المؤلفون: Schrijver, Irene T., Théroude, Charlotte, Antonakos, Nikolaos, Regina, Jean, Le Roy, Didier, Bart, Pierre‐Alexandre, Chiche, Jean‐Daniel, Perreau, Matthieu, Pantaleo, Giuseppe, Calandra, Thierry, Roger, Thierry

المصدر: European Journal of Immunology; Oct2022, Vol. 52 Issue 10, p1676-1679, 4p

مصطلحات موضوعية: COVID-19 pandemic, MYELOID-derived suppressor cells, REGULATORY T cells, POST-acute COVID-19 syndrome, HEPATOCYTE growth factor

مستخلص: Severe COVID-19 patients had higher leukocyte counts and longer hospital stay than moderate COVID-19 patients (Supporting Information Table S1). COVID-19 rapidly increases MDSCs and prolongs innate immune dysfunctions We analyzed polymononuclear-MDSCs (PMN-MDSCs) and monocytic-MDSCs (M-MDSCs), the two main subgroups of MDSCs [1], in 56 COVID-19 patients analyzed at hospitalization and 21 patients analyzed 3 months later. Keywords: COVID-19; Cytokines; Dendritic cells; Monocytes; Myeloid-derived suppressor cells EN COVID-19 Cytokines Dendritic cells Monocytes Myeloid-derived suppressor cells 1676 1679 4 10/13/22 20221001 NES 221001 We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS and R848. [Extracted from the article]

: Copyright of European Journal of Immunology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Desgranges, Florian, Tadini, Eliana, Munting, Aline, Regina, Jean, Filippidis, Paraskevas, Viala, Benjamin, Karachalias, Eleftherios, Suttels, Véronique, Haefliger, David, Kampouri, Eleftheria, Van Singer, Mathias, Tschopp, Jonathan, Rochat Stettler, Laurence, Schaad, Siméon, Brahier, Thomas, Hugli, Olivier, Mueller, Yolanda, Gouveia, Alexandre, Opota, Onya, Carron, Pierre-Nicolas

المصدر: JGIM: Journal of General Internal Medicine; 2022 Supplement, Vol. 37, p1943-1952, 10p, 2 Diagrams, 3 Charts, 1 Graph

مستخلص: Background: After mild COVID-19, some outpatients experience persistent symptoms. However, data are scarce and prospective studies are urgently needed. Objectives: To characterize the post-COVID-19 syndrome after mild COVID-19 and identify predictors. Participants: Outpatients with symptoms suggestive of COVID-19 with (1) PCR-confirmed COVID-19 (COVID-positive) or (2) SARS-CoV-2 negative PCR (COVID-negative). Design: Monocentric cohort study with prospective phone interview between more than 3 months to 10 months after initial visit to the emergency department and outpatient clinics. Main Measures: Data of the initial visits were extracted from the electronic medical file. Predefined persistent symptoms were assessed through a structured phone interview. Associations between long-term symptoms and PCR results, as well as predictors of persistent symptoms among COVID-positive, were evaluated by multivariate logistic regression adjusted for age, gender, smoking, comorbidities, and timing of the survey. Key Results: The study population consisted of 418 COVID-positive and 89 COVID-negative patients, mostly young adults (median age of 41 versus 36 years in COVID-positive and COVID-negative, respectively; p = 0.020) and healthcare workers (67% versus 82%; p = 0.006). Median time between the initial visit and the phone survey was 150 days in COVID-positive and 242 days in COVID-negative patients. Persistent symptoms were reported by 223 (53%) COVID-positive and 33 (37%) COVID-negative patients (p = 0.006) and proportions were stable among the periods of the phone interviews. Overall, 21% COVID-positive and 15% COVID-negative patients (p = 0.182) attended care for this purpose. Four surveyed symptoms were independently associated with COVID-19: fatigue (adjusted odds ratio 2.14, 95% CI 1.04–4.41), smell/taste disorder (26.5, 3.46–202), dyspnea (2.81, 1.10–7.16), and memory impairment (5.71, 1.53–21.3). Among COVID-positive, female gender (1.67, 1.09–2.56) and overweight/obesity (1.67, 1.10–2.56) were predictors of persistent symptoms. Conclusions: More than half of COVID-positive outpatients report persistent symptoms up to 10 months after a mild disease. Only 4 of 14 symptoms were associated with COVID-19 status. The symptoms and predictors of the post-COVID-19 syndrome need further characterization as this condition places a significant burden on society. [ABSTRACT FROM AUTHOR]

: Copyright of JGIM: Journal of General Internal Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)