دورية أكاديمية
Biopolymer Extracted from Anadenanthera colubrina (Red Angico Gum) Exerts Therapeutic Potential in Mice: Antidiarrheal Activity and Safety Assessment
| العنوان: | Biopolymer Extracted from Anadenanthera colubrina (Red Angico Gum) Exerts Therapeutic Potential in Mice: Antidiarrheal Activity and Safety Assessment |
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| المؤلفون: | Thiago S. L. Araújo, Taiane M. de Oliveira, Nayara A. de Sousa, Luan K.M. Souza, Francisca B. M. Sousa, Ana P. de Oliveira, Lucas A. D. Nicolau, Alfredo A. V. da Silva, Alyne R. Araújo, Pedro J. C. Magalhães, Daniel F. P. Vasconcelos, Hugo R. de Jonge, Marcellus H. L. P. Souza, Durcilene A. Silva, Regina C. M. Paula, Jand Venes R. Medeiros |
| المصدر: | Pharmaceuticals, Vol 13, Iss 1, p 17 (2020) |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | polysaccharide, fabaceae, diarrhea, cholera, escherichia coli, Medicine, Pharmacy and materia medica, RS1-441 |
| الوصف: | Anadenanthera colubrina var. cebil (Griseb.) Altschul (Fabaceae family), commonly known as the red angico tree, is a medicinal plant found throughout Brazil’s semi-arid area. In this study, a chemical analysis was performed to investigate the antidiarrheal activity and safety profile of red angico gum (RAG), a biopolymer extracted from the trunk exudate of A. colubrina. Upon FT-IR spectroscopy, RAG showed bands in the regions of 1608 cm−1, 1368 cm−1, and 1029 cm−1, which relate to the vibration of O−H water molecules, deformation vibration of C-O bands, and vibration of the polysaccharide C-O band, respectively, all of which are relevant to glycosidic bonds. The peak molar mass of RAG was 1.89 × 105 g/mol, with the zeta potential indicating electronegativity. RAG demonstrated high yield and solubility with a low degree of impurity. Pre-treatment with RAG reduced the total diarrheal stool and enteropooling. RAG also enhanced Na+/K+-ATPase activity and reduced gastrointestinal transit, and thereby inhibited intestinal smooth muscle contractions. Enzyme-Linked Immunosorbent Assay (ELISA) demonstrated that RAG can interact with GM1 receptors and can also reduce E. coli-induced diarrhea in vivo. Moreover, RAG did not induce any signs of toxicity in mice. These results suggest that RAG is a possible candidate for the treatment of diarrheal diseases. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1424-8247 06444792 |
| العلاقة: | https://www.mdpi.com/1424-8247/13/1/17Test; https://doaj.org/toc/1424-8247Test |
| DOI: | 10.3390/ph13010017 |
| الوصول الحر: | https://doaj.org/article/2446b39e7c06444792ae74f6376bd6d5Test |
| رقم الانضمام: | edsdoj.2446b39e7c06444792ae74f6376bd6d5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14248247 06444792 |
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| DOI: | 10.3390/ph13010017 |