دورية أكاديمية
DEM based investigation of powder packing in 3D printing of pharmaceutical tablets
| العنوان: | DEM based investigation of powder packing in 3D printing of pharmaceutical tablets |
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| المؤلفون: | Sen Koyel, Mehta Tanu, W.K.Ma Anson, Chaudhuri Bodhisattwa |
| المصدر: | EPJ Web of Conferences, Vol 249, p 14012 (2021) |
| بيانات النشر: | EDP Sciences |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Physics, QC1-999 |
| الوصف: | 3D printing is emerging as one of the most promising methods to manufacture Pharmaceutical dosage forms as it offers multiple advantages such as personalization of dosage forms, polypill, fabrication of complex dosage forms etc. 3D printing came into existence in 1980s but its use was extended recently to pharmaceutical industry along with the approval of first 3D printed tablet Spritam by FDA in 2015. Spritam was manufactured by Aprecia pharmaceuticals using binder jetting technology. Binder jet 3D printing involves a hopper for powder discharge and printheads for ink jetting. The properties of tablets are highly dependent upon the discharge quality of powder mixture from the hopper and jetting of the ink/binder solution from the printhead nozzle. In this study, numerical models were developed using Discrete element method (DEM) to gain better understanding of the binder jet 3D printing process. The DEM modeling of hopper discharge was performed using in-house DEM code to study the effect of raw material attributes such as powder bed packing density (i.e. particle size, particle density etc) on the printing process, especially during powder bed preparation. This DEM model was further validated experimentally, and the model demonstrated good agreement with experimental results. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2100-014X |
| العلاقة: | https://www.epj-conferences.org/articles/epjconf/pdf/2021/03/epjconf_pg2021_14012.pdfTest; https://doaj.org/toc/2100-014XTest; https://doaj.org/article/79113a28e99144a8b2cffbfa9e5a5038Test |
| DOI: | 10.1051/epjconf/202124914012 |
| الإتاحة: | https://doi.org/10.1051/epjconf/202124914012Test https://doaj.org/article/79113a28e99144a8b2cffbfa9e5a5038Test |
| رقم الانضمام: | edsbas.2E2036FF |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 2100014X |
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| DOI: | 10.1051/epjconf/202124914012 |