Facile surface functional polyetheretherketone with antibacterial and immunoregulatory activities for enhanced regeneration toward bacterium-infected bone destruction
| العنوان: | Facile surface functional polyetheretherketone with antibacterial and immunoregulatory activities for enhanced regeneration toward bacterium-infected bone destruction |
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| المؤلفون: | Jiyue Huang, Min Chen, Zhiqiang Xue, Shaohuang Weng, Lingling Huang, Xinhua Lin, An'an Sun, Xi Lin, Xinxin Bai |
| المصدر: | Drug Delivery, Vol 28, Iss 1, Pp 1649-1663 (2021) Drug Delivery article-version (VoR) Version of Record |
| بيانات النشر: | Taylor & Francis Group, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Staphylococcus aureus, Indoles, Polymers, Surface Properties, education, Pharmaceutical Science, Biocompatible Materials, RM1-950, enhanced osseintegration, Osseointegration, Cell Line, Microbiology, Rats, Sprague-Dawley, Benzophenones, Osteogenesis, Escherichia coli, medicine, Animals, Anti infectives, Cell Proliferation, anti-infection, Drug Implants, peek, biology, co-deposition of polydopamine and gentamicin, Chemistry, Osteomyelitis, Regeneration (biology), Cell Differentiation, General Medicine, immunoregulatory, Alkaline Phosphatase, medicine.disease, biology.organism_classification, Anti-Bacterial Agents, Rats, Drug Liberation, Therapeutics. Pharmacology, Gentamicins, Porosity, Bacteria, Research Article |
| الوصف: | Existing biologically inert or unmodified implants to treat infectious bone defects or osteomyelitis still cannot effectively solve bacterial infection and osseointegration. In this work, a simple co-deposition strategy was developed to modify porous polyetheretherketone (PEEK) with improved antibacterial activity and controllable immunoregulatory ability. After PEEK was treated by H2SO4 to obtain porous PEEK (SPEEK), the self-polymerization of dopamine was operated on SPEEK in the solution of dopamine and gentamicin sulfate (GS) to prepare polydopamine (pDA) and GS layer-modified SPEEK (labeled as SPEEK–pDA–GS). The morphology, surface property, and molecular structure of SPEEK–pDA–GS were investigated. Besides the antibacterial property of SPEEK–pDA–GS ascribed to the successful immobilization of GS, SPEEK–pDA–GS exhibited promoted osseointegration through the results of mineralization, alkaline phosphatase (ALP) levels and osteogenic gene expression. Furthermore, the evaluation of the cell proliferation suggested that SPEEK–pDA–GS possessed the biocompatibility and the immunoregulatory ability that induced macrophages to anti-inflammatory M2 phenotype. Using rat as model, in vivo results containing X-ray, μ-CT, immunohistochemistry, and pathological analysis showed the excellent healing effect of SPEEK–pDA–GS on bone defect with infection with biological safety. This work illustrates a new insight into the simple and effective modification of PEEK and other implants with antibacterial, immunoregulatory, and osseointegration abilities for clinical requirement. |
| اللغة: | English |
| تدمد: | 1521-0464 1071-7544 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2940fe9636c15e2be235dbff3db2ef5bTest https://doaj.org/article/4f84c524279e4555ae1e82e48c7db0a8Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2940fe9636c15e2be235dbff3db2ef5b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15210464 10717544 |
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