التفاصيل البيبلوغرافية
| العنوان: |
Postoperative evaluation of olfactory dysfunction in eosinophilic chronic rhinosinusitis – comparison of histopathological and clinical findings. |
| المؤلفون: |
Kashiwagi, Takashi1 (AUTHOR), Tsunemi, Yasuhiro1 (AUTHOR), Akutsu, Makoto1 (AUTHOR), Nakajima, Itsuo1 (AUTHOR), Haruna, Shinichi1 (AUTHOR) haruna@dokkyomed.ac.jp |
| المصدر: |
Acta Oto-Laryngologica. Oct2019, Vol. 139 Issue 10, p881-889. 9p. |
| مصطلحات موضوعية: |
*PARANASAL sinus surgery, *CHRONIC diseases, *COMPUTED tomography, *ENDOSCOPY, *EOSINOPHILIA, *EOSINOPHILS, *EPITHELIAL cells, *HISTOLOGICAL techniques, *INFLAMMATION, *NERVE tissue proteins, *NEUROLOGIC examination, *NOSE, *POSTOPERATIVE period, *RESPIRATORY obstructions, *SINUSITIS, *SMELL disorders, *DISEASE relapse, *DISEASE complications, *DISEASE risk factors |
| الملخص (بالإنجليزية): |
Background: Olfactory dysfunction in eosinophilic chronic rhinosinusitis (ECRS) is poorly understood. Objective: To compare olfactory mucosal injury due to eosinophil infiltration in ECRS with postoperative olfactory function. Methods: Seventeen ECRS patients (ECRS group) and 18 bilateral rhinosinusitis (non-ECRS group) patients were compared. At 3 and 12 months post-endoscopic sinus surgery (ESS), all patients were evaluated for subjective symptoms (nasal obstruction, nasal discharge and olfactory dysfunction), endoscopic nasal findings, CT score and T&T olfactometer recognition threshold test. The eosinophil count, OMP-positive cells and epithelial erosion in olfactory mucosa collected during ESS were compared with the postoperative olfactory function. Results: The non-ECRS group showed significant improvement in all clinical findings at 3 and 12 months, but the ECRS group showed worsening of the olfactory dysfunction symptoms and T&T olfactometer recognition threshold at 12 months because of recurrence of sinusitis. The groups differed significantly in the ΔT&T value (i.e. pre-ESS T&T recognition threshold – post-ESS T&T recognition threshold) at both 3 and 12 months, and the degree of olfactory improvement differed. Histologically, the ECRS group showed significantly more eosinophils, fewer OMP-positive cells and greater epithelial erosion than the non-ECRS group. Conclusions: Eosinophilic inflammation was thought to cause olfactory mucosal injury/dysfunction. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): |
背景：嗜酸粒细胞性慢性鼻窦炎（ECRS）患者的嗅觉功能障碍尚不清楚。 目的：比较ECRS患者的嗜酸性粒细胞浸润致嗅粘膜损伤与术后嗅觉功能的关系。 方法：对17例（ECRS组）和18例（非ECRS组）双侧鼻窦炎患者进行比较。在鼻内镜鼻窦手术（ESS）后的3个月和12个月, 对所有患者的主观症状（鼻阻塞、鼻分泌物和嗅觉障碍）、鼻内镜检查结果、CT评分和T&T嗅觉仪识别阈值测试进行评估。比较ESS术中收集的嗅粘膜嗜酸性粒细胞计数、OMP阳性细胞和上皮糜烂与术后嗅觉功能的关系。 结果：非ECRS组在3个月和12个月时的所有临床表现均有明显改善, 但由于鼻窦炎复发, ECRS组在12个月时的嗅觉功能障碍症状和T&T嗅觉仪识别阈值均变得更糟。两组在3个月和12个月时的ΔT&T值（即ESS前T&T识别阈值-ESS后T&T识别阈值）有显著差异, 嗅觉改善程度也有差异。组织学上, ECRS组比非ECRS组表现出更多的嗜酸性粒细胞、更少的OMP阳性细胞和程度更大的上皮侵蚀。 结论：嗜酸性炎症被认为会导致嗅觉粘膜损伤或功能障碍 [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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