التفاصيل البيبلوغرافية
| العنوان: |
Low dietary magnesium intake alters vitamin D—parathyroid hormone relationship in adults who are overweight or obese. |
| المؤلفون: |
Cheung, May M.1 (AUTHOR) mmc372@drexel.edu, DeLuccia, Rosemary1 (AUTHOR) rkd44@drexel.edu, Ramadoss, Rohit Kumar2 (AUTHOR) rr627@drexel.edu, Aljahdali, Abeer1 (AUTHOR) aaoaljahdali1@kau.edu.sa, Volpe, Stella L.1 (AUTHOR) slv43@drexel.edu, Shewokis, Patricia A.3 (AUTHOR) pas38@drexel.edu, Sukumar, Deeptha1 (AUTHOR) deeptha.sukumar@drexel.edu |
| المصدر: |
Nutrition Research. Sep2019, Vol. 69, p82-93. 12p. |
| مصطلحات موضوعية: |
*VITAMIN D metabolism, *BLOOD collection, *BODY composition, *DIET, *INGESTION, *MAGNESIUM, *OBESITY, *PARATHYROID hormone, *QUESTIONNAIRES, *BODY mass index, *CROSS-sectional method, *DESCRIPTIVE statistics, *PHOTON absorptiometry |
| مستخلص: |
Vitamin D metabolism is dependent on magnesium (Mg) as a cofactor; therefore, poor Mg status may alter the relationship between vitamin D metabolite serum 25-hydroxyvitamin D (s25OHD) and serum parathyroid hormone (sPTH). We hypothesized that low dietary Mg intake may alter sPTH response to s25OHD in a population with excess body weight, thereby leading to a worsening of cardiometabolic health. To explore this hypothesis, we conducted a cross-sectional study on adults who were either overweight or obese (owt/ob). Dietary Mg intake was measured using a Mg food frequency questionnaire (MgFFQ). Body composition information was measured using Dual Energy X-ray Absorptiometry (DXA). Blood samples were obtained for all biochemical analyses. A total of 57 participants, 22 to 65 years of age, with a body mass index between 25 to 45 kg/m2 were divided into 3 groups, according to dietary Mg intake percentiles (Low Mg Group = <33 percentile, Medium Mg Group = 33 to 66 percentile, High Mg Group = >66 percentile). Higher s25OHD was negatively associated with lower sPTH in the High Mg Intake group (r = −0.472, P =.041), but not in other groups. A positive relationship between s25OHD and serum high-molecular weight adiponectin concentrations was observed in the High Mg Group (r = 0.532, r = 0.022), but not in other groups. Serum Interleukin-6 concentrations were negatively associated with s25OHD (r = −0.316, P =.017) for the entire study group. Based on these results, our study demonstrated that a low dietary Mg intake may alter PTH response to 25OHD. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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