Longitudinal neuropsychological trajectories in idiopathic normal pressure hydrocephalus: a population-based study
العنوان: | Longitudinal neuropsychological trajectories in idiopathic normal pressure hydrocephalus: a population-based study |
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المؤلفون: | Lilja-Lund, Otto, Maripuu, Martin, Kockum, Karin, Andersson, Johanna, Lindam, Anna, Nyberg, Lars, Laurell, Katarina, 1967 |
المصدر: | BMC Geriatrics. 23 |
مصطلحات موضوعية: | Idiopathic normal pressure hydrocephalus, Ageing, Older adults, Cognition, Neuropsychology, Life-span, Cognitive development, Population-based |
الوصف: | Background: Idiopathic normal pressure hydrocephalus (iNPH) is a progressive syndrome affecting gait, incontinence, and cognition in a significant number of older adults. Still, prospective studies on early development of symptoms are scarce.Aim: To investigate how neuropsychological functions develop before and in already diagnosed iNPH over a two-year period in a population-based material.Method: A sample of 104 participants (median [IQR] 75 [72-80] years old) from the general population underwent CT-imaging and clinical assessment at baseline and follow-up. We used the iNPH symptom scale covering four domains (Neuropsychology, Gait, Balance, Incontinence) and additional tests of executive functions. Morphological signs were rated with the iNPH Radscale. Non-parametric statistics with Bonferroni corrections and a significance-level of p < 0.05 were used.Results: Median (IQR) time to follow-up was 25 (23-26) months. Effect size (ES) for individuals who developed iNPH (n = 8) showed a large (ES r = -0.55) decline in the Gait domain and on the Radscale (ES r = -0.60), with a medium deterioration in declarative memory (ES r = -0.37). Those having iNPH at baseline (n = 12) performed worse on one executive sub-function i.e., shifting (p = 0.045).Conclusion: Besides deterioration in gait and radiology, our results suggest that a neuropsychological trajectory for those developing iNPH includes a reduction in declarative memory. Executive dysfunction was limited to those already having iNPH at baseline. These findings could suggest that memory impairments are included in the early development of iNPH. |
وصف الملف: | electronic |
الوصول الحر: | https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-500134Test https://doi.org/10.1186/s12877-023-03747-yTest https://uu.diva-portal.org/smash/get/diva2:1750562/FULLTEXT01.pdfTest |
قاعدة البيانات: | SwePub |
تدمد: | 14712318 |
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DOI: | 10.1186/s12877-023-03747-y |