التفاصيل البيبلوغرافية
| العنوان: |
Placental autophagy failure: A risk factor for preeclampsia. |
| المؤلفون: |
Nakashima, Akitoshi, Shima, Tomoko, Aoki, Aiko, Kawaguchi, Mihoko, Yasuda, Ippei, Tsuda, Sayaka, Yoneda, Satoshi, Yamaki‐Ushijima, Akemi, Cheng, Shibin, Sharma, Surendra, Saito, Shigeru |
| المصدر: |
Journal of Obstetrics & Gynaecology Research; Dec2020, Vol. 46 Issue 12, p2497-2504, 8p |
| مصطلحات موضوعية: |
RISK factors of preeclampsia, AUTOPHAGY, PHYSIOLOGICAL adaptation, HOMEOSTASIS, IMMUNITY, MATERNAL mortality, PLACENTA, PREECLAMPSIA, PHYSIOLOGICAL stress, FETAL development |
| مستخلص: |
Hypertensive disorders of pregnancy, including preeclampsia, directly affect maternal and perinatal morbidity and mortality. As the pathophysiology of preeclampsia is multi‐factorial and has been studied using different approaches, we have demonstrated that impaired autophagy is an intertwined risk factor for preeclampsia. This concept has been verified in both in vitro and in vivo experiments. Autophagy is primarily involved in maintaining cellular homeostasis, and in immune regulation, longevity, cytokines secretion and a variety of other biological functions. Here, we review the role of autophagy in normal embryogenesis and placentation. Once placental autophagy is impaired by metabolic stress such as hypoxia, endoplasmic reticulum stress or starvation, placental development could be disrupted, resulting in functional maladaptations at the maternal‐fetal interface. These malfunctions may result in fetal growth restriction or preeclampsia. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
