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1
المؤلفون: Lindsay C, Spender, G John, Ferguson, Gareth D, Hughes, Barry R, Davies, Frederick W, Goldberg, Blanca, Herrera, Richard G, Taylor, Lauren S, Strathearn, Owen J, Sansom, Simon T, Barry, Gareth J, Inman
المصدر: Molecular pharmacology. 95(2)
مصطلحات موضوعية: Receptor, Transforming Growth Factor-beta Type I, Smad2 Protein, Cell Line, DNA-Binding Proteins, Mice, Bone Morphogenetic Proteins, NIH 3T3 Cells, Animals, Neoplasm Metastasis, Phosphorylation, Activin Receptors, Type I, Protein Kinase Inhibitors, Cell Proliferation, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::450dfb12551ade5dad0de67c197e09c5Test
https://pubmed.ncbi.nlm.nih.gov/30459156Test -
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المؤلفون: Phillippa Dudley, Neil H. James, Claire Crafter, John Vincent, Barry R. Davies, Teresa Klinowska, Eric Tang
المصدر: International Journal of Oncology
مصطلحات موضوعية: MAPK/ERK pathway, Cancer Research, Receptor, ErbB-2, feedback, Breast Neoplasms, Pharmacology, Biology, Receptor tyrosine kinase, combination therapy, Mice, Trastuzumab, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, medicine, PI3K/AKT/mTOR, Animals, Humans, Pyrroles, HER2-amplified breast cancer, skin and connective tissue diseases, Protein kinase B, PI3K/AKT/mTOR pathway, Cell Proliferation, Cell growth, Gene Amplification, Cancer, Drug Synergism, Articles, medicine.disease, Xenograft Model Antitumor Assays, AZD5363, Pyrimidines, Oncology, Drug Resistance, Neoplasm, MCF-7 Cells, Quinazolines, biology.protein, Phosphorylation, Female, Proto-Oncogene Proteins c-akt, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16a0e9136df3078b9af2fd2524426a6Test
https://doi.org/10.3892/ijo.2015.3062Test -
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المؤلفون: Michael Ittmann, Peter S. Nelson, Paul D. Smith, Barry R. Davies, Shu Feng, Longjiang Shao, Ilsa Coleman, Patricia Castro
المصدر: Oncotarget
مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Male, STAT3 Transcription Factor, medicine.medical_specialty, kinase inhibitor, Mice, SCID, Fibroblast growth factor, Piperazines, 03 medical and health sciences, Internal medicine, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, medicine, Animals, Humans, Pyrroles, Receptor, Fibroblast Growth Factor, Type 1, Phosphorylation, Extracellular Signal-Regulated MAP Kinases, Protein kinase B, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Cell Proliferation, Dose-Response Relationship, Drug, Kinase, business.industry, Fibroblast growth factor receptor 1, AKT, fibroblast growth factors, Prostatic Neoplasms, prostate cancer, Xenograft Model Antitumor Assays, 3. Good health, Tumor Burden, 030104 developmental biology, Endocrinology, Pyrimidines, Oncology, Fibroblast growth factor receptor, Benzamides, Cancer research, Pyrazoles, Signal transduction, business, Proto-Oncogene Proteins c-akt, signal transduction, Research Paper
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a286cbf59b00d90c15d81932e9cb0d4eTest
https://pubmed.ncbi.nlm.nih.gov/28008155Test -
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المؤلفون: Eeva Sommer, Dario R. Alessi, Barry R. Davies, Darren Cross, Sylvie Guichard, Hannah Dry
المصدر: Biochemical Journal. 452:499-508
مصطلحات موضوعية: Molecular Sequence Data, Breast Neoplasms, Signal transduction inhibitor, Protein Serine-Threonine Kinases, Biology, Biochemistry, mTORC2, Immediate early protein, Immediate-Early Proteins, Predictive Value of Tests, Cell Line, Tumor, Animals, Humans, Amino Acid Sequence, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Cell Proliferation, Sheep, Cell growth, Kinase, Cell Biology, Growth Inhibitors, HEK293 Cells, Drug Resistance, Neoplasm, Cancer research, Phosphorylation, Female, Proto-Oncogene Proteins c-akt
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6f9cdd02b445a137e64a9f423bfc8aTest
https://doi.org/10.1042/bj20130342Test -
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المؤلفون: Morris Jeffrey James, Gordon S. Currie, Jason Grant Kettle, Claire Crafter, Clare Lane, Ken Page, Peter Ballard, Linette Ruston, Hannah Dry, Martin Pass, Andrew G. Leach, Ryan Greenwood, Matt Addie, Judit E. Debreczeni, Johnson Paul David, Barry R. Davies, Gillian M. Lamont, Donald J. Ogilvie, David Buttar, Philippa Dudley, Richard W. A. Luke, Stuart E. Pearson
المصدر: Journal of Medicinal Chemistry. 56:2059-2073
مصطلحات موضوعية: Models, Molecular, medicine.drug_class, hERG, Administration, Oral, Carboxamide, Pharmacology, Inhibitory Concentration 50, Structure-Activity Relationship, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Humans, Structure–activity relationship, Pyrroles, Protein Kinase Inhibitors, Protein kinase B, biology, Chemistry, Kinase, Xenograft Model Antitumor Assays, Pyrimidines, Biochemistry, biology.protein, Molecular Medicine, Phosphorylation, Female, Proto-Oncogene Proteins c-akt, Drug metabolism
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e89f0e75ec3075ae6b777ac8b9c2c94Test
https://doi.org/10.1021/jm301762vTest -
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المؤلفون: Sally-Ann Ricketts, Christelle Gendrin, Phillippa Dudley, Barry R. Davies, Juliana Maynard
المصدر: Molecular Imaging and Biology. 15:476-485
مصطلحات موضوعية: Cancer Research, Pathology, medicine.medical_specialty, Time Factors, Mice, Nude, Phases of clinical research, Antineoplastic Agents, Mice, Fluorodeoxyglucose F18, Predictive Value of Tests, Cell Line, Tumor, Biomarkers, Tumor, medicine, Animals, Humans, Pyrroles, Radiology, Nuclear Medicine and imaging, Phosphorylation, Protein Kinase Inhibitors, Protein kinase B, PI3K/AKT/mTOR pathway, Dose-Response Relationship, Drug, medicine.diagnostic_test, Akt inhibitor AZD5363, business.industry, Xenograft Model Antitumor Assays, Tumor Burden, Enzyme Activation, Dose–response relationship, Glucose, Pyrimidines, Treatment Outcome, Oncology, Drug development, Positron emission tomography, Positron-Emission Tomography, Cancer research, Biomarker (medicine), Female, business, Proto-Oncogene Proteins c-akt
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d39c5044cbb3d1886f82bafb10e70d8Test
https://doi.org/10.1007/s11307-013-0613-3Test -
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المؤلفون: Colin P.N. Dinney, Barry R. Davies, David J. McConkey, Giovanni Nitti, Ashish M. Kamat, Rian J. Dickstein
المصدر: Cancer Biology & Therapy. 13:1325-1338
مصطلحات موضوعية: Cancer Research, Class I Phosphatidylinositol 3-Kinases, Apoptosis, Biology, Phosphatidylinositol 3-Kinases, chemistry.chemical_compound, Cell Line, Tumor, Autophagy, Humans, Propidium iodide, Phosphorylation, Protein Kinase Inhibitors, Protein kinase B, PI3K/AKT/mTOR pathway, Cell Proliferation, Sirolimus, Pharmacology, Cell growth, TOR Serine-Threonine Kinases, RPTOR, Urinary Bladder Neoplasms, Oncology, chemistry, Mutation, Cancer cell, Cancer research, Molecular Medicine, Signal transduction, Apoptosis Regulatory Proteins, Proto-Oncogene Proteins c-akt, Signal Transduction, Research Paper
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8b688b9e0129cfacdcee7b88f76f91Test
https://doi.org/10.4161/cbt.21793Test -
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المؤلفون: Robert Shaw, Dawn Baker, Margaret Veldman-Jones, Jonathan R. Dry, Dennis Wang, Claire Rooney, Pei Zhang, Sarah Cross, Michael Dymond, Oona Delpuech, Lorraine Mooney, Barry R. Davies, Joanne Wilson, Paul D. Smith, Elaine Kilgour
المصدر: Molecular cancer therapeutics. 15(11)
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, FGFR Inhibition, EGR1, Antineoplastic Agents, Biology, Piperazines, 03 medical and health sciences, Mice, Cell Line, Tumor, Animals, Cluster Analysis, Humans, Protein kinase B, PI3K/AKT/mTOR pathway, Regulation of gene expression, Gene Expression Profiling, Gene Amplification, Reproducibility of Results, Molecular biology, Receptors, Fibroblast Growth Factor, Gene expression profiling, Disease Models, Animal, 030104 developmental biology, Oncology, Gene Expression Regulation, Benzamides, Cancer research, Phosphorylation, Heterografts, Pyrazoles, Female, Signal transduction, Transcriptome, Biomarkers, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f5322a34a71f41b2d372c212f670f1Test
https://pubmed.ncbi.nlm.nih.gov/27550940Test -
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المؤلفون: Gary Fairley, Clare Lane, Phillippa Dudley, Jason Grant Kettle, Janet Hawkins, Shaun M. Fillery, Helen Plant, Simon J. Brown, Paul Faulder, Claire Crafter, Jennifer H. Pink, Hannah Greenwood, Martin Pass, Sabina Cosulich, Barry R. Davies, Keith M. Johnson, Michael James
المصدر: Journal of Medicinal Chemistry. 55:1261-1273
مصطلحات موضوعية: Models, Molecular, Pyridines, Transplantation, Heterologous, Allosteric regulation, Biological Availability, Mice, Nude, Heterocyclic Compounds, 4 or More Rings, Mice, Structure-Activity Relationship, Allosteric Regulation, In vivo, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Protein kinase B, Gene knockdown, Chemistry, Imidazoles, Rats, Pyridazines, Transplantation, Biochemistry, Cell culture, Pyrazines, Quinazolines, Cancer research, Pyrazoles, Molecular Medicine, Phosphorylation, Drug Screening Assays, Antitumor, Heterocyclic Compounds, 3-Ring, Proto-Oncogene Proteins c-akt, Biomarkers, Neoplasm Transplantation
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4440805d2b64b8e0ab58f4d09a24381fTest
https://doi.org/10.1021/jm201394eTest -
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المؤلفون: Shaun E. Grosskurth, Kate Byth, Suprawee Tepsuporn, Dennis Huszar, Scott A. Ezell, Barry R. Davies, Suping Wang, Teeru Bihani, Zhongwu Lai
المصدر: Oncotarget
مصطلحات موضوعية: 0301 basic medicine, B-cell receptor, P70-S6 Kinase 1, Antineoplastic Agents, Protein Serine-Threonine Kinases, 03 medical and health sciences, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, immune system diseases, hemic and lymphatic diseases, Cell Line, Tumor, Proto-Oncogene Proteins, medicine, Humans, Phosphorylation, Protein kinase B, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Ribosomal Protein S6, business.industry, TOR Serine-Threonine Kinases, AKT, Ibrutinib, Ribosomal Protein S6 Kinases, 70-kDa, S6K1, medicine.disease, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Ribosomal protein s6, DLBCL, Immunology, Cancer research, mTOR, Lymphoma, Large B-Cell, Diffuse, Signal transduction, business, Diffuse large B-cell lymphoma, Proto-Oncogene Proteins c-akt, Signal Transduction, Research Paper
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0728816b3798ddcba8997b8d07dc88a7Test
https://pubmed.ncbi.nlm.nih.gov/26824321Test