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1دورية أكاديمية
المؤلفون: Taouès Temal-Laib, Christophe Peixoto, Nicolas Desroy, Elsa De Lemos, Florence Bonnaterre, Natacha Bienvenu, Olivier Picolet, Eric Sartori, Denis Bucher, Miriam López-Ramos, Carlos Roca Magadán, Wendy Laenen, Thomas Flower, Patrick Mollat, Olivier Bugaud, Robert Touitou, Anna Pereira Fernandes, Stephanie Lavazais, Alain Monjardet, Monica Borgonovi, Romain Gosmini, Reginald Brys, David Amantini, Steve De Vos, Martin Andrews
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Immunology, Cancer, Inorganic Chemistry, Hematology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, throughput screening campaign, protein kinase amp, activated protein kinase, immunoregulatory cytokine production, clinical candidate glpg3312, pharmacokinetic investigations led, pharmacokinetic properties, immunoregulatory activities, glpg3312 demonstrated, vivo <, vitro <, threonine kinases, therapeutic potential, subsequent hit, sik inhibitor, mouse models, inducible kinases, dual mechanism
الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c01428.s001Test
https://figshare.com/articles/journal_contribution/Optimization_of_Selectivity_and_Pharmacokinetic_Properties_of_Salt_Inducible_Kinase_Inhibitors_that_Led_to_the_Discovery_of_Pan-SIK_Inhibitor_GLPG3312/24904973Test -
2دورية أكاديمية
المؤلفون: Franck Brebion (2439052), Romain Gosmini (1738168), Pierre Deprez (1705699), Marie Varin (2479900), Christophe Peixoto (2035117), Luke Alvey (2035129), Hélène Jary (2035114), Natacha Bienvenu (1705657), Nicolas Triballeau (1400671), Roland Blanque (3989681), Céline Cottereaux (9412031), Thierry Christophe (242276), Nele Vandervoort (3989705), Patrick Mollat (206614), Robert Touitou (4376779), Philip Leonard (1621432), Frédéric De Ceuninck (1417306), Iuliana Botez (1701322), Alain Monjardet (3989687), Ellen van der Aar (3989690), David Amantini (232220)
مصطلحات موضوعية: Biochemistry, Medicine, Cell Biology, Neuroscience, Physiology, Pharmacology, Biotechnology, Cancer, Science Policy, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, phase 2, knee OA, 1.5 μ M, DMOAD, hydantoin series, Biochemical activity, cocrystal structure, anticatabolic activity, IC 50, glycosaminoglycan release, disease-modifying osteoarthritis, mouse cartilage explants, NCT, GLPG, aggrecanase ADAMTS, HTS, fluorescence-based assay, AGC ELISA
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المؤلفون: L. Lepescheux, R. Gosmini, F. De Ceuninck, Thierry Christophe, E. van der Aar, I. Botez, Nele Vandervoort, Pierre Deprez, D. Amantini, Roland Blanque, D. Merciris, Robert Touitou, Philippe Clément-Lacroix, C. Cottereaux, S. Meurisse, Patrick Mollat, F. Brebion, D. Comas, Christopher B. Little, Margaret M. Smith
المصدر: Osteoarthritis and Cartilage. 30:291-301
مصطلحات موضوعية: Metalloproteinase, biology, Chemistry, Cartilage, Biomedical Engineering, Osteoarthritis, Pharmacology, medicine.disease, Piperazines, Rats, Glycosaminoglycan, Mice, medicine.anatomical_structure, Rheumatology, Proteoglycan, In vivo, biology.protein, medicine, Animals, Humans, Orthopedics and Sports Medicine, ADAMTS5 Protein, Aggrecan, Aggrecanase
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3703c4b9781633c63762275b997650Test
https://doi.org/10.1016/j.joca.2021.08.012Test -
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المؤلفون: Alain Monjardet, Thierry Christophe, Nicolas Triballeau, Helene Jary, Luke Jonathan Alvey, Romain Luc Marie Gosmini, Frédéric André De Ceuninck, Pierre Deprez, Robert Touitou, Roland Blanque, D. Amantini, Nele Vandervoort, Ellen van der Aar, Philip Leonard, F. Brebion, Patrick Mollat, Natacha Bienvenu, C. Cottereaux, I. Botez, Varin Marie Laurence Claire, Christophe Peixoto
المصدر: Journal of Medicinal Chemistry. 64:2937-2952
مصطلحات موضوعية: Cartilage, Articular, Models, Molecular, Osteoarthritis, Pharmacology, 01 natural sciences, law.invention, Glycosaminoglycan, Mice, 03 medical and health sciences, Dogs, law, Drug Discovery, medicine, Animals, Humans, IC50, Aggrecan, Glycosaminoglycans, 030304 developmental biology, Aggrecanase, 0303 health sciences, Chemistry, Cartilage, ADAMTS, medicine.disease, Rats, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, Recombinant DNA, Molecular Medicine, ADAMTS5 Protein
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63e1d09bcd2c3ffc719892459e89ab3Test
https://doi.org/10.1021/acs.jmedchem.0c02008Test -
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المؤلفون: R. Gosmini, E. van der Aar, Pierre Deprez, Roland Blanque, Thierry Christophe, L. Lepescheux, Christopher B. Little, Philippe Clément-Lacroix, F. Brebion, C. Cottereaux, D. Amantini, I. Botez, Patrick Mollat, D. Comas, Nele Vandervoort, F. De Ceuninck, S. Meurisse
المصدر: Oral Presentations.
مصطلحات موضوعية: Metalloproteinase, business.industry, ADAMTS, Cartilage, Assay, Osteoarthritis, Matrix metalloproteinase, Pharmacology, medicine.disease, In vitro, medicine.anatomical_structure, In vivo, Medicine, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::9202796e0b4780d3509f8d554349e78cTest
https://doi.org/10.1136/annrheumdis-2017-eular.3775Test -
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المؤلفون: Nele Vandervoort, Xavier Marie Bock, Patrick Mollat, Jovica Ralić, Alain Monjardet, Nicolas Triballeau, Thierry Christophe, Ellen van der Aar, Marieke Lamers, Boska Hrvacic, Nicolas Desroy, Bertrand Heckmann, Line Oste, Emilie Rondet, Virginie Labeguere, Roland Blanque, Veronique Roncoroni, Christopher Gaëtan Housseman, Sandrine Le Tallec, Natacha Bienvenu, C. Cottereaux, M. Auberval, Reginald Brys, Laëtitia Cherel, Emanuelle Wakselman, Picolet Olivier Laurent, Jean-Marie Grassot, Agnès Marie Joncour, Christophe Peixoto, Denis Annoot
مصطلحات موضوعية: 0301 basic medicine, hERG, Pharmacology, autoaxin inhibitor, LPA, pulmonary fibrosis, bleomycin-induced model in mice, 03 medical and health sciences, Idiopathic pulmonary fibrosis, chemistry.chemical_compound, Mice, 0302 clinical medicine, In vivo, Drug Discovery, Pulmonary fibrosis, medicine, Animals, Humans, Thiazole, Mice, Knockout, Lung, medicine.diagnostic_test, biology, Chemistry, Phosphoric Diester Hydrolases, Imidazoles, medicine.disease, Idiopathic Pulmonary Fibrosis, Rats, 030104 developmental biology, Bronchoalveolar lavage, medicine.anatomical_structure, Pyrimidines, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, lipids (amino acids, peptides, and proteins), Autotaxin
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c6f6e80895c7ca93e77aad9243c383Test
https://www.bib.irb.hr/981523Test -
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المؤلفون: John G. Logan, P. Del Soldato, S.H. Ralston, Patrick Mollat, J Frantzias, Anna Sparatore, Aymen I. Idris
المصدر: British Journal of Pharmacology. 165:1914-1925
مصطلحات موضوعية: musculoskeletal diseases, Pharmacology, Osteolysis, Chemistry, Cellular differentiation, Cancer, Osteoblast, IκB kinase, medicine.disease, medicine.anatomical_structure, Osteoclast, Apoptosis, Immunology, Cancer research, medicine, Ex vivo
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::523f7bd2655a9e698a1ef8184f223b7aTest
https://doi.org/10.1111/j.1476-5381.2011.01704.xTest -
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المؤلفون: C. Cottereaux, R. Gosmini, E. van der Aar, D. Amantini, Nele Vandervoort, L. Lepescheux, Patrick Mollat, D. Comas, Pierre Deprez, Roland Blanque, Thierry Christophe, F. Brebion, Christopher B. Little, I. Botez, Philippe Clément-Lacroix, F. De Ceuninck, S. Meurisse
المصدر: Osteoarthritis and Cartilage. 25:S58-S59
مصطلحات موضوعية: 030203 arthritis & rheumatology, 0301 basic medicine, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Rheumatology, business.industry, ADAMTS, Biomedical Engineering, Medicine, Orthopedics and Sports Medicine, Pharmacology, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::2a6ea7e1f012cfa0b4d04832d440fb14Test
https://doi.org/10.1016/j.joca.2017.02.106Test -
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المؤلفون: Francois Nique, Denis Guédin, Nicolas Triballeau, Eric Duval, Jean-Michel Lemoullec, Denis Annoot, Catherine Robin-Jagerschmidt, Maxime Thauvin, Jean-Michel Lefrancois, Thierry Prangé, Laurence Michoux, Philippe Clément-Lacroix, Damien Fleury, Pierre Deprez, Patrick Mollat, Séverine Hebbe, Dominique Minet, Christophe Peixoto
المصدر: Journal of medicinal chemistry. 55(19)
مصطلحات موضوعية: Male, Models, Molecular, Transcriptional Activation, medicine.medical_specialty, Antiandrogens, Hydantoin, Peptide, Pharmacology, Crystallography, X-Ray, Binding, Competitive, Bone and Bones, Transactivation, chemistry.chemical_compound, Structure-Activity Relationship, Anabolic Agents, Internal medicine, Drug Discovery, medicine, Androgen Receptor Antagonists, Potency, Animals, Humans, Muscle, Skeletal, chemistry.chemical_classification, Hydantoins, Prostate, Stereoisomerism, In vitro, Rats, Androgen receptor, Drug Partial Agonism, Endocrinology, Selective androgen receptor modulator, chemistry, Receptors, Androgen, Androgens, Molecular Medicine, Orchiectomy, HeLa Cells
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac608008905445d4f9b1a1f2414f5434Test
https://pubmed.ncbi.nlm.nih.gov/22897611Test