التفاصيل البيبلوغرافية
| العنوان: |
PLATELET SEROTONIN UPTAKE IS HIGHER IN EARLY-ONSET THAN IN LATE-ONSET ALCOHOLICS. |
| المؤلفون: |
JAVORS, MARTIN1,2, TIOURIRINE, MOHAMED1, PRIHODA, THOMAS1,3 |
| المصدر: |
Alcohol & Alcoholism. Jul2000, Vol. 35 Issue 4, p390-393. 4p. 1 Chart. |
| مصطلحات موضوعية: |
*SEROTONIN, *PEOPLE with alcoholism, *BLOOD platelets, *LYMPHOCYTES, *PHYSIOLOGICAL effects of alcohol |
| مستخلص: |
The main objective of this study was to compare platelet serotonin (5-HT) uptake between early-onset alcoholics (EOA) and late-onset alcoholics (LOA). Subjects were 24 dependent male alcoholic in-patients and 21 healthy control subjects. 5-HT uptake was quantified by incubating platelets with [3H]5-HT at various concentrations (0.5 to 1000 nM). 5-HT uptake was higher in EOA, compared to both the LOA and control groups (P < 0.02) at the highest 5-HT concentration (1000 nM). No significant difference was found between LOA and controls or between EOA + LOA and controls. Previous studies have shown that 5-HT uptake was higher in platelets, lymphocytes, and brain of alcoholics vs controls, but our data suggest that higher platelet serotonin transporter function is limited to EOA, not LOA. [ABSTRACT FROM PUBLISHER] |
| قاعدة البيانات: |
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