المؤلفون: Sumiko Yoshikawa, Toshiro Suzuki, Takayuki Shiina, Shintaro Kanda, Toshihiko Agatsuma, Muneharu Hayasaka, Kayoko Ikegami, Takashi Kobayashi, Akemi Matsuo, Tomonobu Koizumi, Shingo Ameshima, Keiichirou Takasuna, Keishi Kubo, Miwa Morikawa

المصدر: CLINICAL LUNG CANCER. 13(6):458-463

مصطلحات موضوعية: Adult, Male, Pulmonary and Respiratory Medicine, Oncology, Cancer Research, medicine.medical_specialty, Lung Neoplasms, Epidermal growth factor receptor tyrosine kinase inhibitor, medicine.medical_treatment, Administration, Oral, Antineoplastic Agents, Pharmacology, Disease-Free Survival, Gefitinib, Carcinoma, Non-Small-Cell Lung, Internal medicine, medicine, Clinical endpoint, Humans, Chemotherapy, Prospective Studies, Recharrenge, Prospective cohort study, Lung cancer, Protein Kinase Inhibitors, Aged, Aged, 80 and over, Salvage Therapy, Response rate (survey), business.industry, Middle Aged, medicine.disease, Gefitinib responder, respiratory tract diseases, Survival Rate, Regimen, Treatment Outcome, Retreatment, Quinazolines, Female, EGFR mutation, business, Non-small-cell lung cancer, Progressive disease, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab46881ed175023602c3fc5ef18bf0fTest
https://soar-ir.repo.nii.ac.jp/records/3738Test

المؤلفون: Tomonobu Koizumi, Toshihiko Agatsuma, Fumiaki Yoshiike, Hiroshi Kuraishi, Kazunari Tateishi, Hiroki Goya, Takashi Ichiyama, Shintaro Kanda, Keishi Kubo, Hiroshi Yamamoto, Shigeru Koyama, Kazuya Hirai

المصدر: Cancer Chemotherapy and Pharmacology. 70:691-697

مصطلحات موضوعية: Adult, Male, Oncology, Cancer Research, medicine.medical_specialty, Lung Neoplasms, Maximum Tolerated Dose, Nausea, medicine.medical_treatment, Neutropenia, Irinotecan, Toxicology, Disease-Free Survival, Carcinoma, Non-Small-Cell Lung, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Pharmacology (medical), Lung cancer, Survival rate, Aged, Tegafur, Salvage Therapy, Pharmacology, Chemotherapy, Dose-Response Relationship, Drug, business.industry, Combination chemotherapy, Middle Aged, medicine.disease, Survival Rate, Drug Combinations, Oxonic Acid, Regimen, Treatment Outcome, Camptothecin, Female, medicine.symptom, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76785c113d7563dc3704276a3c6d184eTest
https://doi.org/10.1007/s00280-012-1957-0Test

المؤلفون: Yoshiaki Kitaguchi, Yunden Droma, Masayuki Hanaoka, Toshihiko Agatsuma, Norbert F. Voelkel, Yan Chen, Keishi Kubo

المصدر: Chest. 139:1101-1108

مصطلحات موضوعية: Male, Pulmonary and Respiratory Medicine, Antioxidant, medicine.medical_treatment, Apoptosis, Inflammation, Matrix metalloproteinase, Pharmacology, Critical Care and Intensive Care Medicine, medicine.disease_cause, Rats, Sprague-Dawley, parasitic diseases, medicine, Animals, Lung, business.industry, Carbocysteine, Smoking, Respiratory disease, respiratory system, medicine.disease, Rats, medicine.anatomical_structure, Pulmonary Emphysema, Carbocisteine, Immunology, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Oxidative stress, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07764468fcce756b5877df83827bcfeTest
https://doi.org/10.1378/chest.10-0920Test

المؤلفون: Keishi Kubo, Tomonobu Koizumi, Sumiko Yoshikawa, Kenji Tsushima

المصدر: EUROPEAN JOURNAL OF PHARMACOLOGY. 641(2-3):220-225

مصطلحات موضوعية: Male, Gabexate, Neutrophils, Sodium, medicine.medical_treatment, Drug Evaluation, Preclinical, Glycine, Proteinase Inhibitory Proteins, Secretory, chemistry.chemical_element, Pharmacology, Lung injury, Rats, Sprague-Dawley, chemistry.chemical_compound, Leukocyte Count, Random Allocation, Neutrophil elastase, medicine, Acute lung injury, Animals, Protease Inhibitors, Saline, Sulfonamides, medicine.diagnostic_test, biology, Acute respiratory distress syndrome, business.industry, Sivelestat, Elastase, Neutrophil, Hydrochloric acid, Drug Synergism, Lung Injury, Rats, Bronchoalveolar lavage, chemistry, Protease inhibitor, Anesthesia, biology.protein, Drug Therapy, Combination, business, Bronchoalveolar Lavage Fluid

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4202d769716164a7c3c95f374207ef07Test
https://soar-ir.repo.nii.ac.jp/records/3871Test

المؤلفون: Atsushi Baba, Keishi Kubo, Tomonobu Koizumi, Ming-Yuan Jian, Toshiki Yokoyama, Kenji Tsushima

المصدر: Pulmonary Pharmacology & Therapeutics. 23:43-47

مصطلحات موضوعية: Male, Pulmonary and Respiratory Medicine, Pentobarbital, medicine.medical_treatment, Acute Lung Injury, Intraperitoneal injection, Anti-Inflammatory Agents, Pharmacology, Lung injury, Pneumonia, Aspiration, Rats, Sprague-Dawley, Pulmonary surfactant, Pulmonary edema, medicine, Animals, Pharmacology (medical), Lung, biology, medicine.diagnostic_test, Chemistry, Bronchoalveolar lavage fluid, Biochemistry (medical), Cytokine-induced neutrophil chemoattractant, Albumin, Pulmonary Surfactants, Rats, Bronchoalveolar lavage, medicine.anatomical_structure, Neutrophil elastase, Anesthesia, biology.protein, Hydrochloric Acid, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0354990146996835d06a282fa65d737cTest
https://doi.org/10.1016/j.pupt.2009.10.004Test

المؤلفون: M. Yasuo, Shuji Toda, Kenji Izuhara, Hiroshi Shiraishi, Hisamichi Aizawa, K. Taniguchi, Keishi Kubo, S. Suzuki, Tomoaki Hoshino, Tadashi Tanabe, Shoichiro Ohta

المصدر: Current Medicinal Chemistry. 16:2867-2875

مصطلحات موضوعية: medicine.medical_treatment, Gene Expression, Mucin 5AC, Biochemistry, Pathogenesis, Th2 Cells, Mediator, Chloride Channels, Drug Discovery, medicine, Animals, Humans, Pharmacology, Interleukin-13, biology, business.industry, Organic Chemistry, Mucin, Pendrin, respiratory system, Hyperplasia, medicine.disease, Mucus, Asthma, Cytokine, Interleukin 13, Immunology, biology.protein, Molecular Medicine, Goblet Cells, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d266b1600244c846db5aa84185cd93c8Test
https://doi.org/10.2174/092986709788803196Test

المؤلفون: Toru Obata, Kenji Tsushima, Tomonobu Koizumi, Keishi Kubo, Sumiko Yoshikawa

المصدر: European Journal of Pharmacology. 535:270-279

مصطلحات موضوعية: Lung Diseases, Male, Time Factors, Neutrophils, Chemokine CXCL1, medicine.medical_treatment, Blood Pressure, Cell Count, Lung injury, Rats, Sprague-Dawley, Leukocyte Count, White blood cell, medicine, Animals, Lung, Polymyxin B, Antibacterial agent, Pharmacology, Chromatography, medicine.diagnostic_test, business.industry, Albumin, Lung Injury, Hemoperfusion, Anti-Bacterial Agents, Rats, Survival Rate, Bronchoalveolar lavage, medicine.anatomical_structure, Immunology, Toxicity, Hydrochloric Acid, business, Bronchoalveolar Lavage Fluid, Chemokines, CXC, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c43397fa6ee0744fddb04e2d741e01eTest
https://doi.org/10.1016/j.ejphar.2006.02.008Test

المؤلفون: Ming-Yuan Jian, Tomonobu Koizumi, Kenji Tsushima, Keisaku Fujimoto, Keishi Kubo

المصدر: Inflammation. 28:327-336

مصطلحات موضوعية: Male, Pathology, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Immunology, Glycine, Lung injury, Pharmacology, Pneumonia, Aspiration, Rats, Sprague-Dawley, Granulocyte Colony-Stimulating Factor, medicine, Animals, Immunology and Allergy, Lung, Saline, Sulfonamides, medicine.diagnostic_test, biology, business.industry, Albumin, Interleukin, Lung Injury, respiratory system, Rats, Granulocyte colony-stimulating factor, Bronchoalveolar lavage, Neutrophil elastase, biology.protein, Tumor necrosis factor alpha, Hydrochloric Acid, Leukocyte Elastase, business, Bronchoalveolar Lavage Fluid

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53efe7c85fc7e9aa9fd5f71a44d9de4aTest
https://doi.org/10.1007/s10753-004-6643-xTest

المؤلفون: Keisaku Fujimoto, Hitoshi Ogasawara, Hiroshi Yamamato, Ming-Yuan Jian, Keishi Kubo, Kenji Tsushima, Tomonobu Koizumi, Zonghai Ruan

المصدر: Anesthesiology. 101:59-65

مصطلحات موضوعية: Pulmonary Circulation, Amidines, Nitric Oxide Synthase Type II, Blood Pressure, Pharmacology, Lung injury, Heterocyclic Compounds, 2-Ring, Nitric oxide, chemistry.chemical_compound, Sepsis, Animals, Medicine, Enzyme Inhibitors, Lung, Sheep, biology, Pulmonary Gas Exchange, business.industry, medicine.disease, Pulmonary edema, Pulmonary hypertension, Endotoxemia, Nitric oxide synthase, Anesthesiology and Pain Medicine, Blood pressure, medicine.anatomical_structure, chemistry, Anesthesia, Acute Disease, biology.protein, Lymph, Blood Gas Analysis, Nitric Oxide Synthase, Respiratory Insufficiency, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::036bf62914e08b63e07c1f11b3681bf8Test
https://doi.org/10.1097/00000542-200407000-00011Test

المؤلفون: Tomonobu Koizumi, Keishi Kubo, Tomohiro Shimo, Yasutaka Kurata, Hideaki Tsuchida, Toshitsugu Ogura, Toshishige Shibamoto, Zonghai Ruan

المصدر: Prostaglandins & Other Lipid Mediators. 73:73-85

مصطلحات موضوعية: Male, medicine.medical_specialty, Physiology, Thromboxane, Guinea Pigs, In Vitro Techniques, Biochemistry, Microcirculation, Constriction, Capillary Permeability, Guinea pig, Thromboxane A2, chemistry.chemical_compound, Internal medicine, medicine, Animals, Bile, Vasoconstrictor Agents, Platelet Activating Factor, Infusion Pumps, Pharmacology, Platelet-activating factor, Portal Vein, Liver Diseases, Organ Size, Cell Biology, medicine.anatomical_structure, Endocrinology, Liver, chemistry, Vasoconstriction, 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid, Reperfusion Injury, Anesthesia, Vascular resistance, Vascular Resistance, medicine.symptom, Liver Circulation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca1dcd4955b5c62f48ec6cc2851a24dTest
https://doi.org/10.1016/j.prostaglandins.2003.11.002Test