دورية أكاديمية
Family History is Associated with Phenotype in Dementia with Lewy Bodies
| العنوان: | Family History is Associated with Phenotype in Dementia with Lewy Bodies |
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| المؤلفون: | Vergouw, L.J.M. (Leonie), Bosman, B. (Brechje), van de Beek, M. (Marleen), Salomé, M. (Mariet), Hoogers, S.E. (Susanne), van Steenoven, I. (Inger), Roks, C.M.A.A. (Gerwin), Bonifati, V. (Vincenzo), Swieten, J.C. (John) van, Lemstra, A.W., De Jong, F.J. (Frank J.) |
| المصدر: | Journal of Alzheimer's Disease vol. 73 no. 1, pp. 269-275 |
| سنة النشر: | 2020 |
| المجموعة: | RePub - Publications from Erasmus University, Rotterdam |
| مصطلحات موضوعية: | Dementia with Lewy bodies, family history, phenotype, survival |
| الوصف: | It is currently unknown whether patients with dementia with Lewy bodies (DLB) with relatives with dementia or Parkinson's disease (familial DLB patients) have a different phenotype than sporadic DLB patients. In this study, we aimed to examine disease onset, rate of cognitive decline, survival, and Alzheimer's disease (AD) biomarkers in patients with familial DLB (n = 154) and sporadic DLB (n = 137), using linear mixed model analysis and Cox regression analysis, among others. Familial patients had a shorter survival (8.0 years) and more often elevated cerebrospinal fluid AD biomarkers (47%) than sporadic patients (9.0 years; p≤0.001; 30%, p = 0.037). Our findings suggest that genetic factors are important in DLB and that the identification of new genetic factors will probably improve the prediction of prognosis. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | http://repub.eur.nl/pub/123841Test; urn:hdl:1765/123841 |
| DOI: | 10.3233/JAD-190825 |
| الإتاحة: | https://doi.org/10.3233/JAD-190825Test http://repub.eur.nl/pub/123841Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.2D66F3A1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3233/JAD-190825 |
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