دورية أكاديمية
Inter-observer agreement for the histological diagnosis of invasive lobular breast carcinoma
| العنوان: | Inter-observer agreement for the histological diagnosis of invasive lobular breast carcinoma |
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| المؤلفون: | Christgen, M., Kandt, L.D., Antonopoulos, W., Bartels, S., Van Bockstal, M.R., Bredt, M., Brito, M.J., Christgen, H., Colpaert, C., Cserni, B., Cserni, G., Daemmrich, M.E., Danebrock, R., Dedeurwaerdere, F., van Deurzen, C.H.M., Erber, R., Fathke, C., Feist, H., Fiche, M., Gonzalez, C.A., ter Hoeve, N.D., Kooreman, L., Krech, T., Kristiansen, G., Kulka, J., Laenger, F., Lafos, M., Lehmann, U., Martin-Martinez, M.D., Mueller, S., Pelz, E., Raap, M., Ravarino, A., Reineke-Plaass, T., Schaumann, N., Schelfhout, A.M., De Schepper, M., Schlue, J., Van de Vijver, K., Waelput, W., Wellmann, A., Graeser, M., Gluz, O., Kuemmel, S., Nitz, U., Harbeck, N., Desmedt, C., Floris, G., Derksen, P.W.B., van Diest, P.J. |
| المصدر: | Christgen , M , Kandt , L D , Antonopoulos , W , Bartels , S , Van Bockstal , M R , Bredt , M , Brito , M J , Christgen , H , Colpaert , C , Cserni , B , Cserni , G , Daemmrich , M E , Danebrock , R , Dedeurwaerdere , F , van Deurzen , C H M , Erber , R , Fathke , C , Feist , H , Fiche , M , Gonzalez , C A , ter Hoeve , N D , Kooreman , L , .... |
| سنة النشر: | 2022 |
| المجموعة: | Maastricht University Research Publications |
| مصطلحات موضوعية: | lobular breast carcinoma, diagnosis, quality assurance, beta-catenin, p120-catenin, tubular elements, ELBCC/LOBSTERPOT consortium, E-CADHERIN EXPRESSION, TUBULOLOBULAR CARCINOMA, CANCER, REPRODUCIBILITY, MORPHOLOGY, PHENOTYPE, CATENIN, GROWTH |
| الوصف: | Invasive lobular breast carcinoma (ILC) is the second most common breast carcinoma (BC) subtype and is mainly driven by loss of E-cadherin expression. Correct classification of BC as ILC is important for patient treatment. This study assessed the degree of agreement among pathologists for the diagnosis of ILC. Two sets of hormone receptor (HR)-positive/HER2-negative BCs were independently reviewed by participating pathologists. In set A (61 cases), participants were provided with hematoxylin/eosin (HE)-stained sections. In set B (62 cases), participants were provided with HE-stained sections and E-cadherin immunohistochemistry (INC). Tumor characteristics were balanced. Participants classified specimens as non-lobular BC versus mixed BC versus ILC. Pairwise inter-observer agreement and agreement with a pre-defined reference diagnosis were determined with Cohen's kappa statistics. Subtype calls were correlated with molecular features, including CDH1/E-cadherin mutation status. Thirty-five pathologists completed both sets, providing 4,305 subtype calls. Pairwise inter-observer agreement was moderate in set A (median kappa = 0.58, interquartile range [IQR]: 0.48-0.66) and substantial in set B (median kappa = 0.75, IQR: 0.56-0.86, p < 0.001). Agreement with the reference diagnosis was substantial in set A (median kappa = 0.67, IQR: 0.57-0.75) and almost perfect in set B (median kappa = 0.86, IQR: 0.73-0.93, p < 0.001). The median frequency of CDH1/E-cadherin mutations in specimens classified as ILC was 65% in set A (IQR: 56-72%) and 73% in set B (IQR: 65-75%, p < 0.001). Cases with variable subtype calls included E-cadherin-positive ILCs harboring CDH1 missense mutations, and E-cadherin-negative ILCs with tubular elements and focal P-cadherin expression. ILCs with trabecular growth pattern were often misclassified as non-lobular BC in set A but not in set B. In conclusion, subtyping of BC as ILC achieves almost perfect agreement with a pre-defined reference standard, if assessment is supported by E-cadherin ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://cris.maastrichtuniversity.nl/en/publications/4f31f85f-b0ce-42ca-975e-424cb3cb838bTest |
| DOI: | 10.1002/cjp2.253 |
| الإتاحة: | https://doi.org/10.1002/cjp2.253Test https://cris.maastrichtuniversity.nl/en/publications/4f31f85f-b0ce-42ca-975e-424cb3cb838bTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.21FAAE3F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/cjp2.253 |
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