كتاب
Nephrotoxicity of gentamicin in humans
| العنوان: | Nephrotoxicity of gentamicin in humans |
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| المؤلفون: | De Broe, Marc E, Paulus, Guy L, Verpooten, G A, Roels, Frank, De Prest, Betty, Van Hoof, François, Tulkens, P, Buyssens, N |
| المساهمون: | FILLASTRE, Jean-Paul |
| المصدر: | Néphrotoxicité Ototoxicité médicamenteuses = Nephrotoxicity, ototoxicity of drugs ; ISBN: 2855982170 ; ISBN: 9782855982175 |
| بيانات النشر: | Editions INSERM |
| سنة النشر: | 1982 |
| المجموعة: | Ghent University Academic Bibliography |
| مصطلحات موضوعية: | Medicine and Health Sciences, Biology and Life Sciences, Aminoglycosides, antibiotics, Gentamycin, kidney failure, phospholipidosis, lysosomes, acid phosphatase, ß-glycerophosphate, Lojda, AS-TR-phosphate, electron microscopy, morphometry, Weibel, phospholipase C, Barka & Anderson, gamma-glutamyltransferase, leucin-aminopeptidase, alkaline phosphatase, brush border, periodic acid Schiff PAS |
| الوصف: | The authors made a complete study of humans receiving amino glycoside antibiotics. Renal histology, electron microscopy and morphometry, and histochemistry and biochemistry of alanine aminopeptidase, glucose-6phosphatase, phosphorylase, acid phosphatase, cathepsin B, N-acetyl-ß-D-glucosaminidase, sphyngolyyelinase and phospholipase-A. In 3 patients with acute renal failure following a prolonged treatment with Gentamycin, the activities are diminished of sphyngomyelinase, acid phospholipases and alanine amino peptidase. 5 patients undergoing nephrectomy for cancer, received Gentamicin iv during 4 days prior to surgery. Gentamycin concentration in the cortex is 169 µg/g (mean). By light microscopy no alteration is visible. However by electron microscopy osmiophilic myeloid bodies are seen in the lysosomes of the proximal tubule; the brush order and mitochondria look normal. Lysosomes are identified by acid phosphatase reaction product (lead precipitate). Morphometry shows a near doubling of the lysosomal volume Vv in the proximal epithelium from 2.3% to 4.17% (mean of 5 treated vs 5 control patients). The activity of renal acid phospolipases is diminished in each patient treated with Gentamycin. but other enzymes not regularly modified. Four patients underwent a renal biopsy 4 hrs after Gentamycin injection; by electron microscopy lamellar structures are seen in some lysosomes. This study confirms in the human the renal modifications seen in animals elicited by Gentamycin. 12 electron micrographs; 4 tables; 2 graphs. |
| نوع الوثيقة: | book part |
| وصف الملف: | image/tiff |
| اللغة: | English French |
| ردمك: | 978-2-85598-217-5 2-85598-217-0 |
| العلاقة: | https://biblio.ugent.be/publication/01HEE47ZT2GAQCZ5ESK1T4RB48Test; http://hdl.handle.net/1854/LU-01HEE47ZT2GAQCZ5ESK1T4RB48Test; https://biblio.ugent.be/publication/01HEE47ZT2GAQCZ5ESK1T4RB48/file/01HGE9GNZQ7GH3YFRB1A06DTM2Test |
| الإتاحة: | https://biblio.ugent.be/publication/01HEE47ZT2GAQCZ5ESK1T4RB48Test http://hdl.handle.net/1854/LU-01HEE47ZT2GAQCZ5ESK1T4RB48Test https://biblio.ugent.be/publication/01HEE47ZT2GAQCZ5ESK1T4RB48/file/01HGE9GNZQ7GH3YFRB1A06DTM2Test |
| حقوق: | No license (in copyright) ; info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.A52C7AA1 |
| قاعدة البيانات: | BASE |
| ردمك: | 9782855982175 2855982170 |
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