المؤلفون: Naida Babić, Serkan Dogan, Jasmina Čakar, Amela Pilav, Damir Marjanović, Vesna Hadžiavdić

المصدر: Annals of Human Biology, Vol 44, Iss 5, Pp 419-426 (2017)

مصطلحات موضوعية: y-str, powerplex y23, bosnia and herzegovina, phylogeny, population genetics, Biology (General), QH301-705.5, Human anatomy, QM1-695, Physiology, QP1-981

الوصف: Background: Tuzla Canton is the most populated region in the ethnically mixed territory of Bosnia and Herzegovina, whose genetic analysis could provide an insight into past demographic events. Aim: Analysis of 23 Y-chromosome STR markers in the population of Tuzla Canton and investigation of the genetic relationship of the male population of the Tuzla Canton and that of the larger Bosnian and Herzegovinian population as well as neighbouring and other European populations. Subjects and methods: The study was conducted among 100 unrelated healthy adult males from Tuzla Canton that have been genotyped using 23 Y-STR loci included in the PowerPlex Y23 kit. Statistical parameters such as haplotype diversity and allele frequencies were calculated, as well as the Rst-based genetic distances between the new dataset and those from Bosnia and Herzegovina and elsewhere, which were then visualised through multi-dimensional scaling plot and neighbour-joining phylogenetic tree analyses. Results: The PowerPlex Y23 kit has shown high discrimination capacity, as all 100 individuals have unique haplotypes. The newly incorporated loci seem to be highly informative. Population comparison reveals no statistically significant differences between the study population and the general Bosnian-Herzegovinian population, and between the study population and neighbouring populations. Conclusion: These results could be used as an additional investigation of the genetic relationship between the regional populations in Bosnia and Herzegovina and neighbouring human populations, as well as for further human population and forensic genetics studies.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/0301-4460Test; https://doaj.org/toc/1464-5033Test

الوصول الحر: https://doaj.org/article/a6b08fea92954932beaeac57b859bf34Test

المؤلفون: Teufik Goletic, Rijad Konjhodzic, Nihad Fejzic, Sejla Goletic, Toni Eterovic, Adis Softic, Aida Kustura, Lana Salihefendic, Maja Ostojic, Maja Travar, Visnja Mrdjen, Nijaz Tihic, Sead Jazic, Sanjin Musa, Damir Marjanovic, Mirsada Hukic

المصدر: Bosnian Journal of Basic Medical Sciences (2021)

مصطلحات موضوعية: COVID-19, SARS-CoV-2, whole genome sequencing, Viral infections, Nanopore sequencing, phylogeny, Medicine (General), R5-920

الوصف: This is the first report of molecular and epidemiology findings from Bosnia and Herzegovina related to ongoing SARS-CoV-2 epidemic. Whole Genome Sequence of four samples from COVID-19 outbreaks was done in two laboratories in Bosnia and Herzegovina (Veterinary Faculty Sarajevo and Alea Genetic Center). All four BiH sequences cluster mainly with European ones (Italy, Austria, France, Sweden, Cyprus, England). The constructed phylogenetic tree indicates possible multiple independent introduction events. The data presented contributes to a better understanding of COVID-19 in the current reemergence of the disease.

العلاقة: https://www.bjbms.org/ojs/index.php/bjbms/article/view/5381Test; https://doaj.org/toc/1512-8601Test; https://doaj.org/toc/1840-4812Test; https://doaj.org/article/dfa43b46fbc64802b7e61f44e179a335Test

الإتاحة: https://doi.org/10.17305/bjbms.2020.5381Test
https://doaj.org/article/dfa43b46fbc64802b7e61f44e179a335Test

المؤلفون: Nijaz Tihic, Aida Kustura, Visnja Mrdjen, Maja Ostojić, Sead Jazic, Lana Salihefendić, Nihad Fejzic, Mirsada Hukić, Rijad Konjhodzic, Sanjin Musa, Toni Eterović, Damir Marjanović, Sejla Goletic, Maja Travar, Teufik Goletić, Adis Softic

المصدر: Bosnian Journal of Basic Medical Sciences (2021)
Bosnian Journal of Basic Medical Sciences

مصطلحات موضوعية: 2019-20 coronavirus outbreak, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Nanopore sequencing, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Population, Disease cluster, phylogeny, Epidemiology, medicine, Humans, education, Socioeconomics, Bosnia and Herzegovina, education.field_of_study, whole genome sequencing, Viral infections, lcsh:R5-920, Phylogenetic tree, business.industry, SARS-CoV-2, Outbreak, COVID-19, General Medicine, Genealogy, Geography, Phylogenetic Pattern, business, lcsh:Medicine (General), Research Article

الوصف: This is the first report of molecular and epidemiology findings from Bosnia and Herzegovina related to ongoing severe acute respiratory syndrome coronavirus 2 epidemic. Whole genome sequence of four samples from coronavirus disease 2019 (COVID-19) outbreaks was done in two laboratories in Bosnia and Herzegovina (Veterinary Faculty Sarajevo and Alea Genetic Center). All four BiH sequences cluster mainly with European ones (Italy, Austria, France, Sweden, Cyprus, and England). The constructed phylogenetic tree indicates possible multiple independent introduction events. The data presented contribute to a better understanding of COVID-19 in the current reemergence of the disease.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6a8251967f55f06792c4028c90e192Test
https://www.bjbms.org/ojs/index.php/bjbms/article/view/5381Test

المؤلفون: Ramazan Tunc, Cemal Gurkan, Serkan Dogan, Nihad Ahmed Ameen, Damir Marjanović, Mustafa Dogan, Damla Kanliada Demirdov, Hasan Emin Balkaya

المصدر: PLoS ONE, Vol 12, Iss 11, p e0187408 (2017)
PLoS ONE

مصطلحات موضوعية: 0301 basic medicine, Male, Heredity, Arabic People, Ethnic group, lcsh:Medicine, 030105 genetics & heredity, Iran, Haplogroup, Geographical Locations, Ethnicity, Sumerian, Ethnicities, lcsh:Science, Phylogeny, education.field_of_study, Multidisciplinary, Middle East, Ecology, Mosaicism, Turkey (Country), Genealogy, Europe, Genetic Mapping, Geography, Iraq, language, Research Article, Asia, Ecological Metrics, Population, Context (language use), 03 medical and health sciences, Molecular anthropology, Mesopotamia, Kurdish People, Genetics, Humans, Northern Iraqi Arabs, Kurds, Syriacs, Turkmens and Yazidis, Y chromosome, haplogroup, education, Evolutionary Biology, Chromosomes, Human, Y, Population Biology, Ecology and Environmental Sciences, lcsh:R, Biology and Life Sciences, Species Diversity, language.human_language, 030104 developmental biology, Haplotypes, People and Places, Haplogroups, Population Groupings, lcsh:Q, Population Genetics, Microsatellite Repeats

الوصف: Widely considered as one of the cradles of human civilization, Mesopotamia is largely situated in the Republic of Iraq, which is also the birthplace of the Sumerian, Akkadian, Assyrian and Babylonian civilizations. These lands were subsequently ruled by the Persians, Greeks, Romans, Arabs, Mongolians, Ottomans and finally British prior to the independence. As a direct consequence of this rich history, the contemporary Iraqi population comprises a true mosaic of different ethnicities, which includes Arabs, Kurds, Turkmens, Assyrians, and Yazidis among others. As such, the genetics of the contemporary Iraqi populations are of anthropological and forensic interest. In an effort to contribute to a better understanding of the genetic basis of this ethnic diversity, a total of 500 samples were collected from Northern Iraqi volunteers belonging to five major ethnic groups, namely: Arabs (n = 102), Kurds (n = 104), Turkmens (n = 102), Yazidis (n = 106) and Syriacs (n = 86). 17-loci Y-STR analyses were carried out using the AmpFlSTR Yfiler system, and subsequently in silico haplogroup assignments were made to gain insights from a molecular anthropology perspective. Systematic comparisons of the paternal lineages of these five Northern Iraqi ethnic groups, not only among themselves but also in the context of the larger genetic landscape of the Near East and beyond, were then made through the use of two different genetic distance metric measures and the associated data visualization methods. Taken together, results from the current study suggested the presence of intricate Y- chromosomal lineage patterns among the five ethic groups analyzed, wherein both interconnectivity and independent microvariation were observed in parallel, albeit in a differential manner. Notably, the novel Y-STR data on Turkmens, Syriacs and Yazidis from Northern Iraq constitute the first of its kind in the literature. Data presented herein is expected to contribute to further population and forensic investigations in Northern Iraq in particular and the Near East in general.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef667f5c8a2d97108f19f6d20e729661Test
http://europepmc.org/articles/PMC5669434?pdf=renderTest

المؤلفون: Sardana A. Fedorova, Ene Metspalu, Anne-Mai Ilumäe, Siiri Rootsi, Lisenka E.L.M. Vissers, François-Xavier Ricaut, Tatiana M. Karafet, David M. Lambert, Richard Villems, Elza Khusnutdinova, Denis Pierron, Daria V. Lichman, Pradiptajati Kusuma, Shahlo Turdikulova, Alena Kushniarevich, Boris Malyarchuk, Anders Eriksson, Bayazit Yunusbayev, Olga Utevska, Ludmila P. Osipova, Christina A. Eichstaedt, Monika Karmin, S. S. Litvinov, Knut Johnsen, Joseph Wee Tien Seng, Reedik Mägi, Alexia Cardona, Oleg Balanovsky, Dragan Primorac, Dilbar Dalimova, Pagbajabyn Nymadawa, Krishna R. Veeramah, Andrea Manica, Rita Khusainova, I. M. Khidiyatova, Michael F. Hammer, Kuvat T. Momynaliev, Sarah A. Tishkoff, Toomas Kivisild, Michael C. Westaway, Zhaxylyk Sabitov, Tarmo Puurand, S M Abdullah, Lejla Kovacevic, Levon Yepiskoposyan, Chris Tyler-Smith, Mario Mitt, Rane Willerslev, Mark G. Thomas, Qasim Ayub, Gazi Nurun Nahar Sultana, Jainagul Isakova, Christian Gilissen, Kristiina Tambets, Craig Muller, Gyaneshwer Chaubey, Thorfinn Sand Korneliussen, Miroslava Derenko, Farida Akhatova, V. L. Akhmetova, Joris A. Veltman, Ulvi Gerst Talas, Hovhannes Sahakyan, Maru Mormina, L. A. Atramentova, Andrea Bamberg Migliano, Vedrana Škaro, Georgi Hudjashov, N. N. Trofimova, Rasmus Nielsen, Mari Järve, Luca Pagani, George Andriadze, Evelin Mihailov, Lauri Saag, Michael DeGiorgio, Mikk Eelmets, Harilanto Razafindrazaka, Irina Evseeva, Murray P. Cox, Elvira Pocheshkhova, Nikolay A. Barashkov, Eva Liis Loogväli, Neil Bradman, Joseph Lachance, Grigor Zoraqi, Eske Willerslev, Melissa A. Wilson Sayres, Elena Balanovska, Fernando L. Mendez, Peter A. Underhill, Doron M. Behar, Mário Vicente, Maido Remm, Mait Metspalu, Yali Xue, Florian Clemente, Andres Metspalu, Zuzana Faltyskova, Damir Marjanović

المساهمون: Dept Evolutionary Biol, University of Tartu, Leverhulme Centre for Human Evolutionary Studies University of Cambridge, University of Cambridge [UK] (CAM), Human Evolution, The Wellcome Trust Sanger Institute [Cambridge], University of Pennsylvania, Human Genetics, Centre National de la Recherche Scientifique (CNRS), Anthropologie Moléculaire et Imagerie de Synthèse (AMIS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU), Environmental Futures Research Institute, Griffith University [Brisbane], Institute of Molecular Biology and Medicine, International Network for the Sequencing of resPIRratory vIrusEs (INSPIRE), Department of Oncology, Radboud University Medical Center [Nijmegen], The Estonian Genome Center, Swedish Institute of Space Physics [Uppsala] (IRF), Marketing Department, Institute of Cytology and Genetics, Russian Academy of Sciences [Moscow] (RAS), Russian Academy of Medical Sciences, Institute of Biochemistry and Genetics [Bashkortostan Republic, Russia], Russian Academy of Sciences / Ufa Scientific Centre [Bashkortostan Republic, Russia]], Wellcome Trust Genome Campus, Department of Psychiatry and Behavioral Sciences [Stanford], Stanford Medicine, Stanford University-Stanford University, Section for GeoGenetics, Globe Institute, Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH)-Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), Dept Integrat Biol, UMR 6578 : Anthropologie Bio-Culturelle (UAABC), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Université Tartu, University of Pennsylvania [Philadelphia], Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU)-Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU)

المصدر: Genome Research
Genome Research, 2015, 25 (4), pp.459-466. ⟨10.1101/gr.186684.114⟩
Genome Research, Cold Spring Harbor Laboratory Press, 2015, 25 (4), pp.459-466. ⟨10.1101/gr.186684.114⟩
Monika, K, Saag, L, Vicente, M, A. Wilson Sayres, M, Järve, M, Talas, U G, Rootsi, S, Ilumäe, A-M, Mägi, R, Pagani, L, Puurand, T, Faltyskova, Z, Clemente, F, Cardona, A, Metspalu, E, Sahakyan, H, Yunusbayev, B, Hudjashov, G, DeGiorgio, M, Loogväli, E-L, Eichstaedt, C, Eelmets, M, Chaubey, G, Tambets, K, Litvinov, S, Mormina, M, Xue, Y, Ayub, Q, Zoraqi, G, Sand Korneliussen, T, Akhatova, F, Lachance, J, Tishkoff, S, Momynaliev, K, Ricaut, F-X, Kusuma, P, Razafindrazaka, H, Pierron, D, Cox, M P, Sultana, G N N, Willerslev, R, Muller, C, Westaway, M, Lambert, D, Skaro, V, Kovačevic, L, Turdikulova, S, Dalimova, D, Khusainova, R, Trofimova, N, Akhmetova, V, Khidiyatova, I, Lichman, D V, Isakova, J, Pocheshkhova, E, Sabitov, Z, Barashkov, N A, Nymadawa, P, Mihailov, E, Seng, J W T, Evseeva, I, Migliano, A B, Abdullah, S, Andriadze, G, Primorac, D, Atramentova, L, Utevska, O, Yepiskoposyan, L, Marjanovic, D, Kushniarevich, A, Behar, D M, Gilissen, C, Vissers, L, Veltman, J A, Balanovska, E, Derenko, M, Malyarchuk, B, Metspalu, A, Fedorova, S, Eriksson, A, Manica, A, Mendez, F L, Karafet, T M, Veeramah, K R, Bradman, N, Hammer, M F, Osipova, L P, Balanovsky, O, Khusnutdinova, E K, Johnsen, K, Remm, M, Thomas, M G, Tyler-Smith, C, Underhill, P A, Willerslev, E, Nielsen, R, Metspalu, M, Villems, R & Kivisild, T 2015, ' A recent bottleneck of Y chromosome diversity coincides with a global change in culture ', Genome Research, vol. 25, pp. 459-466 . https://doi.org/10.1101/gr.186684.114Test
Genome Research, 25, 459-66
Genome Research, 25, 4, pp. 459-66

مصطلحات موضوعية: Male, Most recent common ancestor, Population, [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, bottleneck, Y chromosome diversity, global change in culture, Human genetic variation, Biology, DNA, Mitochondrial, Haplogroup, Bottleneck, Evolution, Molecular, 03 medical and health sciences, Genetics, Humans, education, Phylogeny, Genetics (clinical), 030304 developmental biology, 0303 health sciences, education.field_of_study, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], Chromosomes, Human, Y, Base Sequence, Models, Genetic, Research, Racial Groups, 030305 genetics & heredity, Haplotype, Genetic Variation, Sequence Analysis, DNA, Genetics, Population, Ancient DNA, Haplotypes, Evolutionary biology, Biological dispersal

الوصف: It is commonly thought that human genetic diversity in non-African populations was primarily shaped by a recent out-of-Africa dispersal. Here we present a large geographical Y chromosome study using 459 high coverage sequences, including 302 newly reported here. We date the Y chromosomal Most Recent Common Ancestor (MRCA) in Africa at 254 (95% CI 192- 307) kya and differentiation of African and non-African lineages 52-121 kya. The age estimates for major non-African founder haplogroups cluster closely in a narrow time interval at 47-52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. We find that the highest basal Y chromosome diversity outside Africa has been preserved in South and Southeast Asians while extant Y chromosome diversity in Europe and the Near East stems from a small number of mid-Holocene founders. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck, followed by a fast recovery in Old World populations dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b746928f07f537c090583c6863446a4Test
https://hal.science/hal-02112784/documentTest

المؤلفون: Jelena, Sarac, Tena, Sarić, Dubravka Havaš, Auguštin, Nina, Jeran, Lejla, Kovačević, Svjetlana, Cvjetan, Ana Perinić, Lewis, Ene, Metspalu, Maere, Reidla, Natalija, Novokmet, Maruška, Vidovič, Branimir, Nevajda, Anton, Glasnović, Damir, Marjanović, Saša, Missoni, Richard, Villems, Pavao, Rudan

المصدر: Annals of human genetics. 78(3)

مصطلحات موضوعية: Gene Flow, Analysis of Variance, Base Sequence, Genotype, Haplotypes, Molecular Sequence Data, Yugoslavia, Genetic Variation, Humans, Sequence Analysis, DNA, DNA, Mitochondrial, Polymerase Chain Reaction, Phylogeny

الوصف: High mtDNA variation in Southeastern Europe (SEE) is a reflection of the turbulent and complex demographic history of this area, influenced by gene flow from various parts of Eurasia and a long history of intermixing. Our results of 1035 samples (488 from Croatia, 239 from Bosnia and 130 from Herzegovina, reported earlier, and 97 Slovenians and 81 individuals from Žumberak, reported here for the first time) show that the SEE maternal genetic diversity fits within a broader European maternal genetic landscape. The study also shows that the population of Žumberak, located in the continental part of Croatia, developed some unique mtDNA haplotypes and elevated haplogroup frequencies due to distinctive demographic history and can be considered a moderate genetic isolate. We also report seven samples from the Bosnian population and one Herzegovinian sample designated as X2* individuals that could not be assigned to any of its sublineages (X2a'o) according to the existing X2 phylogeny. In an attempt to clarify the phylogeny of our X2 samples, their mitochondrial DNA has been completely sequenced. We suppose that these lineages are signs of local microdifferentiation processes that occurred in the recent demographic past in this area and could possibly be marked as SEE-specific X2 sublineages.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::798e20ebcd7abac23a14ab5451905b83Test
https://pubmed.ncbi.nlm.nih.gov/24621318Test

المؤلفون: Serkan, Dogan, Lejla, Kovacević, Damir, Marjanović

المصدر: Collegium antropologicum
Volume 37
Issue 4

مصطلحات موضوعية: Bosnia and Herzegovina, Polymorphism, Genetic, STR loci, allele frequencies, DNA typing, Turkish population data, polymorphisms, phylogenetic tree, Turkey, Humans, Polymerase Chain Reaction, Phylogeny, Microsatellite Repeats

الوصف: Allele frequencies of 15 STRs included in the PowerPlex 16 System (D3S1358, TH01, D21S11, D18S51, Penta E, D5S818, D13S317, D7S820, D16S539, CSF1PO, Penta D, VWA, D8S1179, TPOX and FGA) were calculated from the referent sample of 100 unrelated individuals of both sexes from Turkish student population living in Sarajevo, Bosnia and Herzegovina. Buccal swab, as a source of DNA, was collected from the volunteers from whom the informed consent form was obtained. DNA extraction was performed using QIAamp DNA Micro kit by Qiagen. DNA template ranging from 0.5 to 2 ng was used to amplify 15 STR loci by PCR multiplex amplification which was performed by using the PowerPlex 16 kit (Promega Corp., Madison, WI, USA) according to the manufacturer’s protocol. The amplifications were carried out in a PE Gene Amp PCR System thermal cycler (Applied Biosystems) and capillary electrophoresis was car- ried out in an ABI PRISM 310 Genetic Analyzer (Applied Biosystems) in accordance with the manufacturer’s recommen- dations. The frequency of each locus was calculated from the numbers of each observed genotype. Deviation from Hardy- -Weinberg equilibrium and observed heterozygosity were calculated. Data were analyzed by using Microsoft Excel work- book template – Powerstats V12 and the power of discrimination (PD), power of exclusion (PE), as well as other popula- tion genetic indices for the 15 STR loci were calculated. Obtained results contribute to existing Turkish DNA database, as well as insight of differences and similarities in comparison to population of Bosnia and Herzegovina. In addition, 13 autosomal STR loci frequencies (D3S1358, TH01, D21S1 1, D18S51, Penta E, D5S818, D13S317, D7S820, D16S539, CSFIPO, Penta D, VWA, D8S1 179, TPOX, and FGA) were studied in 15 different worldwide populations (Turkish, Bosnian, Croatian, Serbian, Montenegrin, Macedonian, Albanian, Kosovan, Greek, Russian, Japanese, Korean, Lithua- nian, Iraqi, Belarusian). For the proof of corresponding data, two different Turkish population STR data obtained from previously published articles were compared with our data and this showed that our data correspond to these 2 previ- ously published data. Further, STR allele frequency data for 13 loci for each population were obtained from previous sci- entific articles and the allele frequencies and genetic diversity among the 15 sample populations were compared. In addi- tion, even though the populations are from different nationalities, the STR data are similar among the geographically close populations. The phylogenetic tree established among worldwide populations and genetic distance values show a great affinity among the 15 populations. Our data is useful for anthropological and further comparative genetic studies of populations.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a1ed55ab84c5e78b7fc7294f2bd3735bTest
https://www.bib.irb.hr/756563Test

المؤلفون: Stojko Vidović, Peter A. Underhill, Dragan Primorac, Simona Fornarino, Katia Drobnic, Ornella Semino, Vincenza Battaglia, Natalie M. Myres, Naser Durmishi, Maria Pala, Antonio Torroni, Nadia Al-Zahery, A. Silvana Santachiara-Benerecetti, Roy J. King, Damir Marjanović, Siiri Rootsi, Anna Olivieri, Rifat Hadziselimovic

المصدر: European Journal of Human Genetics. 17:853-853

مصطلحات موضوعية: Genetic Markers, Male, Range (biology), Population, Biology, Haplogroup, Article, Prehistory, Africa, Northern, Cultural Evolution, Balkan Neolithic/Farming transition, Peopling of Europe, Y-chromosome haplogroups, Genetics, Humans, Economic geography, Diffusion (business), education, Holocene, Mesolithic, Phylogeny, Genetics (clinical), education.field_of_study, Middle East, Chromosomes, Human, Y, Geography, business.industry, Genetic Variation, Agriculture, Human genetics, Europe, Genetics, Population, Ethnology, Erratum, business, Microsatellite Repeats

الوصف: The debate concerning the mechanisms underlying the prehistoric spread of farming to Southeast Europe is framed around the opposing roles of population movement and cultural diffusion. To investigate the possible involvement of local people during the transition of agriculture in the Balkans, we analysed patterns of Y-chromosome diversity in 1206 subjects from 17 population samples, mainly from Southeast Europe. Evidence from three Y-chromosome lineages, I-M423, E-V13 and J-M241, make it possible to distinguish between Holocene Mesolithic forager and subsequent Neolithic range expansions from the eastern Sahara and the Near East, respectively. In particular, whereas the Balkan microsatellite variation associated to J-M241 correlates with the Neolithic period, those related to E-V13 and I-M423 Balkan Y chromosomes are consistent with a late Mesolithic time frame. In addition, the low frequency and variance associated to I-M423 and E-V13 in Anatolia and the Middle East, support an European Mesolithic origin of these two clades. Thus, these Balkan Mesolithic foragers with their own autochthonous genetic signatures, were destined to become the earliest to adopt farming, when it was subsequently introduced by a cadre of migrating farmers from the Near East. These initial local converted farmers became the principal agents spreading this economy using maritime leapfrog colonization strategies in the Adriatic and transmitting the Neolithic cultural package to other adjacent Mesolithic populations. The ensuing range expansions of E-V13 and I-M423 parallel in space and time the diffusion of Neolithic Impressed Ware, thereby supporting a case of cultural diffusion using genetic evidence.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822919dd8e49c0878b1b333707caaef1Test
https://doi.org/10.1038/ejhg.2009.21Test

المؤلفون: Alena Kushniarevich, Olga Utevska, Marina Chuhryaeva, Anastasia Agdzhoyan, Khadizhat Dibirova, Ingrida Uktveryte, Märt Möls, Lejla Mulahasanovic, Andrey Pshenichnov, Svetlana Frolova, Andrey Shanko, Ene Metspalu, Maere Reidla, Kristiina Tambets, Erika Tamm, Sergey Koshel, Valery Zaporozhchenko, Lubov Atramentova, Vaidutis Kučinskas, Oleg Davydenko, Olga Goncharova, Irina Evseeva, Michail Churnosov, Elvira Pocheshchova, Bayazit Yunusbayev, Elza Khusnutdinova, Damir Marjanović, Pavao Rudan, Siiri Rootsi, Nick Yankovsky, Phillip Endicott, Alexei Kassian, Anna Dybo, Genographic Consortium, Chris Tyler-Smith, Elena Balanovska, Mait Metspalu, Toomas Kivisild, Richard Villems, Oleg Balanovsky

المصدر: Recercat. Dipósit de la Recerca de Catalunya
instname
PLoS ONE, Vol 10, Iss 9, p e0135820 (2015)
PLoS ONE, San Francisko : Public Library of Science, 2015, Vol. 10, iss. 9, Art. no. e0135820
PLoS ONE

مصطلحات موضوعية: Mitochondrial DNA, Population genetics, lcsh:Medicine, Context (language use), Biology, DNA, Mitochondrial, Polymorphism, Single Nucleotide, Language geography, White People, 03 medical and health sciences, Genetic variation, Humans, Slavic languages, genetic heritage, mtDNA, Y chromosome, lcsh:Science, Phylogeny, Language, 030304 developmental biology, Genetics, Balto-Slavic, linguists, mitochondrial DNA, Y-chromosome, SNP, 0303 health sciences, Genetic diversity, Chromosomes, Human, Y, Multidisciplinary, 030305 genetics & heredity, lcsh:R, Genetic Variation, Gene Pool, Linguistic geography, Slavs, Europe, Phylogeography, Sociolinguistics, Evolutionary biology, Languages, lcsh:Q, Gene pool, Research Article

الوصف: The Slavic branch of the Balto-Slavic sub- family of Indo-European languages underwent rapid divergence as a result of the spatial expansion of its speakers from Central-East Europe, in early medieval times. This expansion–mainly to East Europe and the northern Balkans–resulted in the incorporation of genetic components from numerous autochthonous populations into the Slavic gene pools. Here, we characterize genetic variation in all extant ethnic groups speaking Balto- Slavic languages by analyzing mitochondrial DNA (n = 6, 876), Y-chromosomes (n = 6, 079) and genome-wide SNP profiles (n = 296), within the context of other European populations. We also reassess the phylogeny of Slavic languages within the Balto-Slavic branch of Indo- European. We find that genetic distances among Balto-Slavic populations, based on autosomal and Y-chromosomal loci, show a high correlation (0.9) both with each other and with geography, but a slightly lower correlation (0.7) with mitochondrial DNA and linguistic affiliation. The data suggest that genetic diversity of the present-day Slavs was predominantly shaped in situ, and we detect two different substrata: ‘central-east European’ for West and East Slavs, and ‘south-east European’ for South Slavs. A pattern of distribution of segments identical by descent between groups of East- West and South Slavs suggests shared ancestry or a modest gene flow between those two groups, which might derive from the historic spread of Slavic people.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe9076f1700f14e43c67069b0e161103Test
http://hdl.handle.net/10230/28183Test

المؤلفون: Dragan Primorac, Vedrana Škaro, Petar Projić, Saša Missoni, Ivana Horjan Zanki, Siniša Merkaš, Jelena Šarac, Natalija Novokmet, Andrea Ledić, Adela Makar, Gordan Lauc, Šimun Anđelinović, Željana Bašić, Ivana Kružić, Marijana Neuberg, Martina Smolić, Robert Smolić, Irena Hrstić, Dragan Trivanović, Rijad Konjhodžić, Lana Salihefendić, Naida Babić Jordamović, Damir Marjanović

المصدر: Scopus-Elsevier

مصطلحات موضوعية: Chromosomes, Human, Y, Genetics, Population, Croatia, Genetic Variation, Haplotypes, Humans, Microsatellite Repeats, Phylogeny, General Medicine

الوصف: Aim To analyze an additional set of 'Y-chromosome genetic markers to acquire a more detailed insight into the diversity of the Croatian population. Methods A total of 518 Yfiler Plus profiles were genotyped. Allele frequencies, haplotype frequencies, and haplotype diversity were calculated by using the STRAF software v. 2.0.4. Genetic distances were quantified by Rst with AMOVA online tool from the YHRD. The evolutionary history was inferred with the neighbor-joining method of phylogenetic tree construction in the MEGAX software. Whit Athey's Haplogroup Predictor v. 5 was used for additional comparison with regional and other European populations. Results A total of 507 haplotypes were used for genetic STR analysis. An interpopulation study on 17 Y-STR markers showed the lowest genetic diversity between the Croatian and Bosnian-Herzegovinian populations and the highest between the Croatian and Irish populations. Additional interpopulation comparison with the original 27 Y-STR markers (for the population with available data) was also performed. A total of 518 haplotypes were used in the determination of haplogroup diversity. Haplogroup I with its sublineage I2a expressed the highest prevalence. The second most prevalent haplogroup was R, with its major sublineage R1a, except for the subpopulation of Hvar, where E1b1b was the second most prevalent haplogroup. Rare haplogroups also confirmed in this study were L, T, and Q. G1 was detected for the first time in the Croatian population. Conclusion We obtained a new insight into the differences between examined subpopulations of Croatia and their possible (dis)similarities with neighboring and distant populations.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e75c899592639b43683e1699fa7a7eTest
http://www.scopus.com/inward/record.url?eid=2-s2.0-85132313277&partnerID=MN8TOARSTest