المؤلفون: Ilsung Chang, Johanna C. Bendell, Raymond D. Meng, Premal Patel, Sandra M. Sanabria-Bohórquez, Daniel C. Cho, Patricia LoRusso, Matthew Wongchenko, Geoffrey I. Shapiro, Iris T. Chan, Yibing Yan, Luna Musib

المصدر: Investigational New Drugs. 39:163-174

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Oncology, Cobimetinib, medicine.medical_specialty, business.industry, Endometrial cancer, medicine.disease, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Breast cancer, Tolerability, Pharmacokinetics, chemistry, 030220 oncology & carcinogenesis, Internal medicine, Pharmacodynamics, medicine, Pharmacology (medical), business, Ovarian cancer, Adverse effect

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b9452c83b98676f0b80dbf0103f07238Test
https://doi.org/10.1007/s10637-020-00975-6Test

المؤلفون: Buyun Chen, Roland Morley, Kenta Yoshida, Kit Wun Kathy Cheung, Lichuan Liu, Iris T Chan, Sravanthi Cheeti, Srikumar Sahasranaman

المصدر: Drug Metabolism and Disposition. 47:966-973

مصطلحات موضوعية: Adult, Coproporphyrins, Indazoles, Administration, Oral, Pharmaceutical Science, Antineoplastic Agents, Breast Neoplasms, Pharmacology, 030226 pharmacology & pharmacy, Solute Carrier Organic Anion Transporter Family Member 1B3, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, In vivo, Humans, Drug Interactions, Receptor, Aged, Dose-Response Relationship, Drug, biology, Liver-Specific Organic Anion Transporter 1, Chemistry, Transporter, Middle Aged, Drug interaction, Bioavailability, Organic anion-transporting polypeptide, Receptors, Estrogen, Cinnamates, 030220 oncology & carcinogenesis, biology.protein, Feasibility Studies, Biomarker (medicine), Female, Biomarkers, Half-Life

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402261aa975f59481f6e620526e8cc35Test
https://doi.org/10.1124/dmd.119.087924Test

المؤلفون: Lee S. Rosen, Angela Shen, Amy Weise, Jonathan W. Goldman, A. Dimitrios Colevas, Alex A. Adjei, Salim Yazji, Hsin Ju Hsieh, Iris T. Chan, Patricia LoRusso, Branimir I. Sikic, Wen Wee Ma, Stuart Johnston

المصدر: Investigational new drugs, vol 34, iss 5

مصطلحات موضوعية: Male, 0301 basic medicine, MAP Kinase Kinase 2, MAP Kinase Kinase 1, Pharmacology, Gastroenterology, chemistry.chemical_compound, 0302 clinical medicine, Piperidines, Neoplasms, Cobimetinib, 80 and over, Pharmacology (medical), Melanoma, ras, Cancer, Aged, 80 and over, MEK inhibitor, Pharmacology and Pharmaceutical Sciences, Middle Aged, Rash, Treatment Outcome, Oncology, 6.1 Pharmaceuticals, 030220 oncology & carcinogenesis, Vomiting, Female, medicine.symptom, Proto-Oncogene Proteins B-raf, Adult, medicine.medical_specialty, Maximum Tolerated Dose, Class I Phosphatidylinositol 3-Kinases, Nausea, Clinical Trials and Supportive Activities, Antineoplastic Agents, Article, BRAF, Proto-Oncogene Proteins p21(ras), Vaccine Related, 03 medical and health sciences, Phase I, Pharmacokinetics, Clinical Research, Internal medicine, medicine, Humans, Oncology & Carcinogenesis, Adverse effect, Protein Kinase Inhibitors, Aged, business.industry, Evaluation of treatments and therapeutic interventions, Genes, ras, 030104 developmental biology, Genes, chemistry, Pharmacodynamics, Mutation, Azetidines, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361923aa9fba431e1a3e3e602c6cb5c0Test
https://doi.org/10.1007/s10637-016-0374-3Test

المؤلفون: Sravanthi Cheeti, Iris T. Chan, Lichuan Liu, Kenta Yoshida, Buyun Chen, Kit Wun Kathy Cheung, Srikumar Sahasranaman, Roland Morley

المصدر: Drug Metabolism and Pharmacokinetics. 35:S91

مصطلحات موضوعية: Pharmacology, business.industry, Locally advanced, Pharmaceutical Science, Estrogen receptor, First in human, medicine.disease, Breast cancer, Pharmacokinetics, Cancer research, Medicine, Pharmacology (medical), business, Coproporphyrin I

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5fce3141e96f44222d211d458558a515Test
https://doi.org/10.1016/j.dmpk.2020.04.228Test

المؤلفون: Rene Gonzalez, Adil Daud, Ming Yin, Omid Hamid, Peter D. Boasberg, Karl D. Lewis, Anna C. Pavlick, Luna Musib, Igor Puzanov, Grant A. McArthur, Theodore F. Logan, Damien Kee, Thomas F. Gajewski, Antoni Ribas, Lawrence E. Flaherty, Iris T. Chan, Bartosz Chmielowski, Nicholas Choong

المصدر: The Lancet Oncology. 15:954-965

مصطلحات موضوعية: Male, Indoles, Skin Neoplasms, Pharmacology, Gastroenterology, chemistry.chemical_compound, Piperidines, Medicine, Prospective Studies, Infusions, Intravenous, Vemurafenib, Melanoma, Sulfonamides, MEK inhibitor, Middle Aged, Rash, Survival Rate, Treatment Outcome, Oncology, Drug Therapy, Combination, Female, medicine.symptom, medicine.drug, Adult, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Maximum Tolerated Dose, Risk Assessment, Disease-Free Survival, Drug Administration Schedule, Internal medicine, Humans, Neoplasm Invasiveness, Adverse effect, Protein Kinase Inhibitors, Survival rate, Aged, Neoplasm Staging, Cobimetinib, Dose-Response Relationship, Drug, business.industry, Patient Selection, Dabrafenib, medicine.disease, chemistry, Mutation, Azetidines, business, Follow-Up Studies

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f37e6205efc353876207a88d307180Test
https://doi.org/10.1016/s1470-2045Test(14)70301-8

المؤلفون: Mark J. Dresser, Iris T. Chan, Edna F. Choo, Isabelle Rooney, Luna Musib, Yuzhong Deng, Steve Eppler

المصدر: Molecular Pharmaceutics. 10:4046-4054

مصطلحات موضوعية: Adult, Male, Drug, Absorption (pharmacology), medicine.drug_class, media_common.quotation_subject, Cmax, Rabeprazole, Administration, Oral, Biological Availability, Pharmaceutical Science, Proton-pump inhibitor, Pharmacology, Absorption, Young Adult, chemistry.chemical_compound, Piperidines, Drug Discovery, medicine, Humans, media_common, Cobimetinib, Molecular Structure, Chemistry, Proton Pump Inhibitors, Hydrogen-Ion Concentration, Middle Aged, Drug interaction, Bioavailability, Food, Azetidines, Molecular Medicine, Female, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52f3843b73b39bdd612661047c8a741Test
https://doi.org/10.1021/mp400383xTest

المؤلفون: Elizabeth Blackwood, Patricia LoRusso, Joseph A. Ware, S. Gail Eckhardt, Wayne J. Fairbrother, Iris T. Chan, Rebecca Erickson, Stephen E. Gould, Andrew J. Wagner, John A. Flygare, Ron Yu, Ronald Steigerwalt, Kristina West, Walter C. Darbonne, Harvey Wong, Cornelis E. A. C. Hop, Michael Mamounas, Nageshwar Budha

المصدر: Toxicological Sciences. 130:205-213

مصطلحات موضوعية: Male, medicine.medical_specialty, Apoptosis Inhibitor, medicine.medical_treatment, Population, Drug Evaluation, Preclinical, Context (language use), Biology, Pharmacology, Toxicology, Inhibitor of apoptosis, Models, Biological, Inhibitor of Apoptosis Proteins, Rats, Sprague-Dawley, Dogs, Species Specificity, Cyclohexanes, Internal medicine, medicine, Animals, Humans, Pyrroles, education, education.field_of_study, Caspase Inhibitors, Rats, XIAP, Cytokine, Endocrinology, Apoptosis, Area Under Curve, Injections, Intravenous, Cytokines, Female, Tumor necrosis factor alpha, Half-Life

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a21d76a5ce1a57ccfb2adfbd4f06d84Test
https://doi.org/10.1093/toxsci/kfs235Test

المؤلفون: Andrew J. Wagner, Ron Yu, Sarah G. Hymowitz, S. Gail Eckhardt, Joanne Um, Shin G. Young, Bainian Feng, Maureen Beresini, Iris T. Chan, John A. Flygare, Domagoj Vucic, Jason Halladay, Jeffrey Tom, Linda O. Elliott, Karl Doerner, Sravanthi Cheeti, Heidi J.A. Wallweber, Lan Wang, Emile Plise, Lesley J. Murray, Vickie Tsui, Clifford Quan, Eugene Varfolomeev, Melisa L. Wong, Hank La, Frederick Cohen, Patricia LoRusso, Nageshwar Budha, Jonathan M. Wong, Jean Philippe Stephan, Kerry Zobel, Helen Chan, Joseph A. Ware, Lewis J. Gazzard, Matthew C. Franklin, Brigitte Maurer, Kurt Deshayes, Harvey Wong, Zhaoyang Wen, Wayne J. Fairbrother, Stacy Frankovitz Reisner, Susan Wong

المصدر: Journal of medicinal chemistry. 55(9)

مصطلحات موضوعية: Male, Apoptosis Inhibitor, Cell Survival, Ubiquitin-Protein Ligases, Antineoplastic Agents, Apoptosis, Breast Neoplasms, Pharmacology, Inhibitor of apoptosis, Binding, Competitive, Article, Inhibitor of Apoptosis Proteins, Pharmacokinetics, Cell Line, Tumor, Drug Discovery, Thiadiazoles, medicine, Baculoviral IAP Repeat-Containing 3 Protein, Animals, Humans, Clinical Trials, Phase I as Topic, Chemistry, Antagonist, Cancer, medicine.disease, XIAP, Caspases, Molecular Medicine, Female

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9208ca80147ccd15bd753ab49f8a997aTest
https://pubmed.ncbi.nlm.nih.gov/22413863Test

المؤلفون: Johanna C. Bendell, Luna Musib, Shuchi Sumant Pandya, Meghan McKenzie, Cheryl Jones, Alex de Crespigny, Marcia Belvin, Patricia LoRusso, Geoffrey I. Shapiro, Iris T. Chan, Eunice L. Kwak, Mary Gates

المصدر: Journal of Clinical Oncology. 30:2566-2566

مصطلحات موضوعية: Cancer Research, Oncology, business.industry, Medicine, In patient, First in human, Signal transduction, Pharmacology, business, MEK Inhibitor GDC-0973, Protein kinase B, PI3K/AKT/mTOR pathway

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d34456ff568cc524529c4f8970bb5115Test
https://doi.org/10.1200/jco.2012.30.15_suppl.2566Test

المؤلفون: A. de Crespigny, James M. Cleary, Mary Gates, Marcia Belvin, Geoffrey I. Shapiro, Iris T. Chan, Luna Musib, Cheryl Jones, E. L. Kwak, Meghan McKenzie, Johanna C. Bendell, Patricia LoRusso

المصدر: Journal of Clinical Oncology. 29:3005-3005

مصطلحات موضوعية: Cancer Research, Schedule, business.industry, Pharmacology, Intermittent dosing, Oncology, Pharmacokinetics, Medicine, In patient, Dosing, business, Protein kinase B, MEK Inhibitor GDC-0973, PI3K/AKT/mTOR pathway

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::f7d05f21ea1fd761d89ee341cfa4a7f1Test
https://doi.org/10.1200/jco.2011.29.15_suppl.3005Test