (UC). These features could be due to abnormalities in the gastrointestinal neurotransmission. The aims of this study were to examine whether histopathologic changes in the enteric nervous system correlate with disturbances in cardiac and blood pressure reflexes and the occurrence of IBS- and dyspepsia-like symptoms in these patients. Methods: Thirty patients with CD and UC with bowel resection were examined by deep-breathing and orthostatic tests. The resection specimens were evaluated histologically regarding visceral neuro- or myopathy. All medical records were studied for treatment and clinical course. Results: Ganglioneuritis was observed in 11 of 19 patients with CD and in 5 of 11 with UC. Only patients with CD had ganglioneuritis in the small intestine. Moreover, in CD the interstitial cells of Cajal (ICCs) in the small bowel showed atrophy and vacuolar degeneration, along with a reduced number of cells (P = 0.005). In UC the colonic ICCs were hyperplastic (P = 0.05) without signs of degeneration. The indices of deep-breathing and orthostatic tests were impaired, except in CD with ganglioneuritis, who showed normal test values. There were no correlations between histopathologic alterations versus IBS and dyspepsia. Conclusions: Visceral ganglioneuritis and pathologic ICCs were observed in patients with CD and UC. However, these histopathologic abnormalities could not be related to the clinical or autonomic features of the disease. |
| وصف الملف: | application/pdf |
| تدمد: | 1078-0998 1536-4844 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0eb579ac24a0d349c70f6e763755e03Test https://doi.org/10.1002/ibd.20095Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d0eb579ac24a0d349c70f6e763755e03 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10780998 15364844 |
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