المؤلفون: Pérez-Jiménez, Mercedes M., Monje-Moreno, José M., Brokate-Llanos, Ana María, Venegas-Calerón, Mónica, Sánchez-García, Alicia, Sansigre, Paula, Valladares, Amador, Esteban-García, Sara, Suárez-Pereira, Irene, Vitorica, Javier, Ríos, José Julián, Artal-Sanz, Marta, Carrión, Ángel M., Muñoz, Manuel J.

المساهمون: Pérez-Jiménez,MM, Monje-Moreno,JM, Brokate-Llanos,AM, Sansigre,P, Valladares,A, Artal-Sanz,M, Muñoz,MJ Centro Andaluz de Biología del Desarrollo (CABD)—Universidad Pablo de Olavide (UPO), Departamento de Biología Molecular e Ingeniería Bioquímica, UPO/ CSIC/JA, Sevilla, Spain. Venegas-Calerón,M, Sánchez-García,A, Ríos,JJ Instituto de la Grasa (CSIC), Campus Universitario Pablo de Olavide (UPO), Sevilla, Spain. Esteban-García,S, Suárez-Pereira,I, Carrión,AM Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide (UPO), Sevilla, Spain. Vitorica,J Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain. Vitorica,J Instituto de Biomedicina de Sevilla (IBiS)-Hospital Universitario Virgen del Rocío/ CSIC/Universidad de Sevilla, Sevilla, Spain. Vitorica,J Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. Suárez-Pereira,I Europsychopharmacology and psychobiology research group, Universidad de Cadiz, CIBERSAM, INiBICA, Cadiz, Spain., This work was supported by the Junta de Andalucía Project P07-CVI-02697, “Fondo Europeo de Desarrollo Regional” (FEDER) and the “Consejería de Economía, Conocimiento, Empresas y Universidad, Junta de Andalucía” Project UPO-1266266 and the European Research Council ERC-2011-StG-281691. We also acknowledge the support from the Centro Andaluz de Biología del Desarrollo (CABD).

مصطلحات موضوعية: Longevity, Alzheimer disease, Fertility, Aging, Mutation, Sensory neurons, Phenotype, Testosterone, Steroids, Sulfatases, Longevidad, Enfermedad de alzheimer, Fertilidad, Envejecimiento, Mutación, Células receptoras sensoriales, Fenotipo, Testosterona, Esteroides, Sulfatasas, Medical Subject Headings::Diseases::Nervous System Diseases::Neurodegenerative Diseases::Tauopathies::Alzheimer Disease, Medical Subject Headings::Organisms::Eukaryota::Animals, Medical Subject Headings::Organisms::Eukaryota::Animals::Invertebrates::Helminths::Nematoda::Secernentea::Rhabditida::Rhabditoidea::Caenorhabditis::Caenorhabditis elegans, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Helminth Proteins::Caenorhabditis elegans Proteins, Medical Subject Headings::Diseases::Animal Diseases::Disease Models, Animal, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epistasis, Genetic

وصف الملف: application/pdf; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet; video/msvideo

العلاقة: https://www.nature.com/articles/s41467-020-20269-yTest; Pérez-Jiménez MM, Monje-Moreno JM, Brokate-Llanos AM, Venegas-Calerón M, Sánchez-García A, Sansigre P, et al. Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases. Nat Commun. 2021 Jan 4;12(1):49; http://hdl.handle.net/10668/4311Test; PMC7782729

الإتاحة: https://doi.org/10.1038/s41467-020-20269-yTest
http://hdl.handle.net/10668/4311Test

المؤلفون: Fernandez-Valenzuela, Juan Jose, Sanchez-Varo, Raquel, Muñoz-Castro, Clara, De Castro, Vanessa, Sanchez-Mejias, Elisabeth, Navarro, Victoria, Jimenez, Sebastian, Nuñez-Diaz, Cristina, Gomez-Arboledas, Angela, Moreno-Gonzalez, Ines, Vizuete, Marisa, Davila, Jose Carlos, Vitorica, Javier, Gutierrez, Antonia

المساهمون: Fernandez-Valenzuela,JJ, Sanchez-Varo,R, De Castro,V, Sanchez-Mejias,E, Nuñez-Diaz,C, Gomez-Arboledas,A, Moreno-Gonzalez,I, Davila,JC, Gutierrez,A Dpto. Biología Celular, Genética y Fisiología, Instituto de Investigación Biomédica de Málaga‑IBIMA, Facultad de Ciencias, Universidad de Málaga, Málaga, Spain. Fernandez-Valenzuela,JJ, Muñoz-Castro,C, Navarro,V, Jimenez,S, Vizuete,M, Vitorica,J, Gutierrez,A Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. Muñoz-Castro,C, Vitorica,J Dpto. Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain. Muñoz-Castro,C, Vitorica,J Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocio/CSIC, Universidad de Sevilla, Sevilla, Spain.

مصطلحات موضوعية: Amyloid, Alzheimer disease, Axonal transport, Brain, Interneurons, Tauopathies, Amiloide, Enfermedad de Alzheimer, Transporte axonal, Encéfalo, Interneuronas, Tauopatías, Animals, Cognition Disorders, Epothilones, Female, Humans, Male, Mice, Transgenic, Microtubules, Neurons, Phenotype, Tubulin Modulators, Disease Models, Animal

العلاقة: https://www.nature.com/articles/s41598-020-71767-4Test; http://hdl.handle.net/10668/3590Test; http://hdl.handle.net/20.500.12105/18114Test; Scientific Reports

الإتاحة: https://doi.org/20.500.12105/18114Test
https://doi.org/10.1038/s41598-020-71767-4Test
http://hdl.handle.net/10668/3590Test
https://hdl.handle.net/20.500.12105/18114Test

المؤلفون: José Ríos, Amador Valladares, Irene Suárez-Pereira, Mónica Venegas-Calerón, José M. Monje-Moreno, Paula Sansigre, Sara Esteban-García, Marta Artal-Sanz, Manuel Muñoz, Javier Vitorica, Angel M. Carrión, Alicia Sánchez-García, Ana María Brokate-Llanos, Mercedes M. Pérez-Jiménez

المساهمون: Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular, Junta de Andalucía, European Coal and Steel Community, European Research Council, [Pérez-Jiménez,MM, Monje-Moreno,JM, Brokate-Llanos,AM, Sansigre,P, Valladares,A, Artal-Sanz,M, Muñoz,MJ] Centro Andaluz de Biología del Desarrollo (CABD)—Universidad Pablo de Olavide (UPO), Departamento de Biología Molecular e Ingeniería Bioquímica, UPO/ CSIC/JA, Sevilla, Spain. [Venegas-Calerón,M, Sánchez-García,A, Ríos,JJ] Instituto de la Grasa (CSIC), Campus Universitario Pablo de Olavide (UPO), Sevilla, Spain. [Esteban-García,S, Suárez-Pereira,I, Carrión,AM] Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide (UPO), Sevilla, Spain. [Vitorica,J] Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain. [Vitorica,J] Instituto de Biomedicina de Sevilla (IBiS)-Hospital Universitario Virgen del Rocío/ CSIC/Universidad de Sevilla, Sevilla, Spain. [Vitorica,J] Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. [Suárez-Pereira,I] Europsychopharmacology and psychobiology research group, Universidad de Cadiz, CIBERSAM, INiBICA, Cadiz, Spain., This work was supported by the Junta de Andalucía Project P07-CVI-02697, 'Fondo Europeo de Desarrollo Regional' (FEDER) and the 'Consejería de Economía, Conocimiento, Empresas y Universidad, Junta de Andalucía' Project UPO-1266266 and the European Research Council ERC-2011-StG-281691. We also acknowledge the support from the Centro Andaluz de Biología del Desarrollo (CABD).

المصدر: idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
idUS. Depósito de Investigación de la Universidad de Sevilla

مصطلحات موضوعية: 0301 basic medicine, Aging, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Helminth Proteins::Caenorhabditis elegans Proteins [Medical Subject Headings], Phenomena and Processes::Genetic Phenomena::Phenotype [Medical Subject Headings], medicine.medical_treatment, Envejecimiento, General Physics and Astronomy, Phenomena and Processes::Physiological Phenomena::Longevity [Medical Subject Headings], Protein aggregation, Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Learning::Cues [Medical Subject Headings], Mice, 0302 clinical medicine, Anatomy::Urogenital System::Genitalia::Gonads [Medical Subject Headings], Organisms::Eukaryota::Animals [Medical Subject Headings], Testosterone, Testosterona, Caenorhabditis elegans, media_common, Multidisciplinary, biology, Sulfatase, Anatomy::Cells::Neurons::Neurons, Afferent::Sensory Receptor Cells [Medical Subject Headings], Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Gonadal Hormones::Gonadal Steroid Hormones::Testosterone Congeners::Testosterone [Medical Subject Headings], Longevity, Phenotype, Cell biology, Esteroides, Steroids, Sulfatases, Fenotipo, Sulfatasas, Sensory neurons, Diseases::Nervous System Diseases::Neurodegenerative Diseases::Tauopathies::Alzheimer Disease [Medical Subject Headings], Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation [Medical Subject Headings], Phenotypic screening, Sensory Receptor Cells, Science, media_common.quotation_subject, Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Fertility [Medical Subject Headings], General Biochemistry, Genetics and Molecular Biology, Article, Steroid, 03 medical and health sciences, Alzheimer Disease, Anatomy::Cells::Germ Cells [Medical Subject Headings], parasitic diseases, Steroid sulfatase, medicine, Animals, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Esterases::Sulfatases::Arylsulfatases::Steryl-Sulfatase [Medical Subject Headings], Caenorhabditis elegans Proteins, Gonads, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice [Medical Subject Headings], Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Esterases::Sulfatases [Medical Subject Headings], Enfermedad de alzheimer, Mutación, Chemicals and Drugs::Polycyclic Compounds::Steroids [Medical Subject Headings], fungi, Epistasis, Genetic, General Chemistry, Organisms::Eukaryota::Animals::Invertebrates::Helminths::Nematoda::Secernentea::Rhabditida::Rhabditoidea::Caenorhabditis::Caenorhabditis elegans [Medical Subject Headings], biology.organism_classification, Diseases::Animal Diseases::Disease Models, Animal [Medical Subject Headings], Ageing, Disease Models, Animal, 030104 developmental biology, Fertility, Fertilidad, Longevidad, Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epistasis, Genetic [Medical Subject Headings], Mutation, Steryl-Sulfatase, Células receptoras sensoriales, 030217 neurology & neurosurgery, Hormone

وصف الملف: application/pdf; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128e349166f272ab02aca1badb82eb4cTest

المؤلفون: Victoria Navarro, Javier Vitorica, Cristina Nuñez-Diaz, Sebastian Jimenez, Elisabeth Sanchez-Mejias, Angela Gomez-Arboledas, Clara Muñoz-Castro, Marisa Vizuete, Raquel Sanchez-Varo, Juan Jose Fernandez-Valenzuela, Ines Moreno-Gonzalez, Jose Carlos Davila, Antonia Gutierrez, Vanessa De Castro

المساهمون: Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular, Instituto de Salud Carlos III (ISCiii) de España, European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER), Centro de Investigación Biomédica en Red (CIBERNED), Instituto de Salud Carlos III, European Commission, Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España), Universidad de Málaga, Ministerio de Ciencia, Innovación y Universidades (España), [Fernandez-Valenzuela,JJ, Sanchez-Varo,R, De Castro,V, Sanchez-Mejias,E, Nuñez-Diaz,C, Gomez-Arboledas,A, Moreno-Gonzalez,I, Davila,JC, Gutierrez,A] Dpto. Biología Celular, Genética y Fisiología, Instituto de Investigación Biomédica de Málaga‑IBIMA, Facultad de Ciencias, Universidad de Málaga, Málaga, Spain. [Fernandez-Valenzuela,JJ, Muñoz-Castro,C, Navarro,V, Jimenez,S, Vizuete,M, Vitorica,J, Gutierrez,A] Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. [Muñoz-Castro,C, Vitorica,J] Dpto. Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain. [Muñoz-Castro,C, Vitorica,J] Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocio/CSIC, Universidad de Sevilla, Sevilla, Spain., This study was supported by Instituto de Salud Carlos III (ISCiii) of Spain, co-financed by FEDER funds from European Union, through grants PI15/00796 and PI18/01557 (both to AG), PI15/00957 and PI18/01556 (both to JV), and CIBERNED (CB06/05/1116 to AG and CB06/05/0094 to JV), by Malaga University grant PPIT.UMA.B1.2017/26 (to RSV). JJFV and CMC were supported by FPU PhD fellowships (Spanish Ministry of Science, Innovation and Universities). RSV held a postdoctoral contract from Malaga University. IMG is recipient of a senior postdoctoral contract from Ramon y Cajal Program (Spain Government).

المصدر: idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
Scientific Reports
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)

مصطلحات موضوعية: Male, Phenomena and Processes::Genetic Phenomena::Phenotype [Medical Subject Headings], Interneuronas, Psychiatry and Psychology::Mental Disorders::Delirium, Dementia, Amnestic, Cognitive Disorders::Cognition Disorders [Medical Subject Headings], lcsh:Medicine, Hippocampal formation, Chemicals and Drugs::Organic Chemicals::Lactones::Macrolides::Epothilones [Medical Subject Headings], Axonal Transport, Microtubules, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Mice, Enfermedad de Alzheimer, Organisms::Eukaryota::Animals [Medical Subject Headings], Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Genetically Modified::Mice, Transgenic [Medical Subject Headings], lcsh:Science, Anatomy::Nervous System::Neurons [Medical Subject Headings], Neurons, Tauopatías, Multidisciplinary, Diseases::Nervous System Diseases::Neurodegenerative Diseases::Tauopathies [Medical Subject Headings], Neurodegeneration, Brain, Tubulin Modulators, Phenotype, Tauopathies, Encéfalo, Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Cytoskeleton::Microtubules [Medical Subject Headings], GABAergic, Female, Intracellular, Amyloid, Diseases::Nervous System Diseases::Neurodegenerative Diseases::Tauopathies::Alzheimer Disease [Medical Subject Headings], Transporte axonal, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Mitosis Modulators::Antimitotic Agents::Tubulin Modulators [Medical Subject Headings], Check Tags::Male [Medical Subject Headings], Mice, Transgenic, Biology, Neuroprotection, Article, Interneurons, Alzheimer Disease, Microtubule, Extracellular, medicine, Animals, Humans, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice [Medical Subject Headings], Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cytoplasmic Streaming::Axonal Transport [Medical Subject Headings], Amiloide, lcsh:R, medicine.disease, Cellular neuroscience, Diseases::Animal Diseases::Disease Models, Animal [Medical Subject Headings], Disease Models, Animal, Check Tags::Female [Medical Subject Headings], Epothilones, Axoplasmic transport, Diseases of the nervous system, lcsh:Q, Cognition Disorders, Neuroscience

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b39d3ef1f5d5b5670302ad56d41ea8ecTest
https://doi.org/10.1038/s41598-020-71767-4Test