التفاصيل البيبلوغرافية
| العنوان: |
Microvascular blood flow dynamics associated with photodynamic therapy, pulsed dye laser irradiation and combined regimens |
| المؤلفون: |
Smith, Tia K, Choi, Bernard, Ramirez‐San‐Juan, Julio C, Nelson, J Stuart, Osann, Kathryn, Kelly, Kristen M |
| المصدر: |
Lasers in Surgery and Medicine, vol 38, iss 5 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2006 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Clinical Sciences, Animals, Female, Low-Level Light Therapy, Microcirculation, Models, Animal, Photochemotherapy, Photosensitizing Agents, Porphyrins, Rats, Sprague-Dawley, Regional Blood Flow, Skin, Verteporfin, photodynamic therapy, pulsed dye laser, benzoporphyrin, laser speckle imaging, Dermatology & Venereal Diseases, Dentistry |
| جغرافية الموضوع: |
532 - 539 |
| الوصف: |
Background and objectivesPrevious in vitro studies demonstrated the potential utility of benzoporphyrin derivative monoacid ring A (BPD) photodynamic therapy (PDT) for vascular destruction. Moreover, the effects of PDT were enhanced when this intervention was followed immediately by pulsed dye laser (PDL) irradiation (PDT/PDL). We further evaluate vascular effects of PDT alone, PDL alone and PDT/PDL in an in vivo rodent dorsal skinfold model.Study design/materials and methodsA dorsal skinfold window chamber was installed surgically on female Sprague-Dawley rats. One milligram per kilogram of BPD solution was administered intravenously via a jugular venous catheter. Evaluated interventions were: control (no BPD, no light), PDT alone (576 nm, 16 minutes exposure time, 15 minutes post-BPD injection, 10 mm spot), PDL alone at 7 J/cm2 (585 nm, 1.5 ms pulse duration, 7 mm spot), PDL alone at 10 J/cm2, PDT/PDL (PDL at 7 J/cm2), and PDT/PDL (PDL at 10 J/cm2). To assess changes in microvascular blood flow, laser speckle imaging was performed before, immediately after, and 18 hours post-intervention.ResultsEpidermal irradiation was accomplished without blistering, scabbing or ulceration. A reduction in perfusion was achieved in all intervention groups. PDT/PDL at 7 J/cm2 resulted in the greatest reduction in vascular perfusion (56%).ConclusionsBPD PDT can achieve safe and selective vascular flow reduction. PDT/PDL can enhance diminution of microvascular blood flow. Our results suggest that PDT and PDT/PDL should be evaluated as alternative therapeutic options for treatment of hypervascular skin lesions including port wine stain birthmarks. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt47v5h6h0; https://escholarship.org/uc/item/47v5h6h0Test |
| الإتاحة: |
https://escholarship.org/uc/item/47v5h6h0Test |
| حقوق: |
CC-BY |
| رقم الانضمام: |
edsbas.AF86EE5F |
| قاعدة البيانات: |
BASE |
