نتائج البحث

41

A photocaged orexin-B for spatiotemporally precise control of orexin signaling

المؤلفون: Duffet, Loic, Tatarskiy, Petr V, Harada, Masaya, Williams, Elyse T, Hartrampf, Nina, Patriarchi, Tommaso

المساهمون: University of Zurich

المصدر: Cell Chemical Biology, 29 (12)

مصطلحات موضوعية: Pharmacology, Orexin-B, Neuropeptides, Photocage, G protein-coupled receptor, Genetically encoded sensors, Biosensor, Clinical Biochemistry, 10050 Institute of Pharmacology and Toxicology, 610 Medicine & health, Biochemistry, Drug Discovery, 570 Life sciences, biology, Molecular Medicine, Molecular Biology

وصف الملف: application/application/pdf; ZORA_pdf.pdf - application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660fde800848fdd970de55ebf84199e8Test
https://pubmed.ncbi.nlm.nih.gov/36481097Test

42

Population Pharmacokinetics and Exposure‐Response Analyses for the Most Frequent Adverse Events Following Treatment With Lemborexant, an Orexin Receptor Antagonist, in Subjects With Insomnia Disorder

المؤلفون: Jagadeesh Aluri, Margaret Moline, Ziad Hussein, Oneeb Majid, Bojan Lalovic, Ishani Landry

المصدر: Journal of Clinical Pharmacology

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Adolescent, exposure‐response analysis, Pyridines, insomnia, Lemborexant, Administration, Oral, Drug Elimination Routes, Placebo, 030226 pharmacology & pharmacy, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Pharmacometrics, Pharmacokinetics, population pharmacokinetics, Sleep Initiation and Maintenance Disorders, Internal medicine, medicine, Humans, Pharmacology (medical), Adverse effect, Aged, Aged, 80 and over, Pharmacology, Clinical Trials as Topic, business.industry, Middle Aged, medicine.disease, Orexin receptor, Pyrimidines, Upper respiratory tract infection, orexin antagonist, Area Under Curve, 030220 oncology & carcinogenesis, Female, Orexin Receptor Antagonists, medicine.symptom, business, Body mass index, Somnolence

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b19a5d8098fca84dc00ffa96a77f0381Test
https://doi.org/10.1002/jcph.1683Test

43

Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793

المؤلفون: Anne E. Fitzgerald, Tatiana Koudriakova, Kevin J. Coe, Anthony Ndifor, Cathy Preville, Christine Dugovic, Neelakandha S. Mani, Nicholas I. Carruthers, Michele C. Rizzolio, Timothy W. Lovenberg, Brock T. Shireman, Diane Nepomuceno, Coate Heather R, Daniel J. Pippel, Brian Lord, Allison Brett Douglas, Curt A. Dvorak, Pascal Bonaventure

المصدر: ACS Med Chem Lett

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b157e2b40c4b8187c17e0918f6f2afcTest
https://doi.org/10.1021/acsmedchemlett.0c00085Test

44

Pharmacological characterization of a novel potent, selective, and orally active orexin 2 receptor antagonist, SDM‐878

المؤلفون: Junji Furukawa, Chika Higashi, Shunsuke Maehara, Takashi Takeuchi, Takumi Ota, Natsuko Yuge

المصدر: Neuropsychopharmacology Reports

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb587ea061a73b9b03f49de9c18959cTest
https://doi.org/10.1002/npr2.12105Test

45

The inhibitory effects of orexin antagonists on the reinforcing properties of amphetamine during brain self-stimulation and the development of a conditioned place preference in rats

المؤلفون: Yulia N. Bessolova, Sergei Vladimirivich Azarenko, Vitalii I. Morozov, Petr Dmitriyevich Shabanov, Andrei A. Lebedev

المصدر: Reviews on Clinical Pharmacology and Drug Therapy. 17:57-64

مصطلحات موضوعية: Lateral hypothalamus, Chemistry, digestive, oral, and skin physiology, Stimulation, General Medicine, Pharmacology, SB-408124, Conditioned place preference, Orexin receptor, Orexin, nervous system, mental disorders, medicine, Adrenergic agonist, Amphetamine, hormones, hormone substitutes, and hormone antagonists, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7e07659fcd177df42ba029969d941414Test
https://doi.org/10.17816/rcf17457-64Test

46

Impact of the Selective Orexin‐1 Receptor Antagonist ACT‐539313 on the Pharmacokinetics of the CYP3A Probe Drug Midazolam in Healthy Male Subjects

المؤلفون: Benjamin Berger, Jasper Dingemanse, Priska Kaufmann, Annelize Koch

المصدر: The Journal of Clinical Pharmacology. 60:931-941

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a45b1401d368d57cd1f5de0f8b1f73Test
https://doi.org/10.1002/jcph.1588Test

47

A simple method using anesthetics to test effects of sleep-inducing substances in mice

المؤلفون: Tomoki Kimura, Hiroto Suzuki, Hirochi Tanji, Yoshinori Iba, Hiroki Murai

المصدر: Journal of Pharmacological Sciences, Vol 142, Iss 2, Pp 79-82 (2020)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bffc657759fba22fd241386728f6695Test
https://doi.org/10.1016/j.jphs.2019.12.003Test

48

Neuropeptide S-initiated sequential cascade mediated by OX1, NK1, mGlu5 and CB1 receptors: a pivotal role in stress-induced analgesia

المؤلفون: Girolamo Calo, Remo Guerrini, Yu-Chun Chiu, Chia Chun Hor, Lih-Chu Chiou, Ming Tatt Lee, Hsin Jung Lee, Yu-Ting Chiu

المصدر: Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-15 (2020)
Journal of Biomedical Science

مصطلحات موضوعية: Male, 0301 basic medicine, Cannabinoid receptor, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, lcsh:Medicine, Substance P, Pharmacology, Mice, chemistry.chemical_compound, 0302 clinical medicine, Receptor, Cannabinoid, CB1, Neuropeptide S, Orexin Receptors, Pharmacology (medical), Chemistry, Glutamate receptor, Neuropeptide S, Orexin, Substance P, Metabotropic glutamate receptor, Endocannabinoid, Periaqueductal gray, General Medicine, CB1, Metabotropic Glutamate 5, Endocannabinoid system, Endocannabinoid, Metabotropic glutamate receptor, Orexin, Periaqueductal gray, Animals, Neuropeptides, Receptor, Metabotropic Glutamate 5, Stress, Psychological, Ventral Thalamic Nuclei, Analgesia, Receptor, Stress, NO, 03 medical and health sciences, mental disorders, Cannabinoid, Molecular Biology, Research, Biochemistry (medical), lcsh:R, Cell Biology, Blockade, 030104 developmental biology, nervous system, Psychological, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2431a8326753b1661e3a5d82baba6b65Test
https://doaj.org/article/53f537b86a584716bdf814fb935a0b18Test

49

OX2receptors mediate the inhibitory effects of orexin‐A on potassium chloride‐induced increases in intracellular calcium ion levels in neurons derived from rat dorsal root ganglion in a chronic pain model

المؤلفون: Tadashi Saigusa, Masami Yamaguchi, Manabu Ishikawa, Yuri Aono

المصدر: Neuropsychopharmacology Reports. 40:30-38

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5eac72e3908bb928f3992efda4eea0b2Test
https://doi.org/10.1002/npr2.12094Test

50

Orexin 2 receptor is involved in orexin A-induced hyperlocomotion in rats

المؤلفون: Shunsuke Maehara, Takumi Ota, Junji Furukawa

المصدر: Pharmacological Reports. 71:1147-1150

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5733e0058e411aba039f6523e0f641Test
https://doi.org/10.1016/j.pharep.2019.06.018Test

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